Extracorporeal Life Support Enhances the Forward Pressure Wave to Cause a Mismatch between Cardiac Oxygen Demand and Supply

Abstract Extracorporeal life support (ECLS) is a world-famous life-saving method. Until now, changes in arterial wave properties due to ECLS have remained unexamined. In this study, we determined the effects of ECLS on arterial wave properties and ventricular/arterial coupling in male Wistar rats wi...

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Autores principales:	Chih-Hsien Wang, Ru-Wen Chang, En- Ting Wu, Yi-Jing Hsiao, Ming-Shiou Wu, Hsi-Yu Yu, Yih-Sharng Chen, Liang-Chuan Lai, Sung-Liang Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/df8605c45b18403d9e31bde0c94b5529
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spelling	oai:doaj.org-article:df8605c45b18403d9e31bde0c94b55292021-12-02T15:10:03ZExtracorporeal Life Support Enhances the Forward Pressure Wave to Cause a Mismatch between Cardiac Oxygen Demand and Supply10.1038/s41598-019-50428-12045-2322https://doaj.org/article/df8605c45b18403d9e31bde0c94b55292019-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-50428-1https://doaj.org/toc/2045-2322Abstract Extracorporeal life support (ECLS) is a world-famous life-saving method. Until now, changes in arterial wave properties due to ECLS have remained unexamined. In this study, we determined the effects of ECLS on arterial wave properties and ventricular/arterial coupling in male Wistar rats with the measured aortic pressure alone. Ascending aortic pressure signals were measured before ECLS and at 30, 60, and 90 min after weaned off. The aortic pressure signal then calculated by fourth-order derivative to obtain an assumed triangular flow wave. The ratio of mean systolic pressure to mean diastolic pressure (P ms /P md ), a parameter for evaluating the matching condition between myocardial oxygen demand and supply, was significantly higher after ECLS. The magnitude of forward pressure (\|P f \|) augmented by ECLS prevailed over the backward pressure (\|P b \|), leading to a decline in wave reflection factor. P ms /P md was positively linearly correlated with \|P f \| (P ms /P md = 0.9177 + 0.0078 × \|P f \|, r = 0.8677; P < 0.0001). These findings suggest that \|P f \| was a predominant factor responsible for the mismatch between the myocardial oxygen demand and supply in rats after ECLS phase of experiment.Chih-Hsien WangRu-Wen ChangEn- Ting WuYi-Jing HsiaoMing-Shiou WuHsi-Yu YuYih-Sharng ChenLiang-Chuan LaiSung-Liang YuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chih-Hsien Wang Ru-Wen Chang En- Ting Wu Yi-Jing Hsiao Ming-Shiou Wu Hsi-Yu Yu Yih-Sharng Chen Liang-Chuan Lai Sung-Liang Yu Extracorporeal Life Support Enhances the Forward Pressure Wave to Cause a Mismatch between Cardiac Oxygen Demand and Supply
description	Abstract Extracorporeal life support (ECLS) is a world-famous life-saving method. Until now, changes in arterial wave properties due to ECLS have remained unexamined. In this study, we determined the effects of ECLS on arterial wave properties and ventricular/arterial coupling in male Wistar rats with the measured aortic pressure alone. Ascending aortic pressure signals were measured before ECLS and at 30, 60, and 90 min after weaned off. The aortic pressure signal then calculated by fourth-order derivative to obtain an assumed triangular flow wave. The ratio of mean systolic pressure to mean diastolic pressure (P ms /P md ), a parameter for evaluating the matching condition between myocardial oxygen demand and supply, was significantly higher after ECLS. The magnitude of forward pressure (\|P f \|) augmented by ECLS prevailed over the backward pressure (\|P b \|), leading to a decline in wave reflection factor. P ms /P md was positively linearly correlated with \|P f \| (P ms /P md = 0.9177 + 0.0078 × \|P f \|, r = 0.8677; P < 0.0001). These findings suggest that \|P f \| was a predominant factor responsible for the mismatch between the myocardial oxygen demand and supply in rats after ECLS phase of experiment.
format	article
author	Chih-Hsien Wang Ru-Wen Chang En- Ting Wu Yi-Jing Hsiao Ming-Shiou Wu Hsi-Yu Yu Yih-Sharng Chen Liang-Chuan Lai Sung-Liang Yu
author_facet	Chih-Hsien Wang Ru-Wen Chang En- Ting Wu Yi-Jing Hsiao Ming-Shiou Wu Hsi-Yu Yu Yih-Sharng Chen Liang-Chuan Lai Sung-Liang Yu
author_sort	Chih-Hsien Wang
title	Extracorporeal Life Support Enhances the Forward Pressure Wave to Cause a Mismatch between Cardiac Oxygen Demand and Supply
title_short	Extracorporeal Life Support Enhances the Forward Pressure Wave to Cause a Mismatch between Cardiac Oxygen Demand and Supply
title_full	Extracorporeal Life Support Enhances the Forward Pressure Wave to Cause a Mismatch between Cardiac Oxygen Demand and Supply
title_fullStr	Extracorporeal Life Support Enhances the Forward Pressure Wave to Cause a Mismatch between Cardiac Oxygen Demand and Supply
title_full_unstemmed	Extracorporeal Life Support Enhances the Forward Pressure Wave to Cause a Mismatch between Cardiac Oxygen Demand and Supply
title_sort	extracorporeal life support enhances the forward pressure wave to cause a mismatch between cardiac oxygen demand and supply
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/df8605c45b18403d9e31bde0c94b5529
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Extracorporeal Life Support Enhances the Forward Pressure Wave to Cause a Mismatch between Cardiac Oxygen Demand and Supply

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