Effect of Automated Oxygen Titration during Walking on Dyspnea and Endurance in Chronic Hypoxemic Patients with COPD: A Randomized Crossover Trial

The need for oxygen increases with activity in patients with COPD and on long-term oxygen treatment (LTOT), leading to periods of hypoxemia, which may influence the patient’s performance. This study aimed to evaluate the effect of automated oxygen titration compared to usual fixed-dose oxygen treatm...

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Autores principales:	Linette Marie Kofod, Elisabeth Westerdahl, Morten Tange Kristensen, Barbara Cristina Brocki, Thomas Ringbæk, Ejvind Frausing Hansen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	physiotherapy O2matic respiratory failure exercise long-term oxygen treatment Medicine R
Acceso en línea:	https://doaj.org/article/df6b2f3ff46348db8522a359aff91fcd
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spelling	oai:doaj.org-article:df6b2f3ff46348db8522a359aff91fcd2021-11-11T17:29:32ZEffect of Automated Oxygen Titration during Walking on Dyspnea and Endurance in Chronic Hypoxemic Patients with COPD: A Randomized Crossover Trial10.3390/jcm102148202077-0383https://doaj.org/article/df6b2f3ff46348db8522a359aff91fcd2021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4820https://doaj.org/toc/2077-0383The need for oxygen increases with activity in patients with COPD and on long-term oxygen treatment (LTOT), leading to periods of hypoxemia, which may influence the patient’s performance. This study aimed to evaluate the effect of automated oxygen titration compared to usual fixed-dose oxygen treatment during walking on dyspnea and endurance in patients with COPD and on LTOT. In a double-blinded randomised crossover trial, 33 patients were assigned to use either automated oxygen titration or the usual fixed-dose in a random order in two walking tests. A closed-loop device, O2matic delivered a variable oxygen dose set with a target saturation of 90–94%. The patients had a home oxygen flow of (mean ± SD) 1.6 ± 0.9 L/min. At the last corresponding isotime in the endurance shuttle walk test, the patients reported dyspnea equal to median (IQR) 4 (3–6) when using automated oxygen titration and 8 (5–9) when using fixed doses, <i>p</i> < 0.001. The patients walked 10.9 (6.5–14.9) min with automated oxygen compared to 5.5 (3.3–7.9) min with fixed-dose, <i>p</i> < 0.001. Walking with automated oxygen titration had a statistically significant and clinically important effect on dyspnea. Furthermore, the patients walked for a 98% longer time when hypoxemia was reduced with a more well-matched, personalised oxygen treatment.Linette Marie KofodElisabeth WesterdahlMorten Tange KristensenBarbara Cristina BrockiThomas RingbækEjvind Frausing HansenMDPI AGarticlephysiotherapyO2maticrespiratory failureexerciselong-term oxygen treatmentMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4820, p 4820 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	physiotherapy O2matic respiratory failure exercise long-term oxygen treatment Medicine R
spellingShingle	physiotherapy O2matic respiratory failure exercise long-term oxygen treatment Medicine R Linette Marie Kofod Elisabeth Westerdahl Morten Tange Kristensen Barbara Cristina Brocki Thomas Ringbæk Ejvind Frausing Hansen Effect of Automated Oxygen Titration during Walking on Dyspnea and Endurance in Chronic Hypoxemic Patients with COPD: A Randomized Crossover Trial
description	The need for oxygen increases with activity in patients with COPD and on long-term oxygen treatment (LTOT), leading to periods of hypoxemia, which may influence the patient’s performance. This study aimed to evaluate the effect of automated oxygen titration compared to usual fixed-dose oxygen treatment during walking on dyspnea and endurance in patients with COPD and on LTOT. In a double-blinded randomised crossover trial, 33 patients were assigned to use either automated oxygen titration or the usual fixed-dose in a random order in two walking tests. A closed-loop device, O2matic delivered a variable oxygen dose set with a target saturation of 90–94%. The patients had a home oxygen flow of (mean ± SD) 1.6 ± 0.9 L/min. At the last corresponding isotime in the endurance shuttle walk test, the patients reported dyspnea equal to median (IQR) 4 (3–6) when using automated oxygen titration and 8 (5–9) when using fixed doses, <i>p</i> < 0.001. The patients walked 10.9 (6.5–14.9) min with automated oxygen compared to 5.5 (3.3–7.9) min with fixed-dose, <i>p</i> < 0.001. Walking with automated oxygen titration had a statistically significant and clinically important effect on dyspnea. Furthermore, the patients walked for a 98% longer time when hypoxemia was reduced with a more well-matched, personalised oxygen treatment.
format	article
author	Linette Marie Kofod Elisabeth Westerdahl Morten Tange Kristensen Barbara Cristina Brocki Thomas Ringbæk Ejvind Frausing Hansen
author_facet	Linette Marie Kofod Elisabeth Westerdahl Morten Tange Kristensen Barbara Cristina Brocki Thomas Ringbæk Ejvind Frausing Hansen
author_sort	Linette Marie Kofod
title	Effect of Automated Oxygen Titration during Walking on Dyspnea and Endurance in Chronic Hypoxemic Patients with COPD: A Randomized Crossover Trial
title_short	Effect of Automated Oxygen Titration during Walking on Dyspnea and Endurance in Chronic Hypoxemic Patients with COPD: A Randomized Crossover Trial
title_full	Effect of Automated Oxygen Titration during Walking on Dyspnea and Endurance in Chronic Hypoxemic Patients with COPD: A Randomized Crossover Trial
title_fullStr	Effect of Automated Oxygen Titration during Walking on Dyspnea and Endurance in Chronic Hypoxemic Patients with COPD: A Randomized Crossover Trial
title_full_unstemmed	Effect of Automated Oxygen Titration during Walking on Dyspnea and Endurance in Chronic Hypoxemic Patients with COPD: A Randomized Crossover Trial
title_sort	effect of automated oxygen titration during walking on dyspnea and endurance in chronic hypoxemic patients with copd: a randomized crossover trial
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/df6b2f3ff46348db8522a359aff91fcd
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Effect of Automated Oxygen Titration during Walking on Dyspnea and Endurance in Chronic Hypoxemic Patients with COPD: A Randomized Crossover Trial

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