Optic disc vessel density in nonglaucomatous and glaucomatous eyes: an enhanced-depth imaging optical coherence tomography angiography study

Yuji Yoshikawa,1 Takuhei Shoji,1 Junji Kanno,1 Itaru Kimura,1 Masanori Hangai,2 Kei Shinoda1 1Department of Ophthalmology, Saitama Medical University, Saitama, Japan; 2Hangai Eye Institute, Saitama, Japan Purpose: To evaluate the ability of enhanced-depth imaging (EDI) optical coherence tomography...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yoshikawa Y, Shoji T, Kanno J, Kimura I, Hangai M, Shinoda K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	optical coherence tomography angiography enhanced depth imaging vessel density glaucoma severity mean deviation Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/df7e24d130df45eab8e9da43a6b546e1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:df7e24d130df45eab8e9da43a6b546e1
record_format	dspace
spelling	oai:doaj.org-article:df7e24d130df45eab8e9da43a6b546e12021-12-02T03:49:21ZOptic disc vessel density in nonglaucomatous and glaucomatous eyes: an enhanced-depth imaging optical coherence tomography angiography study1177-5483https://doaj.org/article/df7e24d130df45eab8e9da43a6b546e12018-06-01T00:00:00Zhttps://www.dovepress.com/optic-disc-vessel-density-in-nonglaucomatous-and-glaucomatous-eyes-an--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Yuji Yoshikawa,1 Takuhei Shoji,1 Junji Kanno,1 Itaru Kimura,1 Masanori Hangai,2 Kei Shinoda1 1Department of Ophthalmology, Saitama Medical University, Saitama, Japan; 2Hangai Eye Institute, Saitama, Japan Purpose: To evaluate the ability of enhanced-depth imaging (EDI) optical coherence tomography angiography (OCTA) to detect vascular signals inside the glaucomatous optic disc.Patients and methods: Ten glaucomatous eyes of 8 subjects and 11 nonglaucomatous eyes of 7 subjects underwent EDI and conventional OCTA for optic disc analysis. The optic disc vessel density (VD) at maximum scan depth (2 mm) was compared between the 2 methods and between glaucomatous and nonglaucomatous eyes. Regression analysis was used to determine the factors affecting disc VD.Results: The median (25th, 75th percentile) of the visual field mean deviation was –20.5 (–25.1, –13.5) dB in glaucoma. The disc VD measured with the EDI method was significantly greater than that measured with the conventional method in glaucoma and nonglaucoma. The disc VD was also significantly lower in glaucoma than in nonglaucoma. The disc VD and mean deviation were significantly and positively correlated in both methods (conventional: R2=0.27, EDI: R2=0.22).Conclusion: The correlation between disc VD and glaucoma severity was comparable between conventional and EDI measurements. Images obtained with EDI-OCTA have the additional benefit of revealing more vascular signals in deeper layers. The disc VD, as determined by both conventional and EDI-OCTA methods, may be an indicator of glaucoma severity. Keywords: optical coherence tomography angiography, enhanced-depth imaging, vessel density, glaucoma severity, mean deviationYoshikawa YShoji TKanno JKimura IHangai MShinoda KDove Medical Pressarticleoptical coherence tomography angiographyenhanced depth imagingvessel densityglaucoma severitymean deviationOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 1113-1119 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	optical coherence tomography angiography enhanced depth imaging vessel density glaucoma severity mean deviation Ophthalmology RE1-994
spellingShingle	optical coherence tomography angiography enhanced depth imaging vessel density glaucoma severity mean deviation Ophthalmology RE1-994 Yoshikawa Y Shoji T Kanno J Kimura I Hangai M Shinoda K Optic disc vessel density in nonglaucomatous and glaucomatous eyes: an enhanced-depth imaging optical coherence tomography angiography study
