Dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration

One aspect of ageing on immunity is attributed to accelerated thymic atrophy, but the underlying mechanism is still lacking. Here the authors show, using conditional reporter mouse models, that both atrophy and regeneration of the thymus are regulated by rate-limiting morphological changes in epithe...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Thomas Venables, Ann V. Griffith, Alice DeAraujo, Howard T. Petrie
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Q
Acceso en línea:https://doaj.org/article/df914271f29b44e993752f1172f879f4
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:df914271f29b44e993752f1172f879f4
record_format dspace
spelling oai:doaj.org-article:df914271f29b44e993752f1172f879f42021-12-02T15:35:56ZDynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration10.1038/s41467-019-11879-22041-1723https://doaj.org/article/df914271f29b44e993752f1172f879f42019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11879-2https://doaj.org/toc/2041-1723One aspect of ageing on immunity is attributed to accelerated thymic atrophy, but the underlying mechanism is still lacking. Here the authors show, using conditional reporter mouse models, that both atrophy and regeneration of the thymus are regulated by rate-limiting morphological changes in epithelial stroma, independent of cell death or proliferation.Thomas VenablesAnn V. GriffithAlice DeAraujoHoward T. PetrieNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Thomas Venables
Ann V. Griffith
Alice DeAraujo
Howard T. Petrie
Dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration
description One aspect of ageing on immunity is attributed to accelerated thymic atrophy, but the underlying mechanism is still lacking. Here the authors show, using conditional reporter mouse models, that both atrophy and regeneration of the thymus are regulated by rate-limiting morphological changes in epithelial stroma, independent of cell death or proliferation.
format article
author Thomas Venables
Ann V. Griffith
Alice DeAraujo
Howard T. Petrie
author_facet Thomas Venables
Ann V. Griffith
Alice DeAraujo
Howard T. Petrie
author_sort Thomas Venables
title Dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration
title_short Dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration
title_full Dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration
title_fullStr Dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration
title_full_unstemmed Dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration
title_sort dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/df914271f29b44e993752f1172f879f4
work_keys_str_mv AT thomasvenables dynamicchangesinepithelialcellmorphologycontrolthymicorgansizeduringatrophyandregeneration
AT annvgriffith dynamicchangesinepithelialcellmorphologycontrolthymicorgansizeduringatrophyandregeneration
AT alicedearaujo dynamicchangesinepithelialcellmorphologycontrolthymicorgansizeduringatrophyandregeneration
AT howardtpetrie dynamicchangesinepithelialcellmorphologycontrolthymicorgansizeduringatrophyandregeneration
_version_ 1718386444991463424