Dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration

One aspect of ageing on immunity is attributed to accelerated thymic atrophy, but the underlying mechanism is still lacking. Here the authors show, using conditional reporter mouse models, that both atrophy and regeneration of the thymus are regulated by rate-limiting morphological changes in epithe...

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Main Authors:	Thomas Venables, Ann V. Griffith, Alice DeAraujo, Howard T. Petrie
Format:	article
Language:	EN
Published:	Nature Portfolio 2019
Subjects:	Science Q
Online Access:	https://doaj.org/article/df914271f29b44e993752f1172f879f4
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spelling	oai:doaj.org-article:df914271f29b44e993752f1172f879f42021-12-02T15:35:56ZDynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration10.1038/s41467-019-11879-22041-1723https://doaj.org/article/df914271f29b44e993752f1172f879f42019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11879-2https://doaj.org/toc/2041-1723One aspect of ageing on immunity is attributed to accelerated thymic atrophy, but the underlying mechanism is still lacking. Here the authors show, using conditional reporter mouse models, that both atrophy and regeneration of the thymus are regulated by rate-limiting morphological changes in epithelial stroma, independent of cell death or proliferation.Thomas VenablesAnn V. GriffithAlice DeAraujoHoward T. PetrieNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas Venables Ann V. Griffith Alice DeAraujo Howard T. Petrie Dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration
description	One aspect of ageing on immunity is attributed to accelerated thymic atrophy, but the underlying mechanism is still lacking. Here the authors show, using conditional reporter mouse models, that both atrophy and regeneration of the thymus are regulated by rate-limiting morphological changes in epithelial stroma, independent of cell death or proliferation.
format	article
author	Thomas Venables Ann V. Griffith Alice DeAraujo Howard T. Petrie
author_facet	Thomas Venables Ann V. Griffith Alice DeAraujo Howard T. Petrie
author_sort	Thomas Venables
title	Dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration
title_short	Dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration
title_full	Dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration
title_fullStr	Dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration
title_full_unstemmed	Dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration
title_sort	dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/df914271f29b44e993752f1172f879f4
work_keys_str_mv	AT thomasvenables dynamicchangesinepithelialcellmorphologycontrolthymicorgansizeduringatrophyandregeneration AT annvgriffith dynamicchangesinepithelialcellmorphologycontrolthymicorgansizeduringatrophyandregeneration AT alicedearaujo dynamicchangesinepithelialcellmorphologycontrolthymicorgansizeduringatrophyandregeneration AT howardtpetrie dynamicchangesinepithelialcellmorphologycontrolthymicorgansizeduringatrophyandregeneration
_version_	1718386444991463424

Dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration

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