p62 overexpression induces TDP-43 cytoplasmic mislocalisation, aggregation and cleavage and neuronal death

p62 overexpression induces TDP-43 cytoplasmic mislocalisation, aggregation and cleavage and neuronal death

Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) that exist on a spectrum of neurodegenerative disease. A hallmark of pathology is cytoplasmic TDP-43 aggregates within neurons, observed in 97% of ALS cases and ~ 50% of FTLD cases. This mislocalisation from th...

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Autores principales: A. D. Foster, L. L. Flynn, C. Cluning, F. Cheng, J. M. Davidson, A. Lee, N. Polain, R. Mejzini, N. Farrawell, J. J. Yerbury, R. Layfield, P. A. Akkari, S. L. Rea
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/df72a4378b5f4a91bdcc3aec3c0d13ff
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