Role of hepatitis D virus infection in development of hepatocellular carcinoma among chronic hepatitis B patients treated with nucleotide/nucleoside analogues

Abstract Hepatitis D virus (HDV) infection increases the risk of hepatocellular carcinoma (HCC) in the natural course of chronic hepatitis B (CHB) patients. Its role in patients treated with nucleotide/nucleoside analogues (NAs) is unclear. We aimed to study the role of hepatitis D in the developmen...

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Autores principales:	Tyng-Yuan Jang, Yu-Ju Wei, Ta-Wei Liu, Ming-Lun Yeh, Shu-Fen Liu, Cheng-Ting Hsu, Po-Yao Hsu, Yi-Hung Lin, Po-Cheng Liang, Meng-Hsuan Hsieh, Yu-Min Ko, Yi-Shan Tsai, Kuan-Yu Chen, Ching-Chih Lin, Pei-Chien Tsai, Shu-Chi Wang, Ching-I. Huang, Zu-Yau Lin, Shinn-Cherng Chen, Wan-Long Chuang, Jee-Fu Huang, Chia-Yen Dai, Chung-Feng Huang, Ming-Lung Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/df70726873da4e8aa1cc719caa2ada9b
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spelling	oai:doaj.org-article:df70726873da4e8aa1cc719caa2ada9b2021-12-02T14:27:53ZRole of hepatitis D virus infection in development of hepatocellular carcinoma among chronic hepatitis B patients treated with nucleotide/nucleoside analogues10.1038/s41598-021-87679-w2045-2322https://doaj.org/article/df70726873da4e8aa1cc719caa2ada9b2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87679-whttps://doaj.org/toc/2045-2322Abstract Hepatitis D virus (HDV) infection increases the risk of hepatocellular carcinoma (HCC) in the natural course of chronic hepatitis B (CHB) patients. Its role in patients treated with nucleotide/nucleoside analogues (NAs) is unclear. We aimed to study the role of hepatitis D in the development of HCC in CHB patients treated with NAs. Altogether, 1349 CHB patients treated with NAs were tested for anti-HDV antibody and RNA. The incidence and risk factors of HCC development were analyzed. Rates of anti-HDV and HDV RNA positivity were 2.3% and 1.0%, respectively. The annual incidence of HCC was 1.4 per 100 person-years after a follow-up period of over 5409.5 person-years. The strongest factor association with HCC development was liver cirrhosis (hazard ratio [HR]/95% confidence interval [CI] 9.98/5.11–19.46, P < 0.001), followed by HDV RNA positivity (HR/ CI 5.73/1.35–24.29, P = 0.02), age > 50 years old (HR/CI 3.64/2.03–6.54, P < 0.001), male gender (HR/CI 2.69/1.29–5.60, P: 0.01), and body mass index (BMI, HR/CI 1.11/1.03–1.18, P = 0.004). The 5-year cumulative incidence of HCC was 7.3% for patients with HDV RNA negativity compared to that of 22.2% for patients with HDV RNA positivity (P = 0.01). In the subgroup of cirrhotic patients, the factors associated with HCC development were HDV RNA positivity (HR/CI 4.45/1.04–19.09, P = 0.04) and BMI (HR/CI 1.11/1.03–1.19, P = 0.01). HDV viremia played a crucial role in HCC development in CHB patients who underwent NA therapy.Tyng-Yuan JangYu-Ju WeiTa-Wei LiuMing-Lun YehShu-Fen LiuCheng-Ting HsuPo-Yao HsuYi-Hung LinPo-Cheng LiangMeng-Hsuan HsiehYu-Min KoYi-Shan TsaiKuan-Yu ChenChing-Chih LinPei-Chien TsaiShu-Chi WangChing-I. HuangZu-Yau LinShinn-Cherng ChenWan-Long ChuangJee-Fu HuangChia-Yen DaiChung-Feng HuangMing-Lung YuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tyng-Yuan Jang Yu-Ju Wei Ta-Wei Liu Ming-Lun Yeh Shu-Fen Liu Cheng-Ting Hsu Po-Yao Hsu Yi-Hung Lin Po-Cheng Liang Meng-Hsuan Hsieh Yu-Min Ko Yi-Shan Tsai Kuan-Yu Chen Ching-Chih Lin Pei-Chien Tsai Shu-Chi Wang Ching-I. Huang Zu-Yau Lin Shinn-Cherng Chen Wan-Long Chuang Jee-Fu Huang Chia-Yen Dai Chung-Feng Huang Ming-Lung Yu Role of hepatitis D virus infection in development of hepatocellular carcinoma among chronic hepatitis B patients treated with nucleotide/nucleoside analogues
