Formulation and antimicrobial activity evaluation of a 0.2% chlorhexidine canine mouthwash with essential oils

Background: Periodontal disease is the infection and inflammation of the gums, bones, and tissues involved in teeth support, and it is one of the most common diseases affecting pet dogs. Essential oils have shown antimicrobial activity against bacteria causing periodontal disease; therefore, they a...

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Autores principales:	German Madrigal Redondo, Daniela Gonzalez Corrales, Marianela Chavarria Rojas, Tatiana Monge Quiros, Wendy Cruz Sibaja, Norman Rojas Campos
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2021
Materias:	periodontitis microemulsion oregano thyme chlorhexidine essential oil Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/df7309db407d4dcdbbd78675abee310d
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spelling	oai:doaj.org-article:df7309db407d4dcdbbd78675abee310d2021-12-02T19:42:44ZFormulation and antimicrobial activity evaluation of a 0.2% chlorhexidine canine mouthwash with essential oils10.17533/udea.vitae.v28n1a3417030121-40042145-2660https://doaj.org/article/df7309db407d4dcdbbd78675abee310d2021-03-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/341703https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660 Background: Periodontal disease is the infection and inflammation of the gums, bones, and tissues involved in teeth support, and it is one of the most common diseases affecting pet dogs. Essential oils have shown antimicrobial activity against bacteria causing periodontal disease; therefore, they are considered potential therapeutic agents. Objectives: The main objective was to formulate and evaluate the antimicrobial activity of a 0.2% chlorhexidine canine mouthwash with essential oils. Methods: Three microemulsion formulations were obtained by constructing a pseudo-ternary phase diagram using the phase titration method. Different surfactant agents were evaluated, and hydrogenated castor oil was selected as the emulsifier agent. The antimicrobial activity of oregano essential oil (Origanum vulgare), thyme essential oil (Thymus vulgaris), and the three formulations were evaluated against Staphylococcus aureus, Streptococcus mutans, Streptococcus salivarius, and Escherichia coli. Results: Pure thyme and oregano essential oils showed higher antimicrobial activity than a 0,2% chlorhexidine solution. The formulations with essential oils plus chlorhexidine and chlorhexidine alone showed antimicrobial activity. The formulation containing only essential oils did not show antimicrobial activity. Conclusions: A canine mouthwash was formulated with chlorhexidine and thyme and oregano essential oil. Based on the evaluation of antimicrobial activity, two of the proposed formulations could be a therapeutic option to reduce the risk and prevent periodontal disease in canines. German Madrigal Redondo Daniela Gonzalez Corrales Marianela Chavarria Rojas Tatiana Monge Quiros Wendy Cruz Sibaja Norman Rojas Campos Universidad de Antioquiaarticleperiodontitismicroemulsionoreganothymechlorhexidineessential oilFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 28, Iss 01 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	periodontitis microemulsion oregano thyme chlorhexidine essential oil Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	periodontitis microemulsion oregano thyme chlorhexidine essential oil Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 German Madrigal Redondo Daniela Gonzalez Corrales Marianela Chavarria Rojas Tatiana Monge Quiros Wendy Cruz Sibaja Norman Rojas Campos Formulation and antimicrobial activity evaluation of a 0.2% chlorhexidine canine mouthwash with essential oils
description	Background: Periodontal disease is the infection and inflammation of the gums, bones, and tissues involved in teeth support, and it is one of the most common diseases affecting pet dogs. Essential oils have shown antimicrobial activity against bacteria causing periodontal disease; therefore, they are considered potential therapeutic agents. Objectives: The main objective was to formulate and evaluate the antimicrobial activity of a 0.2% chlorhexidine canine mouthwash with essential oils. Methods: Three microemulsion formulations were obtained by constructing a pseudo-ternary phase diagram using the phase titration method. Different surfactant agents were evaluated, and hydrogenated castor oil was selected as the emulsifier agent. The antimicrobial activity of oregano essential oil (Origanum vulgare), thyme essential oil (Thymus vulgaris), and the three formulations were evaluated against Staphylococcus aureus, Streptococcus mutans, Streptococcus salivarius, and Escherichia coli. Results: Pure thyme and oregano essential oils showed higher antimicrobial activity than a 0,2% chlorhexidine solution. The formulations with essential oils plus chlorhexidine and chlorhexidine alone showed antimicrobial activity. The formulation containing only essential oils did not show antimicrobial activity. Conclusions: A canine mouthwash was formulated with chlorhexidine and thyme and oregano essential oil. Based on the evaluation of antimicrobial activity, two of the proposed formulations could be a therapeutic option to reduce the risk and prevent periodontal disease in canines.
format	article
author	German Madrigal Redondo Daniela Gonzalez Corrales Marianela Chavarria Rojas Tatiana Monge Quiros Wendy Cruz Sibaja Norman Rojas Campos
author_facet	German Madrigal Redondo Daniela Gonzalez Corrales Marianela Chavarria Rojas Tatiana Monge Quiros Wendy Cruz Sibaja Norman Rojas Campos
author_sort	German Madrigal Redondo
title	Formulation and antimicrobial activity evaluation of a 0.2% chlorhexidine canine mouthwash with essential oils
title_short	Formulation and antimicrobial activity evaluation of a 0.2% chlorhexidine canine mouthwash with essential oils
title_full	Formulation and antimicrobial activity evaluation of a 0.2% chlorhexidine canine mouthwash with essential oils
title_fullStr	Formulation and antimicrobial activity evaluation of a 0.2% chlorhexidine canine mouthwash with essential oils
title_full_unstemmed	Formulation and antimicrobial activity evaluation of a 0.2% chlorhexidine canine mouthwash with essential oils
title_sort	formulation and antimicrobial activity evaluation of a 0.2% chlorhexidine canine mouthwash with essential oils
publisher	Universidad de Antioquia
publishDate	2021
url	https://doaj.org/article/df7309db407d4dcdbbd78675abee310d
work_keys_str_mv	AT germanmadrigalredondo formulationandantimicrobialactivityevaluationofa02chlorhexidinecaninemouthwashwithessentialoils AT danielagonzalezcorrales formulationandantimicrobialactivityevaluationofa02chlorhexidinecaninemouthwashwithessentialoils AT marianelachavarriarojas formulationandantimicrobialactivityevaluationofa02chlorhexidinecaninemouthwashwithessentialoils AT tatianamongequiros formulationandantimicrobialactivityevaluationofa02chlorhexidinecaninemouthwashwithessentialoils AT wendycruzsibaja formulationandantimicrobialactivityevaluationofa02chlorhexidinecaninemouthwashwithessentialoils AT normanrojascampos formulationandantimicrobialactivityevaluationofa02chlorhexidinecaninemouthwashwithessentialoils
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Formulation and antimicrobial activity evaluation of a 0.2% chlorhexidine canine mouthwash with essential oils

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