Type 1 Diabetes and Bone Fragility: Links and Risks

Jakob Starup-Linde,1–3 Katrine Hygum,1 Torben Harsløf,1 Bente Langdahl1 1Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark; 2Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark; 3Department of Medicine, Region Ho...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Starup-Linde J, Hygum K, Harsløf T, Langdahl B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	type 1 diabetes osteoporosis fracture falls bone mineral density Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/df8315dc300642ddb2a8ba413bf80aa1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:df8315dc300642ddb2a8ba413bf80aa1
record_format	dspace
spelling	oai:doaj.org-article:df8315dc300642ddb2a8ba413bf80aa12021-12-02T06:52:48ZType 1 Diabetes and Bone Fragility: Links and Risks1178-7007https://doaj.org/article/df8315dc300642ddb2a8ba413bf80aa12019-12-01T00:00:00Zhttps://www.dovepress.com/type-1-diabetes-and-bone-fragility-links-and-risks-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Jakob Starup-Linde,1–3 Katrine Hygum,1 Torben Harsløf,1 Bente Langdahl1 1Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark; 2Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark; 3Department of Medicine, Region Hospital Horsens, Aarhus, DenmarkCorrespondence: Jakob Starup-LindeDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, Palle Juul Jensens Boulevard 99, Aarhus N DK-8200, DenmarkTel +45 29926952Email Jakob.Linde@auh.rm.dkAbstract: Type 1 diabetes (T1D) is associated with an increased fracture risk, which is present at young and old age. Reductions in bone mineral density do not explain the increased fracture risk. Novel scanning modalities suggest that structural deficits may contribute to the increased fracture risk. Furthermore, T1D may due to insulinopenia be a state of low bone turnover. However, diabetes complications and comorbidities may influence fracture risk. Patients with T1D are fearful of falls. The diabetes related complications, hypoglycemic events, and antihypertensive treatment may all lead to falls. Thus, the increased fracture risk in T1D seems to be multifactorial, and earlier intervention with antiosteoporotic medication and focus on fall prevention is needed. This systematic review addresses the epidemiology of fractures and osteoporosis in patients with T1D and the factors that influence fracture risk.Keywords: type 1 diabetes, osteoporosis, fracture, falls, bone mineral density  Starup-Linde JHygum KHarsløf TLangdahl BDove Medical Pressarticletype 1 diabetesosteoporosisfracturefallsbone mineral densitySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 2539-2547 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	type 1 diabetes osteoporosis fracture falls bone mineral density Specialties of internal medicine RC581-951
spellingShingle	type 1 diabetes osteoporosis fracture falls bone mineral density Specialties of internal medicine RC581-951 Starup-Linde J Hygum K Harsløf T Langdahl B Type 1 Diabetes and Bone Fragility: Links and Risks
description	Jakob Starup-Linde,1–3 Katrine Hygum,1 Torben Harsløf,1 Bente Langdahl1 1Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark; 2Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark; 3Department of Medicine, Region Hospital Horsens, Aarhus, DenmarkCorrespondence: Jakob Starup-LindeDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, Palle Juul Jensens Boulevard 99, Aarhus N DK-8200, DenmarkTel +45 29926952Email Jakob.Linde@auh.rm.dkAbstract: Type 1 diabetes (T1D) is associated with an increased fracture risk, which is present at young and old age. Reductions in bone mineral density do not explain the increased fracture risk. Novel scanning modalities suggest that structural deficits may contribute to the increased fracture risk. Furthermore, T1D may due to insulinopenia be a state of low bone turnover. However, diabetes complications and comorbidities may influence fracture risk. Patients with T1D are fearful of falls. The diabetes related complications, hypoglycemic events, and antihypertensive treatment may all lead to falls. Thus, the increased fracture risk in T1D seems to be multifactorial, and earlier intervention with antiosteoporotic medication and focus on fall prevention is needed. This systematic review addresses the epidemiology of fractures and osteoporosis in patients with T1D and the factors that influence fracture risk.Keywords: type 1 diabetes, osteoporosis, fracture, falls, bone mineral density
format	article
author	Starup-Linde J Hygum K Harsløf T Langdahl B
author_facet	Starup-Linde J Hygum K Harsløf T Langdahl B
author_sort	Starup-Linde J
title	Type 1 Diabetes and Bone Fragility: Links and Risks
title_short	Type 1 Diabetes and Bone Fragility: Links and Risks
title_full	Type 1 Diabetes and Bone Fragility: Links and Risks
title_fullStr	Type 1 Diabetes and Bone Fragility: Links and Risks
title_full_unstemmed	Type 1 Diabetes and Bone Fragility: Links and Risks
title_sort	type 1 diabetes and bone fragility: links and risks
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/df8315dc300642ddb2a8ba413bf80aa1
work_keys_str_mv	AT staruplindej type1diabetesandbonefragilitylinksandrisks AT hygumk type1diabetesandbonefragilitylinksandrisks AT harsløft type1diabetesandbonefragilitylinksandrisks AT langdahlb type1diabetesandbonefragilitylinksandrisks
_version_	1718399724227133440

Type 1 Diabetes and Bone Fragility: Links and Risks

Ejemplares similares