Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance

The antibiotic resistance crisis calls for new ways of restricting the ability of bacteria to evolve resistance. Here, Lukačišinová et al. perform highly controlled evolution experiments in E. coli strains to identify genetic perturbations that strongly limit the evolution of antibiotic resistance t...

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Auteurs principaux:	Marta Lukačišinová, Booshini Fernando, Tobias Bollenbach
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/df72a91427cc44d6b277ce9d4f48db76
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spelling	oai:doaj.org-article:df72a91427cc44d6b277ce9d4f48db762021-12-02T17:40:33ZHighly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance10.1038/s41467-020-16932-z2041-1723https://doaj.org/article/df72a91427cc44d6b277ce9d4f48db762020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16932-zhttps://doaj.org/toc/2041-1723The antibiotic resistance crisis calls for new ways of restricting the ability of bacteria to evolve resistance. Here, Lukačišinová et al. perform highly controlled evolution experiments in E. coli strains to identify genetic perturbations that strongly limit the evolution of antibiotic resistance through epistasis.Marta LukačišinováBooshini FernandoTobias BollenbachNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marta Lukačišinová Booshini Fernando Tobias Bollenbach Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
description	The antibiotic resistance crisis calls for new ways of restricting the ability of bacteria to evolve resistance. Here, Lukačišinová et al. perform highly controlled evolution experiments in E. coli strains to identify genetic perturbations that strongly limit the evolution of antibiotic resistance through epistasis.
format	article
author	Marta Lukačišinová Booshini Fernando Tobias Bollenbach
author_facet	Marta Lukačišinová Booshini Fernando Tobias Bollenbach
author_sort	Marta Lukačišinová
title	Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
title_short	Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
title_full	Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
title_fullStr	Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
title_full_unstemmed	Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
title_sort	highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/df72a91427cc44d6b277ce9d4f48db76
work_keys_str_mv	AT martalukacisinova highlyparallellabevolutionrevealsthatepistasiscancurbtheevolutionofantibioticresistance AT booshinifernando highlyparallellabevolutionrevealsthatepistasiscancurbtheevolutionofantibioticresistance AT tobiasbollenbach highlyparallellabevolutionrevealsthatepistasiscancurbtheevolutionofantibioticresistance
_version_	1718379795893452800

Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance

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