Early diagnosis of genital mucosal melanoma: how good are our dermoscopic criteria?

Background: There are limited studies on the dermoscopic features of mucosal melanoma, particularly early-stage lesions. Described criteria include the presence of blue, gray, or white colors, with a reported sensitivity of 100%. It is unclear if these features will aid in the detection of early mu...

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Autores principales:	Tova Rogers, Melissa Pulitzer, Maria L. Marino, Ashfaq A. Marghoob, Oliver Zivanovic, Michael A. Marchetti
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2016
Materias:	melanoma genital mucosal melanoma dermoscopy Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/df7c95765d0f49beb99cefb3de549f9b
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spelling	oai:doaj.org-article:df7c95765d0f49beb99cefb3de549f9b2021-11-17T08:31:02ZEarly diagnosis of genital mucosal melanoma: how good are our dermoscopic criteria?10.5826/dpc.0604a102160-9381https://doaj.org/article/df7c95765d0f49beb99cefb3de549f9b2016-10-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/145https://doaj.org/toc/2160-9381 Background: There are limited studies on the dermoscopic features of mucosal melanoma, particularly early-stage lesions. Described criteria include the presence of blue, gray, or white colors, with a reported sensitivity of 100%. It is unclear if these features will aid in the detection of early mucosal melanoma or improve diagnostic accuracy compared to naked-eye examination alone. Case: An Asian female in her fifties was referred for evaluation of an asymptomatic, irregularly pigmented patch of the clitoral hood and labia minora of unknown duration. Her past medical history was notable for Stage IV non-small cell lung cancer. She denied a personal or family history of skin cancer. Dermoscopic evaluation of the vulvar lesion revealed heterogeneous brown and black pigmentation mostly composed of thick lines. There were no other colors or structures present. As the differential diagnosis included vulvar melanosis and mucosal melanoma, the patient was recommended to undergo biopsy, which was delayed due to complications from her underlying lung cancer. Repeat dermoscopic imaging performed three months later revealed significant changes concerning for melanoma, including increase in size, asymmetric darkening, and the appearance of structureless areas and central blue and pink colors. Histopathological examination of a biopsy and subsequent resection confirmed the diagnosis of melanoma in situ. Conclusion: Previously described dermoscopic features for mucosal melanoma may not have high sensitivity for early melanomas. Additional studies are needed to define the dermoscopic characteristics of mucosal melanomas that aid in early detection. Health care providers should have a low threshold for biopsy of mucosal lesions that show any clinical or dermoscopic features of melanoma, especially in older women. Tova RogersMelissa PulitzerMaria L. MarinoAshfaq A. MarghoobOliver ZivanovicMichael A. MarchettiMattioli1885articlemelanomagenitalmucosal melanomadermoscopyDermatologyRL1-803ENDermatology Practical & Conceptual (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	melanoma genital mucosal melanoma dermoscopy Dermatology RL1-803
spellingShingle	melanoma genital mucosal melanoma dermoscopy Dermatology RL1-803 Tova Rogers Melissa Pulitzer Maria L. Marino Ashfaq A. Marghoob Oliver Zivanovic Michael A. Marchetti Early diagnosis of genital mucosal melanoma: how good are our dermoscopic criteria?
description	Background: There are limited studies on the dermoscopic features of mucosal melanoma, particularly early-stage lesions. Described criteria include the presence of blue, gray, or white colors, with a reported sensitivity of 100%. It is unclear if these features will aid in the detection of early mucosal melanoma or improve diagnostic accuracy compared to naked-eye examination alone. Case: An Asian female in her fifties was referred for evaluation of an asymptomatic, irregularly pigmented patch of the clitoral hood and labia minora of unknown duration. Her past medical history was notable for Stage IV non-small cell lung cancer. She denied a personal or family history of skin cancer. Dermoscopic evaluation of the vulvar lesion revealed heterogeneous brown and black pigmentation mostly composed of thick lines. There were no other colors or structures present. As the differential diagnosis included vulvar melanosis and mucosal melanoma, the patient was recommended to undergo biopsy, which was delayed due to complications from her underlying lung cancer. Repeat dermoscopic imaging performed three months later revealed significant changes concerning for melanoma, including increase in size, asymmetric darkening, and the appearance of structureless areas and central blue and pink colors. Histopathological examination of a biopsy and subsequent resection confirmed the diagnosis of melanoma in situ. Conclusion: Previously described dermoscopic features for mucosal melanoma may not have high sensitivity for early melanomas. Additional studies are needed to define the dermoscopic characteristics of mucosal melanomas that aid in early detection. Health care providers should have a low threshold for biopsy of mucosal lesions that show any clinical or dermoscopic features of melanoma, especially in older women.
format	article
author	Tova Rogers Melissa Pulitzer Maria L. Marino Ashfaq A. Marghoob Oliver Zivanovic Michael A. Marchetti
author_facet	Tova Rogers Melissa Pulitzer Maria L. Marino Ashfaq A. Marghoob Oliver Zivanovic Michael A. Marchetti
author_sort	Tova Rogers
title	Early diagnosis of genital mucosal melanoma: how good are our dermoscopic criteria?
title_short	Early diagnosis of genital mucosal melanoma: how good are our dermoscopic criteria?
title_full	Early diagnosis of genital mucosal melanoma: how good are our dermoscopic criteria?
title_fullStr	Early diagnosis of genital mucosal melanoma: how good are our dermoscopic criteria?
title_full_unstemmed	Early diagnosis of genital mucosal melanoma: how good are our dermoscopic criteria?
title_sort	early diagnosis of genital mucosal melanoma: how good are our dermoscopic criteria?
publisher	Mattioli1885
publishDate	2016
url	https://doaj.org/article/df7c95765d0f49beb99cefb3de549f9b
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Early diagnosis of genital mucosal melanoma: how good are our dermoscopic criteria?

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