The effects of caffeine on sleep and maturational markers in the rat.

Adolescence is a critical period for brain maturation during which a massive reorganization of cortical connectivity takes place. In humans, slow wave activity (<4.5 Hz) during NREM sleep was proposed to reflect cortical maturation which relies on use-dependent processes. A stimulant like caffein...

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Autores principales:	Nadja Olini, Salomé Kurth, Reto Huber
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/df6fabf6415b41cfa7ce8ccbe8b4c4df
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spelling	oai:doaj.org-article:df6fabf6415b41cfa7ce8ccbe8b4c4df2021-11-18T08:57:03ZThe effects of caffeine on sleep and maturational markers in the rat.1932-620310.1371/journal.pone.0072539https://doaj.org/article/df6fabf6415b41cfa7ce8ccbe8b4c4df2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24023748/?tool=EBIhttps://doaj.org/toc/1932-6203Adolescence is a critical period for brain maturation during which a massive reorganization of cortical connectivity takes place. In humans, slow wave activity (<4.5 Hz) during NREM sleep was proposed to reflect cortical maturation which relies on use-dependent processes. A stimulant like caffeine, whose consumption has recently increased especially in adolescents, is known to affect sleep wake regulation. The goal of this study was to establish a rat model allowing to assess the relationship between cortical maturation and sleep and to further investigate how these parameters are affected by caffeine consumption. To do so, we assessed sleep and markers of maturation by electrophysiological recordings, behavioral and structural readouts in the juvenile rat. Our results show that sleep slow wave activity follows a similar inverted U-shape trajectory as already known in humans. Caffeine treatment exerted short-term stimulating effects and altered the trajectory of slow wave activity. Moreover, caffeine affected behavioral and structural markers of maturation. Thus, caffeine consumption during a critical developmental period shows long lasting effects on sleep and brain maturation.Nadja OliniSalomé KurthReto HuberPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e72539 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nadja Olini Salomé Kurth Reto Huber The effects of caffeine on sleep and maturational markers in the rat.
description	Adolescence is a critical period for brain maturation during which a massive reorganization of cortical connectivity takes place. In humans, slow wave activity (<4.5 Hz) during NREM sleep was proposed to reflect cortical maturation which relies on use-dependent processes. A stimulant like caffeine, whose consumption has recently increased especially in adolescents, is known to affect sleep wake regulation. The goal of this study was to establish a rat model allowing to assess the relationship between cortical maturation and sleep and to further investigate how these parameters are affected by caffeine consumption. To do so, we assessed sleep and markers of maturation by electrophysiological recordings, behavioral and structural readouts in the juvenile rat. Our results show that sleep slow wave activity follows a similar inverted U-shape trajectory as already known in humans. Caffeine treatment exerted short-term stimulating effects and altered the trajectory of slow wave activity. Moreover, caffeine affected behavioral and structural markers of maturation. Thus, caffeine consumption during a critical developmental period shows long lasting effects on sleep and brain maturation.
format	article
author	Nadja Olini Salomé Kurth Reto Huber
author_facet	Nadja Olini Salomé Kurth Reto Huber
author_sort	Nadja Olini
title	The effects of caffeine on sleep and maturational markers in the rat.
title_short	The effects of caffeine on sleep and maturational markers in the rat.
title_full	The effects of caffeine on sleep and maturational markers in the rat.
title_fullStr	The effects of caffeine on sleep and maturational markers in the rat.
title_full_unstemmed	The effects of caffeine on sleep and maturational markers in the rat.
title_sort	effects of caffeine on sleep and maturational markers in the rat.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/df6fabf6415b41cfa7ce8ccbe8b4c4df
work_keys_str_mv	AT nadjaolini theeffectsofcaffeineonsleepandmaturationalmarkersintherat AT salomekurth theeffectsofcaffeineonsleepandmaturationalmarkersintherat AT retohuber theeffectsofcaffeineonsleepandmaturationalmarkersintherat AT nadjaolini effectsofcaffeineonsleepandmaturationalmarkersintherat AT salomekurth effectsofcaffeineonsleepandmaturationalmarkersintherat AT retohuber effectsofcaffeineonsleepandmaturationalmarkersintherat
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The effects of caffeine on sleep and maturational markers in the rat.

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