Engaging in a tone-detection task differentially modulates neural activity in the auditory cortex, amygdala, and striatum

Abstract The relationship between attention and sensory coding is an area of active investigation. Previous studies have revealed that an animal’s behavioral state can play a crucial role in shaping the characteristics of neural responses in the auditory cortex (AC). However, behavioral modulation o...

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Autores principales:	Renjia Zhong, Lanlan Ma, Ling Qin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/df91dc2ee11445598d7644e2e2337326
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spelling	oai:doaj.org-article:df91dc2ee11445598d7644e2e23373262021-12-02T15:06:26ZEngaging in a tone-detection task differentially modulates neural activity in the auditory cortex, amygdala, and striatum10.1038/s41598-017-00819-z2045-2322https://doaj.org/article/df91dc2ee11445598d7644e2e23373262017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00819-zhttps://doaj.org/toc/2045-2322Abstract The relationship between attention and sensory coding is an area of active investigation. Previous studies have revealed that an animal’s behavioral state can play a crucial role in shaping the characteristics of neural responses in the auditory cortex (AC). However, behavioral modulation of auditory response in brain areas outside the AC is not well studied. In this study, we used the same experimental paradigm to examine the effects of attention on neural activity in multiple brain regions including the primary auditory cortex (A1), posterior auditory field (PAF), amygdala (AMY), and striatum (STR). Single-unit spike activity was recorded while cats were actively performing a tone-detection task or passively listening to the same tones. We found that tone-evoked neural responses in A1 were not significantly affected by task-engagement; however, those in PAF and AMY were enhanced, and those in STR were suppressed. The enhanced effect was associated with an improvement of accuracy of tone detection, which was estimated from the spike activity. Additionally, the firing rates of A1 and PAF neurons decreased upon motor response (licking) during the detection task. Our results suggest that attention may have different effects on auditory responsive brain areas depending on their physiological functions.Renjia ZhongLanlan MaLing QinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Renjia Zhong Lanlan Ma Ling Qin Engaging in a tone-detection task differentially modulates neural activity in the auditory cortex, amygdala, and striatum
description	Abstract The relationship between attention and sensory coding is an area of active investigation. Previous studies have revealed that an animal’s behavioral state can play a crucial role in shaping the characteristics of neural responses in the auditory cortex (AC). However, behavioral modulation of auditory response in brain areas outside the AC is not well studied. In this study, we used the same experimental paradigm to examine the effects of attention on neural activity in multiple brain regions including the primary auditory cortex (A1), posterior auditory field (PAF), amygdala (AMY), and striatum (STR). Single-unit spike activity was recorded while cats were actively performing a tone-detection task or passively listening to the same tones. We found that tone-evoked neural responses in A1 were not significantly affected by task-engagement; however, those in PAF and AMY were enhanced, and those in STR were suppressed. The enhanced effect was associated with an improvement of accuracy of tone detection, which was estimated from the spike activity. Additionally, the firing rates of A1 and PAF neurons decreased upon motor response (licking) during the detection task. Our results suggest that attention may have different effects on auditory responsive brain areas depending on their physiological functions.
format	article
author	Renjia Zhong Lanlan Ma Ling Qin
author_facet	Renjia Zhong Lanlan Ma Ling Qin
author_sort	Renjia Zhong
title	Engaging in a tone-detection task differentially modulates neural activity in the auditory cortex, amygdala, and striatum
title_short	Engaging in a tone-detection task differentially modulates neural activity in the auditory cortex, amygdala, and striatum
title_full	Engaging in a tone-detection task differentially modulates neural activity in the auditory cortex, amygdala, and striatum
title_fullStr	Engaging in a tone-detection task differentially modulates neural activity in the auditory cortex, amygdala, and striatum
title_full_unstemmed	Engaging in a tone-detection task differentially modulates neural activity in the auditory cortex, amygdala, and striatum
title_sort	engaging in a tone-detection task differentially modulates neural activity in the auditory cortex, amygdala, and striatum
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/df91dc2ee11445598d7644e2e2337326
work_keys_str_mv	AT renjiazhong engaginginatonedetectiontaskdifferentiallymodulatesneuralactivityintheauditorycortexamygdalaandstriatum AT lanlanma engaginginatonedetectiontaskdifferentiallymodulatesneuralactivityintheauditorycortexamygdalaandstriatum AT lingqin engaginginatonedetectiontaskdifferentiallymodulatesneuralactivityintheauditorycortexamygdalaandstriatum
_version_	1718388483655991296

Engaging in a tone-detection task differentially modulates neural activity in the auditory cortex, amygdala, and striatum

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