A Cu(II)–ATP complex efficiently catalyses enantioselective Diels–Alder reactions

ATP acts as a co-substrate in enzyme catalysed reactions, but can also specifically bind metal ions. Here, the authors show that ATP interacts with copper ions and forms a Cu(II)-ATP complex that efficiently catalyses Diels-Alder reactions, and determine ATP residues that are essential for this acti...

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Autores principales:	Changhao Wang, Qianqian Qi, Wenying Li, Jingshuang Dang, Min Hao, Shuting Lv, Xingchen Dong, Youkun Gu, Peizhe Wu, Wenyue Zhang, Yashao Chen, Jörg S. Hartig
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/df90ccf5e4354cb09ee5fa636f1560e9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:df90ccf5e4354cb09ee5fa636f1560e92021-12-02T17:27:20ZA Cu(II)–ATP complex efficiently catalyses enantioselective Diels–Alder reactions10.1038/s41467-020-18554-x2041-1723https://doaj.org/article/df90ccf5e4354cb09ee5fa636f1560e92020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18554-xhttps://doaj.org/toc/2041-1723ATP acts as a co-substrate in enzyme catalysed reactions, but can also specifically bind metal ions. Here, the authors show that ATP interacts with copper ions and forms a Cu(II)-ATP complex that efficiently catalyses Diels-Alder reactions, and determine ATP residues that are essential for this activity.Changhao WangQianqian QiWenying LiJingshuang DangMin HaoShuting LvXingchen DongYoukun GuPeizhe WuWenyue ZhangYashao ChenJörg S. HartigNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Changhao Wang Qianqian Qi Wenying Li Jingshuang Dang Min Hao Shuting Lv Xingchen Dong Youkun Gu Peizhe Wu Wenyue Zhang Yashao Chen Jörg S. Hartig A Cu(II)–ATP complex efficiently catalyses enantioselective Diels–Alder reactions
description	ATP acts as a co-substrate in enzyme catalysed reactions, but can also specifically bind metal ions. Here, the authors show that ATP interacts with copper ions and forms a Cu(II)-ATP complex that efficiently catalyses Diels-Alder reactions, and determine ATP residues that are essential for this activity.
format	article
author	Changhao Wang Qianqian Qi Wenying Li Jingshuang Dang Min Hao Shuting Lv Xingchen Dong Youkun Gu Peizhe Wu Wenyue Zhang Yashao Chen Jörg S. Hartig
author_facet	Changhao Wang Qianqian Qi Wenying Li Jingshuang Dang Min Hao Shuting Lv Xingchen Dong Youkun Gu Peizhe Wu Wenyue Zhang Yashao Chen Jörg S. Hartig
author_sort	Changhao Wang
title	A Cu(II)–ATP complex efficiently catalyses enantioselective Diels–Alder reactions
title_short	A Cu(II)–ATP complex efficiently catalyses enantioselective Diels–Alder reactions
title_full	A Cu(II)–ATP complex efficiently catalyses enantioselective Diels–Alder reactions
title_fullStr	A Cu(II)–ATP complex efficiently catalyses enantioselective Diels–Alder reactions
title_full_unstemmed	A Cu(II)–ATP complex efficiently catalyses enantioselective Diels–Alder reactions
title_sort	cu(ii)–atp complex efficiently catalyses enantioselective diels–alder reactions
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/df90ccf5e4354cb09ee5fa636f1560e9
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A Cu(II)–ATP complex efficiently catalyses enantioselective Diels–Alder reactions

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