Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans

The molecular mechanism of axon regeneration after injury is poorly understood. Here the authors show that in C. elegans, the HIF-1 transcription factor induces ectopic synthesis of serotonin in severed ‘non-serotonergic’ neurons and that serotonin activates downstream signaling pathways leading to...

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Autores principales:	Tanimul Alam, Hiroki Maruyama, Chun Li, Strahil Iv. Pastuhov, Paola Nix, Michael Bastiani, Naoki Hisamoto, Kunihiro Matsumoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/df74211fbd2e45be8c4c87f6e1c01ced
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spelling	oai:doaj.org-article:df74211fbd2e45be8c4c87f6e1c01ced2021-12-02T16:57:02ZAxotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans10.1038/ncomms103882041-1723https://doaj.org/article/df74211fbd2e45be8c4c87f6e1c01ced2016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10388https://doaj.org/toc/2041-1723The molecular mechanism of axon regeneration after injury is poorly understood. Here the authors show that in C. elegans, the HIF-1 transcription factor induces ectopic synthesis of serotonin in severed ‘non-serotonergic’ neurons and that serotonin activates downstream signaling pathways leading to axon regeneration.Tanimul AlamHiroki MaruyamaChun LiStrahil Iv. PastuhovPaola NixMichael BastianiNaoki HisamotoKunihiro MatsumotoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tanimul Alam Hiroki Maruyama Chun Li Strahil Iv. Pastuhov Paola Nix Michael Bastiani Naoki Hisamoto Kunihiro Matsumoto Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans
description	The molecular mechanism of axon regeneration after injury is poorly understood. Here the authors show that in C. elegans, the HIF-1 transcription factor induces ectopic synthesis of serotonin in severed ‘non-serotonergic’ neurons and that serotonin activates downstream signaling pathways leading to axon regeneration.
format	article
author	Tanimul Alam Hiroki Maruyama Chun Li Strahil Iv. Pastuhov Paola Nix Michael Bastiani Naoki Hisamoto Kunihiro Matsumoto
author_facet	Tanimul Alam Hiroki Maruyama Chun Li Strahil Iv. Pastuhov Paola Nix Michael Bastiani Naoki Hisamoto Kunihiro Matsumoto
author_sort	Tanimul Alam
title	Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans
title_short	Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans
title_full	Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans
title_fullStr	Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans
title_full_unstemmed	Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans
title_sort	axotomy-induced hif-serotonin signalling axis promotes axon regeneration in c. elegans
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/df74211fbd2e45be8c4c87f6e1c01ced
work_keys_str_mv	AT tanimulalam axotomyinducedhifserotoninsignallingaxispromotesaxonregenerationincelegans AT hirokimaruyama axotomyinducedhifserotoninsignallingaxispromotesaxonregenerationincelegans AT chunli axotomyinducedhifserotoninsignallingaxispromotesaxonregenerationincelegans AT strahilivpastuhov axotomyinducedhifserotoninsignallingaxispromotesaxonregenerationincelegans AT paolanix axotomyinducedhifserotoninsignallingaxispromotesaxonregenerationincelegans AT michaelbastiani axotomyinducedhifserotoninsignallingaxispromotesaxonregenerationincelegans AT naokihisamoto axotomyinducedhifserotoninsignallingaxispromotesaxonregenerationincelegans AT kunihiromatsumoto axotomyinducedhifserotoninsignallingaxispromotesaxonregenerationincelegans
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Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans

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