Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans

Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans

The molecular mechanism of axon regeneration after injury is poorly understood. Here the authors show that in C. elegans, the HIF-1 transcription factor induces ectopic synthesis of serotonin in severed ‘non-serotonergic’ neurons and that serotonin activates downstream signaling pathways leading to...

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Autores principales: Tanimul Alam, Hiroki Maruyama, Chun Li, Strahil Iv. Pastuhov, Paola Nix, Michael Bastiani, Naoki Hisamoto, Kunihiro Matsumoto
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/df74211fbd2e45be8c4c87f6e1c01ced
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