Promoting versatile vaccine development for emerging pandemics

Abstract The ongoing COVID-19 pandemic has demonstrated the importance of rapid and versatile development of emergency medical countermeasures such as vaccines. We discuss the role of platform vaccines and prototype pathogen research in modern vaccine development, and outline how previous pathogen-s...

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Autores principales:	Joshua T. Monrad, Jonas B. Sandbrink, Neil G. Cherian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/df88bc29ccc040d38772b3cc31cb2b72
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spelling	oai:doaj.org-article:df88bc29ccc040d38772b3cc31cb2b722021-12-02T14:26:47ZPromoting versatile vaccine development for emerging pandemics10.1038/s41541-021-00290-y2059-0105https://doaj.org/article/df88bc29ccc040d38772b3cc31cb2b722021-02-01T00:00:00Zhttps://doi.org/10.1038/s41541-021-00290-yhttps://doaj.org/toc/2059-0105Abstract The ongoing COVID-19 pandemic has demonstrated the importance of rapid and versatile development of emergency medical countermeasures such as vaccines. We discuss the role of platform vaccines and prototype pathogen research in modern vaccine development, and outline how previous pathogen-specific funding approaches can be improved to adequately promote vaccine R&D for emerging pandemics. We present a more comprehensive approach to financing vaccine R&D, which maximises biomedical pandemic preparedness by promoting flexible vaccine platforms and translatable research into prototype pathogens. As the numerous platform-based SARS-CoV-2 vaccines show, funders can accelerate pandemic vaccine development by proactively investing in versatile platform technologies. For certain emerging infectious diseases, where vaccine research can translate to other related pathogens with pandemic potential, investment decisions should reflect the full social value of increasing overall preparedness, rather than just the value of bringing a vaccine to market for individual pathogens.Joshua T. MonradJonas B. SandbrinkNeil G. CherianNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 6, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Joshua T. Monrad Jonas B. Sandbrink Neil G. Cherian Promoting versatile vaccine development for emerging pandemics
description	Abstract The ongoing COVID-19 pandemic has demonstrated the importance of rapid and versatile development of emergency medical countermeasures such as vaccines. We discuss the role of platform vaccines and prototype pathogen research in modern vaccine development, and outline how previous pathogen-specific funding approaches can be improved to adequately promote vaccine R&D for emerging pandemics. We present a more comprehensive approach to financing vaccine R&D, which maximises biomedical pandemic preparedness by promoting flexible vaccine platforms and translatable research into prototype pathogens. As the numerous platform-based SARS-CoV-2 vaccines show, funders can accelerate pandemic vaccine development by proactively investing in versatile platform technologies. For certain emerging infectious diseases, where vaccine research can translate to other related pathogens with pandemic potential, investment decisions should reflect the full social value of increasing overall preparedness, rather than just the value of bringing a vaccine to market for individual pathogens.
format	article
author	Joshua T. Monrad Jonas B. Sandbrink Neil G. Cherian
author_facet	Joshua T. Monrad Jonas B. Sandbrink Neil G. Cherian
author_sort	Joshua T. Monrad
title	Promoting versatile vaccine development for emerging pandemics
title_short	Promoting versatile vaccine development for emerging pandemics
title_full	Promoting versatile vaccine development for emerging pandemics
title_fullStr	Promoting versatile vaccine development for emerging pandemics
title_full_unstemmed	Promoting versatile vaccine development for emerging pandemics
title_sort	promoting versatile vaccine development for emerging pandemics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/df88bc29ccc040d38772b3cc31cb2b72
work_keys_str_mv	AT joshuatmonrad promotingversatilevaccinedevelopmentforemergingpandemics AT jonasbsandbrink promotingversatilevaccinedevelopmentforemergingpandemics AT neilgcherian promotingversatilevaccinedevelopmentforemergingpandemics
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Promoting versatile vaccine development for emerging pandemics

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