STUDYING PSYCHOIMMUNOMODULATING EFFECT OF SUCCINATE PHENOTROPIL IN EXPERIMENTAL MODEL
Аbstract. Psychoimmunomodulating properties of phenotropil succinate, a new phenotropil derivative, were studied in a model of cyclophosphamide-induced immunodepression and lypopolysaccharideinduced immune stress, following intraperitoneal injections of the drug at differen...
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| Autores principales: | , , , , , , |
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| Formato: | article |
| Lenguaje: | RU |
| Publicado: |
SPb RAACI
2014
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/df75a3552f4a49b18061458d92819656 |
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| Sumario: | Аbstract. Psychoimmunomodulating properties of phenotropil succinate, a new phenotropil derivative, were studied in a model of cyclophosphamide-induced immunodepression and lypopolysaccharideinduced immune stress, following intraperitoneal injections of the drug at different schedules (from a single injection up to a 7-day course), and at varying doses (25 mg/kg, 50 mg/kg, and 100 mg/kg). It was found that the studied substance shows a clear ability to eliminate disorders of various immune compartments. Moreover, phenotropil succinate was able to restore behavioral reactions in “Suоk-test”. These results provide evidence for development of this substance aimed for correction of neuroimmune disturbances. (Med. Immunol., 2011, vol. 13, N 1, pp 55-60) |
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