Maternal high-fat diet during pregnancy with concurrent phthalate exposure leads to abnormal placentation

Abstract Di(2-ethylhexyl) phthalate (DEHP) is a synthetic chemical commonly used for its plasticizing capabilities. Because of the extensive production and use of DEHP, humans are exposed to this chemical daily. Diet is a significant exposure pathway and fatty food contain the highest level of phtha...

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Autores principales:	Athilakshmi Kannan, Juanmahel Davila, Liying Gao, Saniya Rattan, Jodi A. Flaws, Milan K. Bagchi, Indrani C. Bagchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/df61d3b7e2b943d081855f38e81406b4
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spelling	oai:doaj.org-article:df61d3b7e2b943d081855f38e81406b42021-12-02T18:51:41ZMaternal high-fat diet during pregnancy with concurrent phthalate exposure leads to abnormal placentation10.1038/s41598-021-95898-42045-2322https://doaj.org/article/df61d3b7e2b943d081855f38e81406b42021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95898-4https://doaj.org/toc/2045-2322Abstract Di(2-ethylhexyl) phthalate (DEHP) is a synthetic chemical commonly used for its plasticizing capabilities. Because of the extensive production and use of DEHP, humans are exposed to this chemical daily. Diet is a significant exposure pathway and fatty food contain the highest level of phthalates. The impact on pregnancy following DEHP exposure and the associated interaction of high fat (HF) diet remains unknown. Here we report that exposure of pregnant mice to an environmentally relevant level of DEHP did not affect pregnancy. In contrast, mice fed a HF diet during gestation and exposed to the same level of DEHP display marked impairment in placental development, resulting in poor pregnancy outcomes. Our study further reveals that DEHP exposure combined with a HF diet interfere with the signaling pathway controlled by nuclear receptor PPARγ to adversely affect differentiation of trophoblast cells, leading to compromised vascularization and glucose transport in the placenta. Collectively, these findings demonstrate that maternal diet during pregnancy is a critical factor that determines whether exposure to an environmental toxicant results in impaired placental and fetal development, causing intrauterine growth restriction, fetal morbidity, and mortality.Athilakshmi KannanJuanmahel DavilaLiying GaoSaniya RattanJodi A. FlawsMilan K. BagchiIndrani C. BagchiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Athilakshmi Kannan Juanmahel Davila Liying Gao Saniya Rattan Jodi A. Flaws Milan K. Bagchi Indrani C. Bagchi Maternal high-fat diet during pregnancy with concurrent phthalate exposure leads to abnormal placentation
description	Abstract Di(2-ethylhexyl) phthalate (DEHP) is a synthetic chemical commonly used for its plasticizing capabilities. Because of the extensive production and use of DEHP, humans are exposed to this chemical daily. Diet is a significant exposure pathway and fatty food contain the highest level of phthalates. The impact on pregnancy following DEHP exposure and the associated interaction of high fat (HF) diet remains unknown. Here we report that exposure of pregnant mice to an environmentally relevant level of DEHP did not affect pregnancy. In contrast, mice fed a HF diet during gestation and exposed to the same level of DEHP display marked impairment in placental development, resulting in poor pregnancy outcomes. Our study further reveals that DEHP exposure combined with a HF diet interfere with the signaling pathway controlled by nuclear receptor PPARγ to adversely affect differentiation of trophoblast cells, leading to compromised vascularization and glucose transport in the placenta. Collectively, these findings demonstrate that maternal diet during pregnancy is a critical factor that determines whether exposure to an environmental toxicant results in impaired placental and fetal development, causing intrauterine growth restriction, fetal morbidity, and mortality.
format	article
author	Athilakshmi Kannan Juanmahel Davila Liying Gao Saniya Rattan Jodi A. Flaws Milan K. Bagchi Indrani C. Bagchi
author_facet	Athilakshmi Kannan Juanmahel Davila Liying Gao Saniya Rattan Jodi A. Flaws Milan K. Bagchi Indrani C. Bagchi
author_sort	Athilakshmi Kannan
title	Maternal high-fat diet during pregnancy with concurrent phthalate exposure leads to abnormal placentation
title_short	Maternal high-fat diet during pregnancy with concurrent phthalate exposure leads to abnormal placentation
title_full	Maternal high-fat diet during pregnancy with concurrent phthalate exposure leads to abnormal placentation
title_fullStr	Maternal high-fat diet during pregnancy with concurrent phthalate exposure leads to abnormal placentation
title_full_unstemmed	Maternal high-fat diet during pregnancy with concurrent phthalate exposure leads to abnormal placentation
title_sort	maternal high-fat diet during pregnancy with concurrent phthalate exposure leads to abnormal placentation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/df61d3b7e2b943d081855f38e81406b4
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Maternal high-fat diet during pregnancy with concurrent phthalate exposure leads to abnormal placentation

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