Towards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration

Abstract Electrolyte concentration in sweat depends on environmental context and physical condition but also on the pathophysiological status. Sweat analyzers may be therefore the future way for biological survey although how sweat electrolyte composition can reflect plasma composition remains uncle...

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Autores principales:	Donato Vairo, Laurie Bruzzese, Marion Marlinge, Lea Fuster, Nabil Adjriou, Nathalie Kipson, Philippe Brunet, Jennifer Cautela, Yves Jammes, Giovanna Mottola, Stephane Burtey, Jean Ruf, Regis Guieu, Emmanuel Fenouillet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/df8670a5d4494c62a7a1a076774c1e5d
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spelling	oai:doaj.org-article:df8670a5d4494c62a7a1a076774c1e5d2021-12-02T11:52:21ZTowards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration10.1038/s41598-017-12211-y2045-2322https://doaj.org/article/df8670a5d4494c62a7a1a076774c1e5d2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-12211-yhttps://doaj.org/toc/2045-2322Abstract Electrolyte concentration in sweat depends on environmental context and physical condition but also on the pathophysiological status. Sweat analyzers may be therefore the future way for biological survey although how sweat electrolyte composition can reflect plasma composition remains unclear. We recruited 10 healthy subjects and 6 patients to have a broad range of plasma electrolyte concentrations (chloride, potassium and sodium) and pH. These variables were compared to those found in sweat produced following cycling exercise or pilocarpine iontophoresis, a condition compatible with operating a wearable device. We found no correlation between plasma and sweat parameters when exercise-induced sweat was analyzed, and we could identify a correlation only between plasma and sweat potassium concentration (R = 0.78, p < 0.01) when sweat was induced using pilocarpine iontophoresis. We tested measurement repeatability in sweat at 24hr-interval for 3 days in 4 subjects and found a great intra-individual variability regarding all parameters in exercise-induced sweat whereas similar electrolyte levels were measured in pilocarpine-induced sweat. Thus, electrolyte concentration in sweat sampled following physical activity does not reflect concentration in plasma while pilocarpine iontophoresis appears to be promising to reproducibly address sweat electrolytes, and to make an indirect evaluation of plasma potassium concentration in chronic kidney disease and arrhythmia.Donato VairoLaurie BruzzeseMarion MarlingeLea FusterNabil AdjriouNathalie KipsonPhilippe BrunetJennifer CautelaYves JammesGiovanna MottolaStephane BurteyJean RufRegis GuieuEmmanuel FenouilletNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Donato Vairo Laurie Bruzzese Marion Marlinge Lea Fuster Nabil Adjriou Nathalie Kipson Philippe Brunet Jennifer Cautela Yves Jammes Giovanna Mottola Stephane Burtey Jean Ruf Regis Guieu Emmanuel Fenouillet Towards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration
description	Abstract Electrolyte concentration in sweat depends on environmental context and physical condition but also on the pathophysiological status. Sweat analyzers may be therefore the future way for biological survey although how sweat electrolyte composition can reflect plasma composition remains unclear. We recruited 10 healthy subjects and 6 patients to have a broad range of plasma electrolyte concentrations (chloride, potassium and sodium) and pH. These variables were compared to those found in sweat produced following cycling exercise or pilocarpine iontophoresis, a condition compatible with operating a wearable device. We found no correlation between plasma and sweat parameters when exercise-induced sweat was analyzed, and we could identify a correlation only between plasma and sweat potassium concentration (R = 0.78, p < 0.01) when sweat was induced using pilocarpine iontophoresis. We tested measurement repeatability in sweat at 24hr-interval for 3 days in 4 subjects and found a great intra-individual variability regarding all parameters in exercise-induced sweat whereas similar electrolyte levels were measured in pilocarpine-induced sweat. Thus, electrolyte concentration in sweat sampled following physical activity does not reflect concentration in plasma while pilocarpine iontophoresis appears to be promising to reproducibly address sweat electrolytes, and to make an indirect evaluation of plasma potassium concentration in chronic kidney disease and arrhythmia.
format	article
author	Donato Vairo Laurie Bruzzese Marion Marlinge Lea Fuster Nabil Adjriou Nathalie Kipson Philippe Brunet Jennifer Cautela Yves Jammes Giovanna Mottola Stephane Burtey Jean Ruf Regis Guieu Emmanuel Fenouillet
author_facet	Donato Vairo Laurie Bruzzese Marion Marlinge Lea Fuster Nabil Adjriou Nathalie Kipson Philippe Brunet Jennifer Cautela Yves Jammes Giovanna Mottola Stephane Burtey Jean Ruf Regis Guieu Emmanuel Fenouillet
author_sort	Donato Vairo
title	Towards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration
title_short	Towards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration
title_full	Towards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration
title_fullStr	Towards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration
title_full_unstemmed	Towards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration
title_sort	towards addressing the body electrolyte environment via sweat analysis:pilocarpine iontophoresis supports assessment of plasma potassium concentration
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/df8670a5d4494c62a7a1a076774c1e5d
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Towards Addressing the Body Electrolyte Environment via Sweat Analysis:Pilocarpine Iontophoresis Supports Assessment of Plasma Potassium Concentration

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