Radioprotective effect of Date syrup on radiation- induced damage in Rats

Abstract Ionizing radiation has cytotoxic and genotoxic effects caused mainly by the oxidative damage induced by free radical release. The need for radioprotectives is increasing to protect normal tissues during radiotherapy. In the present study, we investigated the radioprotective effect of Date s...

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Autores principales:	Shimaa M. Abou-Zeid, Badr E. EL-bialy, Nermeen B. EL-borai, Huda O. AbuBakr, Abdel Monsef A. Elhadary
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/df763bf2617f4e9089c3cfe741a9d5a7
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spelling	oai:doaj.org-article:df763bf2617f4e9089c3cfe741a9d5a72021-12-02T12:31:56ZRadioprotective effect of Date syrup on radiation- induced damage in Rats10.1038/s41598-018-25586-32045-2322https://doaj.org/article/df763bf2617f4e9089c3cfe741a9d5a72018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25586-3https://doaj.org/toc/2045-2322Abstract Ionizing radiation has cytotoxic and genotoxic effects caused mainly by the oxidative damage induced by free radical release. The need for radioprotectives is increasing to protect normal tissues during radiotherapy. In the present study, we investigated the radioprotective effect of Date syrup in rats subjected to whole body radiation at 6 Gy through biochemical, molecular and histopathological analysis. Significant elevations were recorded in the activities of serum ALT, AST, ALP and LDH and in the levels of all lipid profiles parameters, while the level of HDL-C was reduced. The concentration of liver MDA was elevated with depletion of hepatic glutathione (GSH) and catalase. DNA damage was evidenced by increased DNA strand breakage and DNA-protein crosslinks. Significant elevations were observed in the expression of liver TNF-α and serum activity of matrix metalloproteinase (MMP-9). Pretreatment of rats with Date syrup ameliorated the tissue damage induced by radiation as evidenced by the improvement of liver function, antioxidant status and reduction of DNA damage. Besides, liver TNF-α expression and serum MMP-9 activity were reduced. In conclusion, Date syrup could alleviate the toxic effects of ionizing radiation and thus is useful as a radioprotective in radiotherapy regimen.Shimaa M. Abou-ZeidBadr E. EL-bialyNermeen B. EL-boraiHuda O. AbuBakrAbdel Monsef A. ElhadaryNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shimaa M. Abou-Zeid Badr E. EL-bialy Nermeen B. EL-borai Huda O. AbuBakr Abdel Monsef A. Elhadary Radioprotective effect of Date syrup on radiation- induced damage in Rats
description	Abstract Ionizing radiation has cytotoxic and genotoxic effects caused mainly by the oxidative damage induced by free radical release. The need for radioprotectives is increasing to protect normal tissues during radiotherapy. In the present study, we investigated the radioprotective effect of Date syrup in rats subjected to whole body radiation at 6 Gy through biochemical, molecular and histopathological analysis. Significant elevations were recorded in the activities of serum ALT, AST, ALP and LDH and in the levels of all lipid profiles parameters, while the level of HDL-C was reduced. The concentration of liver MDA was elevated with depletion of hepatic glutathione (GSH) and catalase. DNA damage was evidenced by increased DNA strand breakage and DNA-protein crosslinks. Significant elevations were observed in the expression of liver TNF-α and serum activity of matrix metalloproteinase (MMP-9). Pretreatment of rats with Date syrup ameliorated the tissue damage induced by radiation as evidenced by the improvement of liver function, antioxidant status and reduction of DNA damage. Besides, liver TNF-α expression and serum MMP-9 activity were reduced. In conclusion, Date syrup could alleviate the toxic effects of ionizing radiation and thus is useful as a radioprotective in radiotherapy regimen.
format	article
author	Shimaa M. Abou-Zeid Badr E. EL-bialy Nermeen B. EL-borai Huda O. AbuBakr Abdel Monsef A. Elhadary
author_facet	Shimaa M. Abou-Zeid Badr E. EL-bialy Nermeen B. EL-borai Huda O. AbuBakr Abdel Monsef A. Elhadary
author_sort	Shimaa M. Abou-Zeid
title	Radioprotective effect of Date syrup on radiation- induced damage in Rats
title_short	Radioprotective effect of Date syrup on radiation- induced damage in Rats
title_full	Radioprotective effect of Date syrup on radiation- induced damage in Rats
title_fullStr	Radioprotective effect of Date syrup on radiation- induced damage in Rats
title_full_unstemmed	Radioprotective effect of Date syrup on radiation- induced damage in Rats
title_sort	radioprotective effect of date syrup on radiation- induced damage in rats
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/df763bf2617f4e9089c3cfe741a9d5a7
work_keys_str_mv	AT shimaamabouzeid radioprotectiveeffectofdatesyruponradiationinduceddamageinrats AT badreelbialy radioprotectiveeffectofdatesyruponradiationinduceddamageinrats AT nermeenbelborai radioprotectiveeffectofdatesyruponradiationinduceddamageinrats AT hudaoabubakr radioprotectiveeffectofdatesyruponradiationinduceddamageinrats AT abdelmonsefaelhadary radioprotectiveeffectofdatesyruponradiationinduceddamageinrats
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Radioprotective effect of Date syrup on radiation- induced damage in Rats

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