Serum testosterone levels are positively associated with serum anti-mullerian hormone levels in infertile women

Abstract Anti-Mullerian hormone (AMH) and testosterone (T) both play distinct roles in the early stages of folliculogenesis. However, the relationship between serum T and AMH levels is poorly understood. This study aimed to investigate the association between serum T and AMH levels in infertile wome...

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Autores principales:	Li-Te Lin, Chia-Jung Li, Kuan-Hao Tsui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/df78812c067648fabdf74d6971ed0bf4
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spelling	oai:doaj.org-article:df78812c067648fabdf74d6971ed0bf42021-12-02T16:30:24ZSerum testosterone levels are positively associated with serum anti-mullerian hormone levels in infertile women10.1038/s41598-021-85915-x2045-2322https://doaj.org/article/df78812c067648fabdf74d6971ed0bf42021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85915-xhttps://doaj.org/toc/2045-2322Abstract Anti-Mullerian hormone (AMH) and testosterone (T) both play distinct roles in the early stages of folliculogenesis. However, the relationship between serum T and AMH levels is poorly understood. This study aimed to investigate the association between serum T and AMH levels in infertile women. A total of 1935 infertile women aged 20–46 years were included in the cross-sectional study and divided into four quartile groups (Q1 to Q4) based on serum T levels. Compared to the subjects in the highest T quartile (Q4), those in the lowest T quartile (Q1) showed significantly lower AMH levels. After adjustment for age, body weight, body mass index and FSH, increasing T quartile categories were associated with higher AMH levels. Binary logistic regression analyses revealed that the odds for the risk of diminished ovarian reserve (DOR) were 11.44-fold higher in Q1 than in Q4 and the odds for the risk of excess ovarian reserve (EOR) were 10.41-fold higher in Q4 than in Q1. Our data show that serum T levels are positively associated with serum AMH levels and suggest that androgen insufficiency may be a potential risk factor for DOR; androgen excess may lead to EOR in infertile women.Li-Te LinChia-Jung LiKuan-Hao TsuiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Li-Te Lin Chia-Jung Li Kuan-Hao Tsui Serum testosterone levels are positively associated with serum anti-mullerian hormone levels in infertile women
description	Abstract Anti-Mullerian hormone (AMH) and testosterone (T) both play distinct roles in the early stages of folliculogenesis. However, the relationship between serum T and AMH levels is poorly understood. This study aimed to investigate the association between serum T and AMH levels in infertile women. A total of 1935 infertile women aged 20–46 years were included in the cross-sectional study and divided into four quartile groups (Q1 to Q4) based on serum T levels. Compared to the subjects in the highest T quartile (Q4), those in the lowest T quartile (Q1) showed significantly lower AMH levels. After adjustment for age, body weight, body mass index and FSH, increasing T quartile categories were associated with higher AMH levels. Binary logistic regression analyses revealed that the odds for the risk of diminished ovarian reserve (DOR) were 11.44-fold higher in Q1 than in Q4 and the odds for the risk of excess ovarian reserve (EOR) were 10.41-fold higher in Q4 than in Q1. Our data show that serum T levels are positively associated with serum AMH levels and suggest that androgen insufficiency may be a potential risk factor for DOR; androgen excess may lead to EOR in infertile women.
format	article
author	Li-Te Lin Chia-Jung Li Kuan-Hao Tsui
author_facet	Li-Te Lin Chia-Jung Li Kuan-Hao Tsui
author_sort	Li-Te Lin
title	Serum testosterone levels are positively associated with serum anti-mullerian hormone levels in infertile women
title_short	Serum testosterone levels are positively associated with serum anti-mullerian hormone levels in infertile women
title_full	Serum testosterone levels are positively associated with serum anti-mullerian hormone levels in infertile women
title_fullStr	Serum testosterone levels are positively associated with serum anti-mullerian hormone levels in infertile women
title_full_unstemmed	Serum testosterone levels are positively associated with serum anti-mullerian hormone levels in infertile women
title_sort	serum testosterone levels are positively associated with serum anti-mullerian hormone levels in infertile women
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/df78812c067648fabdf74d6971ed0bf4
work_keys_str_mv	AT litelin serumtestosteronelevelsarepositivelyassociatedwithserumantimullerianhormonelevelsininfertilewomen AT chiajungli serumtestosteronelevelsarepositivelyassociatedwithserumantimullerianhormonelevelsininfertilewomen AT kuanhaotsui serumtestosteronelevelsarepositivelyassociatedwithserumantimullerianhormonelevelsininfertilewomen
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Serum testosterone levels are positively associated with serum anti-mullerian hormone levels in infertile women

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