Angiopoietin-like 4 is over-expressed in rheumatoid arthritis patients: association with pathological bone resorption.

<h4>Introduction</h4>Osteoclasts are responsible for the bone loss associated with rheumatoid arthritis (RA). The secreted adipokine angiopoietin-like 4 (ANGPTL4) specifically increases osteoclast-mediated bone resorption. We have investigated expression of ANGPTL4 and its regulatory tra...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Catherine Swales, Nicholas A Athanasou, Helen J Knowles
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/df75ccba4e794687b6ed9f1acbdb6df8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:df75ccba4e794687b6ed9f1acbdb6df8
record_format	dspace
spelling	oai:doaj.org-article:df75ccba4e794687b6ed9f1acbdb6df82021-11-25T05:57:45ZAngiopoietin-like 4 is over-expressed in rheumatoid arthritis patients: association with pathological bone resorption.1932-620310.1371/journal.pone.0109524https://doaj.org/article/df75ccba4e794687b6ed9f1acbdb6df82014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0109524https://doaj.org/toc/1932-6203<h4>Introduction</h4>Osteoclasts are responsible for the bone loss associated with rheumatoid arthritis (RA). The secreted adipokine angiopoietin-like 4 (ANGPTL4) specifically increases osteoclast-mediated bone resorption. We have investigated expression of ANGPTL4 and its regulatory transcription factor, hypoxia-inducible factor-1 alpha (HIF-1α), in osteoclasts and other cells within rheumatoid synovium. We have also examined whether circulating levels of ANGPTL4 differ in RA patients compared with that in normal controls or patients with osteoarthritis (OA).<h4>Results</h4>Immunohistochemical analysis revealed that bone-apposing osteoclasts within the rheumatoid synovium express both ANGPTL4 and HIF-1α. ANGPTL4 was also strongly expressed in synovial lining cells, endothelial cells, stromal cells, CD68+ macrophages and plasma cells within RA synovium. Little ANGPTL4 was evident in normal synovial tissue. This reflected the over-expression of HIF-1α in rheumatoid versus normal synovial tissue. The concentration of ANGPTL4 was higher in both the serum and the synovial fluid of RA patients than in patients with OA or normal controls. High serum ANGPTL4 associated with elevated levels of the serum marker of bone resorption, receptor activator for nuclear factor κB ligand (RANKL).<h4>Conclusions</h4>Over-expression of ANGPTL4 in multiple cell types within the rheumatoid synovium potentially provides a local pool of ANGPTL4 to stimulate osteoclast-mediated bone resorption in RA. Additionally, correlation of high serum ANGPTL4 with circulating RANKL suggests that ANGPTL4 may represent a novel marker for bone destruction in RA.Catherine SwalesNicholas A AthanasouHelen J KnowlesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 10, p e109524 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Catherine Swales Nicholas A Athanasou Helen J Knowles Angiopoietin-like 4 is over-expressed in rheumatoid arthritis patients: association with pathological bone resorption.
description	<h4>Introduction</h4>Osteoclasts are responsible for the bone loss associated with rheumatoid arthritis (RA). The secreted adipokine angiopoietin-like 4 (ANGPTL4) specifically increases osteoclast-mediated bone resorption. We have investigated expression of ANGPTL4 and its regulatory transcription factor, hypoxia-inducible factor-1 alpha (HIF-1α), in osteoclasts and other cells within rheumatoid synovium. We have also examined whether circulating levels of ANGPTL4 differ in RA patients compared with that in normal controls or patients with osteoarthritis (OA).<h4>Results</h4>Immunohistochemical analysis revealed that bone-apposing osteoclasts within the rheumatoid synovium express both ANGPTL4 and HIF-1α. ANGPTL4 was also strongly expressed in synovial lining cells, endothelial cells, stromal cells, CD68+ macrophages and plasma cells within RA synovium. Little ANGPTL4 was evident in normal synovial tissue. This reflected the over-expression of HIF-1α in rheumatoid versus normal synovial tissue. The concentration of ANGPTL4 was higher in both the serum and the synovial fluid of RA patients than in patients with OA or normal controls. High serum ANGPTL4 associated with elevated levels of the serum marker of bone resorption, receptor activator for nuclear factor κB ligand (RANKL).<h4>Conclusions</h4>Over-expression of ANGPTL4 in multiple cell types within the rheumatoid synovium potentially provides a local pool of ANGPTL4 to stimulate osteoclast-mediated bone resorption in RA. Additionally, correlation of high serum ANGPTL4 with circulating RANKL suggests that ANGPTL4 may represent a novel marker for bone destruction in RA.
format	article
author	Catherine Swales Nicholas A Athanasou Helen J Knowles
author_facet	Catherine Swales Nicholas A Athanasou Helen J Knowles
author_sort	Catherine Swales
title	Angiopoietin-like 4 is over-expressed in rheumatoid arthritis patients: association with pathological bone resorption.
title_short	Angiopoietin-like 4 is over-expressed in rheumatoid arthritis patients: association with pathological bone resorption.
title_full	Angiopoietin-like 4 is over-expressed in rheumatoid arthritis patients: association with pathological bone resorption.
title_fullStr	Angiopoietin-like 4 is over-expressed in rheumatoid arthritis patients: association with pathological bone resorption.
title_full_unstemmed	Angiopoietin-like 4 is over-expressed in rheumatoid arthritis patients: association with pathological bone resorption.
title_sort	angiopoietin-like 4 is over-expressed in rheumatoid arthritis patients: association with pathological bone resorption.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/df75ccba4e794687b6ed9f1acbdb6df8
work_keys_str_mv	AT catherineswales angiopoietinlike4isoverexpressedinrheumatoidarthritispatientsassociationwithpathologicalboneresorption AT nicholasaathanasou angiopoietinlike4isoverexpressedinrheumatoidarthritispatientsassociationwithpathologicalboneresorption AT helenjknowles angiopoietinlike4isoverexpressedinrheumatoidarthritispatientsassociationwithpathologicalboneresorption
_version_	1718414372477337600

Angiopoietin-like 4 is over-expressed in rheumatoid arthritis patients: association with pathological bone resorption.

Ejemplares similares