Closed-loop deep brain stimulation by pulsatile delayed feedback with increased gap between pulse phases

Abstract Computationally it was shown that desynchronizing delayed feedback stimulation methods are effective closed-loop techniques for the control of synchronization in ensembles of interacting oscillators. We here computationally design stimulation signals for electrical stimulation of neuronal t...

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Autores principales:	Oleksandr V. Popovych, Borys Lysyansky, Peter A. Tass
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/df61adda137a4400918464255cb0cbd3
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spelling	oai:doaj.org-article:df61adda137a4400918464255cb0cbd32021-12-02T16:07:59ZClosed-loop deep brain stimulation by pulsatile delayed feedback with increased gap between pulse phases10.1038/s41598-017-01067-x2045-2322https://doaj.org/article/df61adda137a4400918464255cb0cbd32017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01067-xhttps://doaj.org/toc/2045-2322Abstract Computationally it was shown that desynchronizing delayed feedback stimulation methods are effective closed-loop techniques for the control of synchronization in ensembles of interacting oscillators. We here computationally design stimulation signals for electrical stimulation of neuronal tissue that preserve the desynchronizing delayed feedback characteristics and comply with mandatory charge deposit-related safety requirements. For this, the amplitude of the high-frequency (HF) train of biphasic charge-balanced pulses used by the standard HF deep brain stimulation (DBS) is modulated by the smooth feedback signals. In this way we combine the desynchronizing delayed feedback approach with the HF DBS technique. We show that such a pulsatile delayed feedback stimulation can effectively and robustly desynchronize a network of model neurons comprising subthalamic nucleus and globus pallidus external and suggest this approach for desynchronizing closed-loop DBS. Intriguingly, an interphase gap introduced between the recharging phases of the charge-balanced biphasic pulses can significantly improve the stimulation-induced desynchronization and reduce the amount of the administered stimulation. In view of the recent experimental and clinical studies indicating a superiority of the closed-loop DBS to open-loop HF DBS, our results may contribute to a further development of effective stimulation methods for the treatment of neurological disorders characterized by abnormal neuronal synchronization.Oleksandr V. PopovychBorys LysyanskyPeter A. TassNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Oleksandr V. Popovych Borys Lysyansky Peter A. Tass Closed-loop deep brain stimulation by pulsatile delayed feedback with increased gap between pulse phases
description	Abstract Computationally it was shown that desynchronizing delayed feedback stimulation methods are effective closed-loop techniques for the control of synchronization in ensembles of interacting oscillators. We here computationally design stimulation signals for electrical stimulation of neuronal tissue that preserve the desynchronizing delayed feedback characteristics and comply with mandatory charge deposit-related safety requirements. For this, the amplitude of the high-frequency (HF) train of biphasic charge-balanced pulses used by the standard HF deep brain stimulation (DBS) is modulated by the smooth feedback signals. In this way we combine the desynchronizing delayed feedback approach with the HF DBS technique. We show that such a pulsatile delayed feedback stimulation can effectively and robustly desynchronize a network of model neurons comprising subthalamic nucleus and globus pallidus external and suggest this approach for desynchronizing closed-loop DBS. Intriguingly, an interphase gap introduced between the recharging phases of the charge-balanced biphasic pulses can significantly improve the stimulation-induced desynchronization and reduce the amount of the administered stimulation. In view of the recent experimental and clinical studies indicating a superiority of the closed-loop DBS to open-loop HF DBS, our results may contribute to a further development of effective stimulation methods for the treatment of neurological disorders characterized by abnormal neuronal synchronization.
format	article
author	Oleksandr V. Popovych Borys Lysyansky Peter A. Tass
author_facet	Oleksandr V. Popovych Borys Lysyansky Peter A. Tass
author_sort	Oleksandr V. Popovych
title	Closed-loop deep brain stimulation by pulsatile delayed feedback with increased gap between pulse phases
title_short	Closed-loop deep brain stimulation by pulsatile delayed feedback with increased gap between pulse phases
title_full	Closed-loop deep brain stimulation by pulsatile delayed feedback with increased gap between pulse phases
title_fullStr	Closed-loop deep brain stimulation by pulsatile delayed feedback with increased gap between pulse phases
title_full_unstemmed	Closed-loop deep brain stimulation by pulsatile delayed feedback with increased gap between pulse phases
title_sort	closed-loop deep brain stimulation by pulsatile delayed feedback with increased gap between pulse phases
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/df61adda137a4400918464255cb0cbd3
work_keys_str_mv	AT oleksandrvpopovych closedloopdeepbrainstimulationbypulsatiledelayedfeedbackwithincreasedgapbetweenpulsephases AT boryslysyansky closedloopdeepbrainstimulationbypulsatiledelayedfeedbackwithincreasedgapbetweenpulsephases AT peteratass closedloopdeepbrainstimulationbypulsatiledelayedfeedbackwithincreasedgapbetweenpulsephases
_version_	1718384688292167680

Closed-loop deep brain stimulation by pulsatile delayed feedback with increased gap between pulse phases

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