STUDYING PSYCHOIMMUNOMODULATING EFFECT OF SUCCINATE PHENOTROPIL IN EXPERIMENTAL MODEL

Аbstract. Psychoimmunomodulating properties of phenotropil succinate, a new phenotropil derivative, were studied in a model of cyclophosphamide-induced immunodepression and lypopolysaccharideinduced immune stress, following intraperitoneal injections of the drug at differen...

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Autores principales:	M. A. Samotrueva, I. N. Tiurenkov, D. L. Tioplyi, T. K. Serezhnikova, M. M. Magomadov, V. M. Berestovitskaya, O. S. Vasilieva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	succinate phenotropil neuroimmune correction “immune” stress immunodepression cyclophosphamide lypopolysaccharide in vivo model Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/df75a3552f4a49b18061458d92819656
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spelling	oai:doaj.org-article:df75a3552f4a49b18061458d928196562021-11-18T08:03:41ZSTUDYING PSYCHOIMMUNOMODULATING EFFECT OF SUCCINATE PHENOTROPIL IN EXPERIMENTAL MODEL1563-06252313-741X10.15789/1563-0625-2011-1-55-60https://doaj.org/article/df75a3552f4a49b18061458d928196562014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/407https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XАbstract. Psychoimmunomodulating properties of phenotropil succinate, a new phenotropil derivative, were studied in a model of cyclophosphamide-induced immunodepression and lypopolysaccharideinduced immune stress, following intraperitoneal injections of the drug at different schedules (from a single injection up to a 7-day course), and at varying doses (25 mg/kg, 50 mg/kg, and 100 mg/kg). It was found that the studied substance shows a clear ability to eliminate disorders of various immune compartments. Moreover, phenotropil succinate was able to restore behavioral reactions in “Suоk-test”. These results provide evidence for development of this substance aimed for correction of neuroimmune disturbances. (Med. Immunol., 2011, vol. 13, N 1, pp 55-60)M. A. SamotruevaI. N. TiurenkovD. L. TioplyiT. K. SerezhnikovaM. M. MagomadovV. M. BerestovitskayaO. S. VasilievaSPb RAACIarticlesuccinate phenotropilneuroimmune correction“immune” stressimmunodepressioncyclophosphamidelypopolysaccharidein vivo modelImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 1, Pp 55-60 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	succinate phenotropil neuroimmune correction “immune” stress immunodepression cyclophosphamide lypopolysaccharide in vivo model Immunologic diseases. Allergy RC581-607
spellingShingle	succinate phenotropil neuroimmune correction “immune” stress immunodepression cyclophosphamide lypopolysaccharide in vivo model Immunologic diseases. Allergy RC581-607 M. A. Samotrueva I. N. Tiurenkov D. L. Tioplyi T. K. Serezhnikova M. M. Magomadov V. M. Berestovitskaya O. S. Vasilieva STUDYING PSYCHOIMMUNOMODULATING EFFECT OF SUCCINATE PHENOTROPIL IN EXPERIMENTAL MODEL
description	Аbstract. Psychoimmunomodulating properties of phenotropil succinate, a new phenotropil derivative, were studied in a model of cyclophosphamide-induced immunodepression and lypopolysaccharideinduced immune stress, following intraperitoneal injections of the drug at different schedules (from a single injection up to a 7-day course), and at varying doses (25 mg/kg, 50 mg/kg, and 100 mg/kg). It was found that the studied substance shows a clear ability to eliminate disorders of various immune compartments. Moreover, phenotropil succinate was able to restore behavioral reactions in “Suоk-test”. These results provide evidence for development of this substance aimed for correction of neuroimmune disturbances. (Med. Immunol., 2011, vol. 13, N 1, pp 55-60)
format	article
author	M. A. Samotrueva I. N. Tiurenkov D. L. Tioplyi T. K. Serezhnikova M. M. Magomadov V. M. Berestovitskaya O. S. Vasilieva
author_facet	M. A. Samotrueva I. N. Tiurenkov D. L. Tioplyi T. K. Serezhnikova M. M. Magomadov V. M. Berestovitskaya O. S. Vasilieva
author_sort	M. A. Samotrueva
title	STUDYING PSYCHOIMMUNOMODULATING EFFECT OF SUCCINATE PHENOTROPIL IN EXPERIMENTAL MODEL
title_short	STUDYING PSYCHOIMMUNOMODULATING EFFECT OF SUCCINATE PHENOTROPIL IN EXPERIMENTAL MODEL
title_full	STUDYING PSYCHOIMMUNOMODULATING EFFECT OF SUCCINATE PHENOTROPIL IN EXPERIMENTAL MODEL
title_fullStr	STUDYING PSYCHOIMMUNOMODULATING EFFECT OF SUCCINATE PHENOTROPIL IN EXPERIMENTAL MODEL
title_full_unstemmed	STUDYING PSYCHOIMMUNOMODULATING EFFECT OF SUCCINATE PHENOTROPIL IN EXPERIMENTAL MODEL
title_sort	studying psychoimmunomodulating effect of succinate phenotropil in experimental model
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/df75a3552f4a49b18061458d92819656
work_keys_str_mv	AT masamotrueva studyingpsychoimmunomodulatingeffectofsuccinatephenotropilinexperimentalmodel AT intiurenkov studyingpsychoimmunomodulatingeffectofsuccinatephenotropilinexperimentalmodel AT dltioplyi studyingpsychoimmunomodulatingeffectofsuccinatephenotropilinexperimentalmodel AT tkserezhnikova studyingpsychoimmunomodulatingeffectofsuccinatephenotropilinexperimentalmodel AT mmmagomadov studyingpsychoimmunomodulatingeffectofsuccinatephenotropilinexperimentalmodel AT vmberestovitskaya studyingpsychoimmunomodulatingeffectofsuccinatephenotropilinexperimentalmodel AT osvasilieva studyingpsychoimmunomodulatingeffectofsuccinatephenotropilinexperimentalmodel
_version_	1718422512781492224

STUDYING PSYCHOIMMUNOMODULATING EFFECT OF SUCCINATE PHENOTROPIL IN EXPERIMENTAL MODEL

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