ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane

ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane

ORP5/8 are endoplasmic reticulum (ER) membrane proteins implicated in lipid trafficking that localize to ER-plasma membrane (PM) contacts and maintain membrane homeostasis. Here the authors show that PtdIns(4,5)P 2 plays a critical role in the targeting and function of ORP5/8 at the PM.

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Autores principales: Rajesh Ghai, Ximing Du, Huan Wang, Jiangqing Dong, Charles Ferguson, Andrew J. Brown, Robert G. Parton, Jia-Wei Wu, Hongyuan Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/df6fc894509848fab3fe25b78c872533
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spelling oai:doaj.org-article:df6fc894509848fab3fe25b78c8725332021-12-02T17:06:24ZORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane10.1038/s41467-017-00861-52041-1723https://doaj.org/article/df6fc894509848fab3fe25b78c8725332017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00861-5https://doaj.org/toc/2041-1723ORP5/8 are endoplasmic reticulum (ER) membrane proteins implicated in lipid trafficking that localize to ER-plasma membrane (PM) contacts and maintain membrane homeostasis. Here the authors show that PtdIns(4,5)P 2 plays a critical role in the targeting and function of ORP5/8 at the PM.Rajesh GhaiXiming DuHuan WangJiangqing DongCharles FergusonAndrew J. BrownRobert G. PartonJia-Wei WuHongyuan YangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Rajesh Ghai
Ximing Du
Huan Wang
Jiangqing Dong
Charles Ferguson
Andrew J. Brown
Robert G. Parton
Jia-Wei Wu
Hongyuan Yang
ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane
description ORP5/8 are endoplasmic reticulum (ER) membrane proteins implicated in lipid trafficking that localize to ER-plasma membrane (PM) contacts and maintain membrane homeostasis. Here the authors show that PtdIns(4,5)P 2 plays a critical role in the targeting and function of ORP5/8 at the PM.
format article
author Rajesh Ghai
Ximing Du
Huan Wang
Jiangqing Dong
Charles Ferguson
Andrew J. Brown
Robert G. Parton
Jia-Wei Wu
Hongyuan Yang
author_facet Rajesh Ghai
Ximing Du
Huan Wang
Jiangqing Dong
Charles Ferguson
Andrew J. Brown
Robert G. Parton
Jia-Wei Wu
Hongyuan Yang
author_sort Rajesh Ghai
title ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane
title_short ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane
title_full ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane
title_fullStr ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane
title_full_unstemmed ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane
title_sort orp5 and orp8 bind phosphatidylinositol-4, 5-biphosphate (ptdins(4,5)p 2) and regulate its level at the plasma membrane
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/df6fc894509848fab3fe25b78c872533
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