Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity
Heterogeneity within tumors presents a challenge to cancer treatment. Here, the authors investigate transcriptional heterogeneity in prostate cancer, examining expression profiles of different tissue components and highlighting expression gradients in the tumor microenvironment.
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Nature Portfolio
2018
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oai:doaj.org-article:df809a2fbbdf48cfa7dfe5406664fb322021-12-02T17:32:47ZSpatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity10.1038/s41467-018-04724-52041-1723https://doaj.org/article/df809a2fbbdf48cfa7dfe5406664fb322018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04724-5https://doaj.org/toc/2041-1723Heterogeneity within tumors presents a challenge to cancer treatment. Here, the authors investigate transcriptional heterogeneity in prostate cancer, examining expression profiles of different tissue components and highlighting expression gradients in the tumor microenvironment.Emelie BerglundJonas MaaskolaNiklas SchultzStefanie FriedrichMaja MarklundJoseph BergenstråhleFiras TarishAnna TanoglidiSanja VickovicLudvig LarssonFredrik SalménChristoph OgrisKarolina WallenborgJens LagergrenPatrik StåhlErik SonnhammerThomas HelledayJoakim LundebergNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Emelie Berglund Jonas Maaskola Niklas Schultz Stefanie Friedrich Maja Marklund Joseph Bergenstråhle Firas Tarish Anna Tanoglidi Sanja Vickovic Ludvig Larsson Fredrik Salmén Christoph Ogris Karolina Wallenborg Jens Lagergren Patrik Ståhl Erik Sonnhammer Thomas Helleday Joakim Lundeberg Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity |
| description |
Heterogeneity within tumors presents a challenge to cancer treatment. Here, the authors investigate transcriptional heterogeneity in prostate cancer, examining expression profiles of different tissue components and highlighting expression gradients in the tumor microenvironment. |
| format |
article |
| author |
Emelie Berglund Jonas Maaskola Niklas Schultz Stefanie Friedrich Maja Marklund Joseph Bergenstråhle Firas Tarish Anna Tanoglidi Sanja Vickovic Ludvig Larsson Fredrik Salmén Christoph Ogris Karolina Wallenborg Jens Lagergren Patrik Ståhl Erik Sonnhammer Thomas Helleday Joakim Lundeberg |
| author_facet |
Emelie Berglund Jonas Maaskola Niklas Schultz Stefanie Friedrich Maja Marklund Joseph Bergenstråhle Firas Tarish Anna Tanoglidi Sanja Vickovic Ludvig Larsson Fredrik Salmén Christoph Ogris Karolina Wallenborg Jens Lagergren Patrik Ståhl Erik Sonnhammer Thomas Helleday Joakim Lundeberg |
| author_sort |
Emelie Berglund |
| title |
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity |
| title_short |
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity |
| title_full |
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity |
| title_fullStr |
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity |
| title_full_unstemmed |
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity |
| title_sort |
spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/df809a2fbbdf48cfa7dfe5406664fb32 |
| work_keys_str_mv |
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1718380217440927744 |