Blink perturbation effects on saccades evoked by microstimulation of the superior colliculus.

Current knowledge of saccade-blink interactions suggests that blinks have paradoxical effects on saccade generation. Blinks suppress saccade generation by attenuating the oculomotor drive command in structures like the superior colliculus (SC), but they also disinhibit the saccadic system by removin...

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Autores principales:	Husam A Katnani, A J Van Opstal, Neeraj J Gandhi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/df8054f8da3445b8ab65b2a514eb3218
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spelling	oai:doaj.org-article:df8054f8da3445b8ab65b2a514eb32182021-11-18T08:05:06ZBlink perturbation effects on saccades evoked by microstimulation of the superior colliculus.1932-620310.1371/journal.pone.0051843https://doaj.org/article/df8054f8da3445b8ab65b2a514eb32182012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23251639/?tool=EBIhttps://doaj.org/toc/1932-6203Current knowledge of saccade-blink interactions suggests that blinks have paradoxical effects on saccade generation. Blinks suppress saccade generation by attenuating the oculomotor drive command in structures like the superior colliculus (SC), but they also disinhibit the saccadic system by removing the potent inhibition of pontine omnipause neurons (OPNs). To better characterize these effects, we evoked the trigeminal blink reflex by delivering an air puff to one eye as saccades were evoked by sub-optimal stimulation of the SC. For every stimulation site, the peak and average velocities of stimulation with blink movements (SwBMs) were lower than stimulation-only saccades (SoMs), supporting the notion that the oculomotor drive is weakened in the presence of a blink. In contrast, the duration of the SwBMs was longer, consistent with the hypothesis that the blink-induced inhibition of the OPNs could prolong the window of time available for oculomotor commands to drive an eye movement. The amplitude of the SwBM could also be larger than the SoM amplitude obtained from the same site, particularly for cases in which blink-associated eye movements exhibited the slowest kinematics. The results are interpreted in terms of neural signatures of saccade-blink interactions.Husam A KatnaniA J Van OpstalNeeraj J GandhiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e51843 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Husam A Katnani A J Van Opstal Neeraj J Gandhi Blink perturbation effects on saccades evoked by microstimulation of the superior colliculus.
description	Current knowledge of saccade-blink interactions suggests that blinks have paradoxical effects on saccade generation. Blinks suppress saccade generation by attenuating the oculomotor drive command in structures like the superior colliculus (SC), but they also disinhibit the saccadic system by removing the potent inhibition of pontine omnipause neurons (OPNs). To better characterize these effects, we evoked the trigeminal blink reflex by delivering an air puff to one eye as saccades were evoked by sub-optimal stimulation of the SC. For every stimulation site, the peak and average velocities of stimulation with blink movements (SwBMs) were lower than stimulation-only saccades (SoMs), supporting the notion that the oculomotor drive is weakened in the presence of a blink. In contrast, the duration of the SwBMs was longer, consistent with the hypothesis that the blink-induced inhibition of the OPNs could prolong the window of time available for oculomotor commands to drive an eye movement. The amplitude of the SwBM could also be larger than the SoM amplitude obtained from the same site, particularly for cases in which blink-associated eye movements exhibited the slowest kinematics. The results are interpreted in terms of neural signatures of saccade-blink interactions.
format	article
author	Husam A Katnani A J Van Opstal Neeraj J Gandhi
author_facet	Husam A Katnani A J Van Opstal Neeraj J Gandhi
author_sort	Husam A Katnani
title	Blink perturbation effects on saccades evoked by microstimulation of the superior colliculus.
title_short	Blink perturbation effects on saccades evoked by microstimulation of the superior colliculus.
title_full	Blink perturbation effects on saccades evoked by microstimulation of the superior colliculus.
title_fullStr	Blink perturbation effects on saccades evoked by microstimulation of the superior colliculus.
title_full_unstemmed	Blink perturbation effects on saccades evoked by microstimulation of the superior colliculus.
title_sort	blink perturbation effects on saccades evoked by microstimulation of the superior colliculus.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/df8054f8da3445b8ab65b2a514eb3218
work_keys_str_mv	AT husamakatnani blinkperturbationeffectsonsaccadesevokedbymicrostimulationofthesuperiorcolliculus AT ajvanopstal blinkperturbationeffectsonsaccadesevokedbymicrostimulationofthesuperiorcolliculus AT neerajjgandhi blinkperturbationeffectsonsaccadesevokedbymicrostimulationofthesuperiorcolliculus
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Blink perturbation effects on saccades evoked by microstimulation of the superior colliculus.

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