Clear Cell Carcinoma of the Endometrium: Evaluation of Prognostic Parameters in 27 Cases

ObjectiveClear cell carcinoma (CCC) of the endometrium is an uncommon yet aggressive tumor. Few cohort studies are reporting the overall survival time of CCC patients. This study aimed to retrospectively analyze the clinicopathologic features, molecular characteristics and survival data of 27 endome...

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Autores principales:	Zhiyang Zhang, Penglian Gao, Zhengqi Bao, Linggong Zeng, Junyi Yao, Damin Chai, Tian Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	clear cell endometrial carcinoma clinicopathology prognosis overall survival clinical study Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/df809e27c1b2460aae70a5bbc69b1b88
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spelling	oai:doaj.org-article:df809e27c1b2460aae70a5bbc69b1b882021-12-02T08:49:16ZClear Cell Carcinoma of the Endometrium: Evaluation of Prognostic Parameters in 27 Cases2234-943X10.3389/fonc.2021.732782https://doaj.org/article/df809e27c1b2460aae70a5bbc69b1b882021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.732782/fullhttps://doaj.org/toc/2234-943XObjectiveClear cell carcinoma (CCC) of the endometrium is an uncommon yet aggressive tumor. Few cohort studies are reporting the overall survival time of CCC patients. This study aimed to retrospectively analyze the clinicopathologic features, molecular characteristics and survival data of 27 endometrial CCC patients to improve the understanding of CCC.MethodsThe clinicopathologic features, molecular characteristics and survival data total of 27 CCC patients admitted to the BBMU affiliated hospital (Anhui, China) between January 2005 and December 2018 were retrospectively analyzed. Kaplan-Meier method was used to analyze the prognosis-related factors.ResultsThe median age of the patients was 60 years (range; 39 to 81 years). The average tumor size was 3.8 cm (range; 0.8 to 13.0cm). Myometrial infiltration greater than 50% was reported in 55.6% of the patients, while the Ki-67 index greater than 50% was reported in 70.4% of the patients. The patients’ FIGO (2009) surgical stages were as follows: 18 I, 3 II, 4 III, and 2 IV. Besides, 7 (25.6%) patients had lymphovascular invasion, 3 (11.1%) patients with distant metastasis, including 1 patient with bone metastasis, and 2 with liver metastasis. Adjuvant treatment included 7 with chemotherapy alone, 9 with radiotherapy alone, and 9 with both radiotherapy and chemotherapy. The median overall survival time from the time of CCC diagnosis was 56 months. ER and PR showed negative expression and P16 showed patchy immunostaining. 18 (63%) cases showed Napsin A positive expression. Loss of MSH2, MSH6 and PTEN were seen in 5, 4 and 7 cases respectively. All cases showed HER-2/nue negative expression.ConclusionCCC is a rare and invasive tumor. Age of diagnosis, FIGO stage, tumor size, myometrial infiltration, lymphovascular invasion, distant metastasis, Ki-67 index and P53 expression are important indicators to evaluate patient’s prognosis (P = 0.048, P < 0.001, P = 0.016, P = 0.043, P = 0.001, P < 0.001, P = 0.026, and P = 0.007, respectively). CCC has a worse prognosis than endometrioid carcinoma (P = 0.002), and there is no significant difference when compared with uterine papillary serous carcinoma (P = 0.155).Zhiyang ZhangPenglian GaoZhengqi BaoLinggong ZengJunyi YaoDamin ChaiTian LiFrontiers Media S.A.articleclear cell endometrial carcinomaclinicopathologyprognosisoverall survivalclinical studyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	clear cell endometrial carcinoma clinicopathology prognosis overall survival clinical study Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	clear cell endometrial carcinoma clinicopathology prognosis overall survival clinical study Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Zhiyang Zhang Penglian Gao Zhengqi Bao Linggong Zeng Junyi Yao Damin Chai Tian Li Clear Cell Carcinoma of the Endometrium: Evaluation of Prognostic Parameters in 27 Cases
description	ObjectiveClear cell carcinoma (CCC) of the endometrium is an uncommon yet aggressive tumor. Few cohort studies are reporting the overall survival time of CCC patients. This study aimed to retrospectively analyze the clinicopathologic features, molecular characteristics and survival data of 27 endometrial CCC patients to improve the understanding of CCC.MethodsThe clinicopathologic features, molecular characteristics and survival data total of 27 CCC patients admitted to the BBMU affiliated hospital (Anhui, China) between January 2005 and December 2018 were retrospectively analyzed. Kaplan-Meier method was used to analyze the prognosis-related factors.ResultsThe median age of the patients was 60 years (range; 39 to 81 years). The average tumor size was 3.8 cm (range; 0.8 to 13.0cm). Myometrial infiltration greater than 50% was reported in 55.6% of the patients, while the Ki-67 index greater than 50% was reported in 70.4% of the patients. The patients’ FIGO (2009) surgical stages were as follows: 18 I, 3 II, 4 III, and 2 IV. Besides, 7 (25.6%) patients had lymphovascular invasion, 3 (11.1%) patients with distant metastasis, including 1 patient with bone metastasis, and 2 with liver metastasis. Adjuvant treatment included 7 with chemotherapy alone, 9 with radiotherapy alone, and 9 with both radiotherapy and chemotherapy. The median overall survival time from the time of CCC diagnosis was 56 months. ER and PR showed negative expression and P16 showed patchy immunostaining. 18 (63%) cases showed Napsin A positive expression. Loss of MSH2, MSH6 and PTEN were seen in 5, 4 and 7 cases respectively. All cases showed HER-2/nue negative expression.ConclusionCCC is a rare and invasive tumor. Age of diagnosis, FIGO stage, tumor size, myometrial infiltration, lymphovascular invasion, distant metastasis, Ki-67 index and P53 expression are important indicators to evaluate patient’s prognosis (P = 0.048, P < 0.001, P = 0.016, P = 0.043, P = 0.001, P < 0.001, P = 0.026, and P = 0.007, respectively). CCC has a worse prognosis than endometrioid carcinoma (P = 0.002), and there is no significant difference when compared with uterine papillary serous carcinoma (P = 0.155).
format	article
author	Zhiyang Zhang Penglian Gao Zhengqi Bao Linggong Zeng Junyi Yao Damin Chai Tian Li
author_facet	Zhiyang Zhang Penglian Gao Zhengqi Bao Linggong Zeng Junyi Yao Damin Chai Tian Li
author_sort	Zhiyang Zhang
title	Clear Cell Carcinoma of the Endometrium: Evaluation of Prognostic Parameters in 27 Cases
title_short	Clear Cell Carcinoma of the Endometrium: Evaluation of Prognostic Parameters in 27 Cases
title_full	Clear Cell Carcinoma of the Endometrium: Evaluation of Prognostic Parameters in 27 Cases
title_fullStr	Clear Cell Carcinoma of the Endometrium: Evaluation of Prognostic Parameters in 27 Cases
title_full_unstemmed	Clear Cell Carcinoma of the Endometrium: Evaluation of Prognostic Parameters in 27 Cases
title_sort	clear cell carcinoma of the endometrium: evaluation of prognostic parameters in 27 cases
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/df809e27c1b2460aae70a5bbc69b1b88
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Clear Cell Carcinoma of the Endometrium: Evaluation of Prognostic Parameters in 27 Cases

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