Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming

Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming

The mechanisms that restore endothelial barrier integrity following inflammation-induced breaching are incompletely understood. Here the authors show that the CD31 immune receptor contributes to reestablishing vascular integrity via its effects on endothelial cell metabolism.

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Detalles Bibliográficos
Autores principales: Kenneth C. P. Cheung, Silvia Fanti, Claudio Mauro, Guosu Wang, Anitha S. Nair, Hongmei Fu, Silvia Angeletti, Silvia Spoto, Marta Fogolari, Francesco Romano, Dunja Aksentijevic, Weiwei Liu, Baiying Li, Lixin Cheng, Liwen Jiang, Juho Vuononvirta, Thanushiyan R. Poobalasingam, David M. Smith, Massimo Ciccozzi, Egle Solito, Federica M. Marelli-Berg
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/df928ac93a0a4597a8951f70e8733d1b
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Descripción
Sumario:The mechanisms that restore endothelial barrier integrity following inflammation-induced breaching are incompletely understood. Here the authors show that the CD31 immune receptor contributes to reestablishing vascular integrity via its effects on endothelial cell metabolism.

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