description	Abstract Hepatitis D virus (HDV) infection increases the risk of hepatocellular carcinoma (HCC) in the natural course of chronic hepatitis B (CHB) patients. Its role in patients treated with nucleotide/nucleoside analogues (NAs) is unclear. We aimed to study the role of hepatitis D in the development of HCC in CHB patients treated with NAs. Altogether, 1349 CHB patients treated with NAs were tested for anti-HDV antibody and RNA. The incidence and risk factors of HCC development were analyzed. Rates of anti-HDV and HDV RNA positivity were 2.3% and 1.0%, respectively. The annual incidence of HCC was 1.4 per 100 person-years after a follow-up period of over 5409.5 person-years. The strongest factor association with HCC development was liver cirrhosis (hazard ratio [HR]/95% confidence interval [CI] 9.98/5.11–19.46, P < 0.001), followed by HDV RNA positivity (HR/ CI 5.73/1.35–24.29, P = 0.02), age > 50 years old (HR/CI 3.64/2.03–6.54, P < 0.001), male gender (HR/CI 2.69/1.29–5.60, P: 0.01), and body mass index (BMI, HR/CI 1.11/1.03–1.18, P = 0.004). The 5-year cumulative incidence of HCC was 7.3% for patients with HDV RNA negativity compared to that of 22.2% for patients with HDV RNA positivity (P = 0.01). In the subgroup of cirrhotic patients, the factors associated with HCC development were HDV RNA positivity (HR/CI 4.45/1.04–19.09, P = 0.04) and BMI (HR/CI 1.11/1.03–1.19, P = 0.01). HDV viremia played a crucial role in HCC development in CHB patients who underwent NA therapy.
format	article
author	Tyng-Yuan Jang Yu-Ju Wei Ta-Wei Liu Ming-Lun Yeh Shu-Fen Liu Cheng-Ting Hsu Po-Yao Hsu Yi-Hung Lin Po-Cheng Liang Meng-Hsuan Hsieh Yu-Min Ko Yi-Shan Tsai Kuan-Yu Chen Ching-Chih Lin Pei-Chien Tsai Shu-Chi Wang Ching-I. Huang Zu-Yau Lin Shinn-Cherng Chen Wan-Long Chuang Jee-Fu Huang Chia-Yen Dai Chung-Feng Huang Ming-Lung Yu
author_facet	Tyng-Yuan Jang Yu-Ju Wei Ta-Wei Liu Ming-Lun Yeh Shu-Fen Liu Cheng-Ting Hsu Po-Yao Hsu Yi-Hung Lin Po-Cheng Liang Meng-Hsuan Hsieh Yu-Min Ko Yi-Shan Tsai Kuan-Yu Chen Ching-Chih Lin Pei-Chien Tsai Shu-Chi Wang Ching-I. Huang Zu-Yau Lin Shinn-Cherng Chen Wan-Long Chuang Jee-Fu Huang Chia-Yen Dai Chung-Feng Huang Ming-Lung Yu
author_sort	Tyng-Yuan Jang
title	Role of hepatitis D virus infection in development of hepatocellular carcinoma among chronic hepatitis B patients treated with nucleotide/nucleoside analogues
title_short	Role of hepatitis D virus infection in development of hepatocellular carcinoma among chronic hepatitis B patients treated with nucleotide/nucleoside analogues
title_full	Role of hepatitis D virus infection in development of hepatocellular carcinoma among chronic hepatitis B patients treated with nucleotide/nucleoside analogues
title_fullStr	Role of hepatitis D virus infection in development of hepatocellular carcinoma among chronic hepatitis B patients treated with nucleotide/nucleoside analogues
title_full_unstemmed	Role of hepatitis D virus infection in development of hepatocellular carcinoma among chronic hepatitis B patients treated with nucleotide/nucleoside analogues
title_sort	role of hepatitis d virus infection in development of hepatocellular carcinoma among chronic hepatitis b patients treated with nucleotide/nucleoside analogues
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/df70726873da4e8aa1cc719caa2ada9b
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Role of hepatitis D virus infection in development of hepatocellular carcinoma among chronic hepatitis B patients treated with nucleotide/nucleoside analogues

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