description	Yuji Yoshikawa,1 Takuhei Shoji,1 Junji Kanno,1 Itaru Kimura,1 Masanori Hangai,2 Kei Shinoda1 1Department of Ophthalmology, Saitama Medical University, Saitama, Japan; 2Hangai Eye Institute, Saitama, Japan Purpose: To evaluate the ability of enhanced-depth imaging (EDI) optical coherence tomography angiography (OCTA) to detect vascular signals inside the glaucomatous optic disc.Patients and methods: Ten glaucomatous eyes of 8 subjects and 11 nonglaucomatous eyes of 7 subjects underwent EDI and conventional OCTA for optic disc analysis. The optic disc vessel density (VD) at maximum scan depth (2 mm) was compared between the 2 methods and between glaucomatous and nonglaucomatous eyes. Regression analysis was used to determine the factors affecting disc VD.Results: The median (25th, 75th percentile) of the visual field mean deviation was –20.5 (–25.1, –13.5) dB in glaucoma. The disc VD measured with the EDI method was significantly greater than that measured with the conventional method in glaucoma and nonglaucoma. The disc VD was also significantly lower in glaucoma than in nonglaucoma. The disc VD and mean deviation were significantly and positively correlated in both methods (conventional: R2=0.27, EDI: R2=0.22).Conclusion: The correlation between disc VD and glaucoma severity was comparable between conventional and EDI measurements. Images obtained with EDI-OCTA have the additional benefit of revealing more vascular signals in deeper layers. The disc VD, as determined by both conventional and EDI-OCTA methods, may be an indicator of glaucoma severity. Keywords: optical coherence tomography angiography, enhanced-depth imaging, vessel density, glaucoma severity, mean deviation
format	article
author	Yoshikawa Y Shoji T Kanno J Kimura I Hangai M Shinoda K
author_facet	Yoshikawa Y Shoji T Kanno J Kimura I Hangai M Shinoda K
author_sort	Yoshikawa Y
title	Optic disc vessel density in nonglaucomatous and glaucomatous eyes: an enhanced-depth imaging optical coherence tomography angiography study
title_short	Optic disc vessel density in nonglaucomatous and glaucomatous eyes: an enhanced-depth imaging optical coherence tomography angiography study
title_full	Optic disc vessel density in nonglaucomatous and glaucomatous eyes: an enhanced-depth imaging optical coherence tomography angiography study
title_fullStr	Optic disc vessel density in nonglaucomatous and glaucomatous eyes: an enhanced-depth imaging optical coherence tomography angiography study
title_full_unstemmed	Optic disc vessel density in nonglaucomatous and glaucomatous eyes: an enhanced-depth imaging optical coherence tomography angiography study
title_sort	optic disc vessel density in nonglaucomatous and glaucomatous eyes: an enhanced-depth imaging optical coherence tomography angiography study
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/df7e24d130df45eab8e9da43a6b546e1
work_keys_str_mv	AT yoshikaway opticdiscvesseldensityinnonglaucomatousandglaucomatouseyesanenhanceddepthimagingopticalcoherencetomographyangiographystudy AT shojit opticdiscvesseldensityinnonglaucomatousandglaucomatouseyesanenhanceddepthimagingopticalcoherencetomographyangiographystudy AT kannoj opticdiscvesseldensityinnonglaucomatousandglaucomatouseyesanenhanceddepthimagingopticalcoherencetomographyangiographystudy AT kimurai opticdiscvesseldensityinnonglaucomatousandglaucomatouseyesanenhanceddepthimagingopticalcoherencetomographyangiographystudy AT hangaim opticdiscvesseldensityinnonglaucomatousandglaucomatouseyesanenhanceddepthimagingopticalcoherencetomographyangiographystudy AT shinodak opticdiscvesseldensityinnonglaucomatousandglaucomatouseyesanenhanceddepthimagingopticalcoherencetomographyangiographystudy
_version_	1718401617324146688

Optic disc vessel density in nonglaucomatous and glaucomatous eyes: an enhanced-depth imaging optical coherence tomography angiography study

Ejemplares similares