Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming

The mechanisms that restore endothelial barrier integrity following inflammation-induced breaching are incompletely understood. Here the authors show that the CD31 immune receptor contributes to reestablishing vascular integrity via its effects on endothelial cell metabolism.

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Autores principales: Kenneth C. P. Cheung, Silvia Fanti, Claudio Mauro, Guosu Wang, Anitha S. Nair, Hongmei Fu, Silvia Angeletti, Silvia Spoto, Marta Fogolari, Francesco Romano, Dunja Aksentijevic, Weiwei Liu, Baiying Li, Lixin Cheng, Liwen Jiang, Juho Vuononvirta, Thanushiyan R. Poobalasingam, David M. Smith, Massimo Ciccozzi, Egle Solito, Federica M. Marelli-Berg
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/df928ac93a0a4597a8951f70e8733d1b
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spelling oai:doaj.org-article:df928ac93a0a4597a8951f70e8733d1b2021-12-02T18:37:05ZPreservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming10.1038/s41467-020-17329-82041-1723https://doaj.org/article/df928ac93a0a4597a8951f70e8733d1b2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17329-8https://doaj.org/toc/2041-1723The mechanisms that restore endothelial barrier integrity following inflammation-induced breaching are incompletely understood. Here the authors show that the CD31 immune receptor contributes to reestablishing vascular integrity via its effects on endothelial cell metabolism.Kenneth C. P. CheungSilvia FantiClaudio MauroGuosu WangAnitha S. NairHongmei FuSilvia AngelettiSilvia SpotoMarta FogolariFrancesco RomanoDunja AksentijevicWeiwei LiuBaiying LiLixin ChengLiwen JiangJuho VuononvirtaThanushiyan R. PoobalasingamDavid M. SmithMassimo CiccozziEgle SolitoFederica M. Marelli-BergNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kenneth C. P. Cheung
Silvia Fanti
Claudio Mauro
Guosu Wang
Anitha S. Nair
Hongmei Fu
Silvia Angeletti
Silvia Spoto
Marta Fogolari
Francesco Romano
Dunja Aksentijevic
Weiwei Liu
Baiying Li
Lixin Cheng
Liwen Jiang
Juho Vuononvirta
Thanushiyan R. Poobalasingam
David M. Smith
Massimo Ciccozzi
Egle Solito
Federica M. Marelli-Berg
Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming
description The mechanisms that restore endothelial barrier integrity following inflammation-induced breaching are incompletely understood. Here the authors show that the CD31 immune receptor contributes to reestablishing vascular integrity via its effects on endothelial cell metabolism.
format article
author Kenneth C. P. Cheung
Silvia Fanti
Claudio Mauro
Guosu Wang
Anitha S. Nair
Hongmei Fu
Silvia Angeletti
Silvia Spoto
Marta Fogolari
Francesco Romano
Dunja Aksentijevic
Weiwei Liu
Baiying Li
Lixin Cheng
Liwen Jiang
Juho Vuononvirta
Thanushiyan R. Poobalasingam
David M. Smith
Massimo Ciccozzi
Egle Solito
Federica M. Marelli-Berg
author_facet Kenneth C. P. Cheung
Silvia Fanti
Claudio Mauro
Guosu Wang
Anitha S. Nair
Hongmei Fu
Silvia Angeletti
Silvia Spoto
Marta Fogolari
Francesco Romano
Dunja Aksentijevic
Weiwei Liu
Baiying Li
Lixin Cheng
Liwen Jiang
Juho Vuononvirta
Thanushiyan R. Poobalasingam
David M. Smith
Massimo Ciccozzi
Egle Solito
Federica M. Marelli-Berg
author_sort Kenneth C. P. Cheung
title Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming
title_short Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming
title_full Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming
title_fullStr Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming
title_full_unstemmed Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming
title_sort preservation of microvascular barrier function requires cd31 receptor-induced metabolic reprogramming
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/df928ac93a0a4597a8951f70e8733d1b
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