Association of HLA alleles with autism

Arezou Sayad,1 Mohammad Taghi Akbari,2 Rezvan Noroozi,3 Mir Davood Omrani,1,4 Hidetoshi Inoko,5 Mohammad Taheri,6 Soudeh Ghafouri-Fard1 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Medical Genetics, Faculty of Medical Sciences, Tarbia...

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Autores principales:	Sayad A, Akbari MT, Noroozi R, Omrani MD, Inoko H, Taheri M, Ghafouri-Fard S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	autism HLA typing immune response Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/df6862e4c93b4f718863d78bb82791ff
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spelling	oai:doaj.org-article:df6862e4c93b4f718863d78bb82791ff2021-12-02T02:52:26ZAssociation of HLA alleles with autism1178-2021https://doaj.org/article/df6862e4c93b4f718863d78bb82791ff2018-11-01T00:00:00Zhttps://www.dovepress.com/association-of-hla-alleles-with-autism-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Arezou Sayad,1 Mohammad Taghi Akbari,2 Rezvan Noroozi,3 Mir Davood Omrani,1,4 Hidetoshi Inoko,5 Mohammad Taheri,6 Soudeh Ghafouri-Fard1 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran; 3Photochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 4Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 5Department of Molecular Life Science, Tokai University, Hiratsuka, Japan; 6Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran Background: Autism spectrum disorders (ASD) are a group of heterogeneous neurodevelopmental disorders known by impaired social interaction and activities and abnormal repetitive behavior. As a multifactorial disorder, several genetic and immunological factors have been shown to be implicated in its pathogenesis. Methods: Among them are certain human leukocyte antigen (HLA) alleles. In the current study, we genotyped HLA-A, -B & DRB alleles in 103 Iranian ASD patients and 180 age, gender, and ethnic-matched healthy controls. Results: After Boferroni correction no allele or haplotype was associated with genetic susceptibility to ASD in Iranian population. Conclusion: Future studies are needed to assess contribution of immunological factors such as HLA alleles in ASD pathogenesis. Keywords: autism, HLA typing, immune responseSayad AAkbari MTNoroozi ROmrani MDInoko HTaheri MGhafouri-Fard SDove Medical PressarticleautismHLA typingimmune responseNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 3259-3265 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	autism HLA typing immune response Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	autism HLA typing immune response Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Sayad A Akbari MT Noroozi R Omrani MD Inoko H Taheri M Ghafouri-Fard S Association of HLA alleles with autism
description	Arezou Sayad,1 Mohammad Taghi Akbari,2 Rezvan Noroozi,3 Mir Davood Omrani,1,4 Hidetoshi Inoko,5 Mohammad Taheri,6 Soudeh Ghafouri-Fard1 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran; 3Photochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 4Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 5Department of Molecular Life Science, Tokai University, Hiratsuka, Japan; 6Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran Background: Autism spectrum disorders (ASD) are a group of heterogeneous neurodevelopmental disorders known by impaired social interaction and activities and abnormal repetitive behavior. As a multifactorial disorder, several genetic and immunological factors have been shown to be implicated in its pathogenesis. Methods: Among them are certain human leukocyte antigen (HLA) alleles. In the current study, we genotyped HLA-A, -B & DRB alleles in 103 Iranian ASD patients and 180 age, gender, and ethnic-matched healthy controls. Results: After Boferroni correction no allele or haplotype was associated with genetic susceptibility to ASD in Iranian population. Conclusion: Future studies are needed to assess contribution of immunological factors such as HLA alleles in ASD pathogenesis. Keywords: autism, HLA typing, immune response
format	article
author	Sayad A Akbari MT Noroozi R Omrani MD Inoko H Taheri M Ghafouri-Fard S
author_facet	Sayad A Akbari MT Noroozi R Omrani MD Inoko H Taheri M Ghafouri-Fard S
author_sort	Sayad A
title	Association of HLA alleles with autism
title_short	Association of HLA alleles with autism
title_full	Association of HLA alleles with autism
title_fullStr	Association of HLA alleles with autism
title_full_unstemmed	Association of HLA alleles with autism
title_sort	association of hla alleles with autism
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/df6862e4c93b4f718863d78bb82791ff
work_keys_str_mv	AT sayada associationofhlaalleleswithautism AT akbarimt associationofhlaalleleswithautism AT noroozir associationofhlaalleleswithautism AT omranimd associationofhlaalleleswithautism AT inokoh associationofhlaalleleswithautism AT taherim associationofhlaalleleswithautism AT ghafourifards associationofhlaalleleswithautism
_version_	1718402132040744960

Association of HLA alleles with autism

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