Hepatitis B and C virus infection and diabetes mellitus: A cohort study

Abstract The role of hepatitis virus infection in glucose homeostasis is uncertain. We examined the associations between hepatitis B virus (HBV) or hepatitis C virus (HCV) infection and the development of diabetes in a cohort (N = 439,708) of asymptomatic participants in health screening examination...

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Autores principales:	Yun Soo Hong, Yoosoo Chang, Seungho Ryu, Miguel Cainzos-Achirica, Min-Jung Kwon, Yiyi Zhang, Yuni Choi, Jiin Ahn, Sanjay Rampal, Di Zhao, Roberto Pastor-Barriuso, Mariana Lazo, Hocheol Shin, Juhee Cho, Eliseo Guallar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/df6f24b38a3d4f0293a55892239cb181
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spelling	oai:doaj.org-article:df6f24b38a3d4f0293a55892239cb1812021-12-02T16:06:25ZHepatitis B and C virus infection and diabetes mellitus: A cohort study10.1038/s41598-017-04206-62045-2322https://doaj.org/article/df6f24b38a3d4f0293a55892239cb1812017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04206-6https://doaj.org/toc/2045-2322Abstract The role of hepatitis virus infection in glucose homeostasis is uncertain. We examined the associations between hepatitis B virus (HBV) or hepatitis C virus (HCV) infection and the development of diabetes in a cohort (N = 439,708) of asymptomatic participants in health screening examinations. In cross-sectional analyses, the multivariable-adjusted odds ratio for prevalent diabetes comparing hepatitis B surface antigen (HBsAg) (+) to HBsAg (−) participants was 1.17 (95% CI 1.06–1.31; P = 0.003). The corresponding odds ratio comparing hepatitis C antibodies (HCV Ab) (+) to HCV Ab (−) participants was 1.43 (95% CI 1.01–2.02, P = 0.043). In prospective analyses, the multivariable-adjusted hazard ratio for incident diabetes comparing HBsAg (+) to HbsAg (−) participants was 1.23 (95% CI 1.08–1.41; P = 0.007). The number of incident cases of diabetes among HCV Ab (+) participants (10 cases) was too small to reliably estimate the prospective association between HCV infection and diabetes. In this large population at low risk of diabetes, HBV and HCV infections were associated with diabetes prevalence and HBV infection with the risk of incident diabetes. Our studies add evidence suggesting that diabetes is an additional metabolic complication of HBV and HCV infection.Yun Soo HongYoosoo ChangSeungho RyuMiguel Cainzos-AchiricaMin-Jung KwonYiyi ZhangYuni ChoiJiin AhnSanjay RampalDi ZhaoRoberto Pastor-BarriusoMariana LazoHocheol ShinJuhee ChoEliseo GuallarNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yun Soo Hong Yoosoo Chang Seungho Ryu Miguel Cainzos-Achirica Min-Jung Kwon Yiyi Zhang Yuni Choi Jiin Ahn Sanjay Rampal Di Zhao Roberto Pastor-Barriuso Mariana Lazo Hocheol Shin Juhee Cho Eliseo Guallar Hepatitis B and C virus infection and diabetes mellitus: A cohort study
description	Abstract The role of hepatitis virus infection in glucose homeostasis is uncertain. We examined the associations between hepatitis B virus (HBV) or hepatitis C virus (HCV) infection and the development of diabetes in a cohort (N = 439,708) of asymptomatic participants in health screening examinations. In cross-sectional analyses, the multivariable-adjusted odds ratio for prevalent diabetes comparing hepatitis B surface antigen (HBsAg) (+) to HBsAg (−) participants was 1.17 (95% CI 1.06–1.31; P = 0.003). The corresponding odds ratio comparing hepatitis C antibodies (HCV Ab) (+) to HCV Ab (−) participants was 1.43 (95% CI 1.01–2.02, P = 0.043). In prospective analyses, the multivariable-adjusted hazard ratio for incident diabetes comparing HBsAg (+) to HbsAg (−) participants was 1.23 (95% CI 1.08–1.41; P = 0.007). The number of incident cases of diabetes among HCV Ab (+) participants (10 cases) was too small to reliably estimate the prospective association between HCV infection and diabetes. In this large population at low risk of diabetes, HBV and HCV infections were associated with diabetes prevalence and HBV infection with the risk of incident diabetes. Our studies add evidence suggesting that diabetes is an additional metabolic complication of HBV and HCV infection.
format	article
author	Yun Soo Hong Yoosoo Chang Seungho Ryu Miguel Cainzos-Achirica Min-Jung Kwon Yiyi Zhang Yuni Choi Jiin Ahn Sanjay Rampal Di Zhao Roberto Pastor-Barriuso Mariana Lazo Hocheol Shin Juhee Cho Eliseo Guallar
author_facet	Yun Soo Hong Yoosoo Chang Seungho Ryu Miguel Cainzos-Achirica Min-Jung Kwon Yiyi Zhang Yuni Choi Jiin Ahn Sanjay Rampal Di Zhao Roberto Pastor-Barriuso Mariana Lazo Hocheol Shin Juhee Cho Eliseo Guallar
author_sort	Yun Soo Hong
title	Hepatitis B and C virus infection and diabetes mellitus: A cohort study
title_short	Hepatitis B and C virus infection and diabetes mellitus: A cohort study
title_full	Hepatitis B and C virus infection and diabetes mellitus: A cohort study
title_fullStr	Hepatitis B and C virus infection and diabetes mellitus: A cohort study
title_full_unstemmed	Hepatitis B and C virus infection and diabetes mellitus: A cohort study
title_sort	hepatitis b and c virus infection and diabetes mellitus: a cohort study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/df6f24b38a3d4f0293a55892239cb181
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Hepatitis B and C virus infection and diabetes mellitus: A cohort study

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