The Role and Mechanism of Oxidative Stress and Nuclear Receptors in the Development of NAFLD

The overproduction of reactive oxygen species (ROS) and consequent oxidative stress contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged that nonalcoholic fatty liver disease (NAFLD) is characterized as a redox-centered disease due to the role of ROS in hepatic...

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Autores principales:	Ting Hong, Yiyan Chen, Xiaoying Li, Yan Lu
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/df9515ee860a47d6b5c778188ff2c66e
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spelling	oai:doaj.org-article:df9515ee860a47d6b5c778188ff2c66e2021-11-08T02:36:05ZThe Role and Mechanism of Oxidative Stress and Nuclear Receptors in the Development of NAFLD1942-099410.1155/2021/6889533https://doaj.org/article/df9515ee860a47d6b5c778188ff2c66e2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/6889533https://doaj.org/toc/1942-0994The overproduction of reactive oxygen species (ROS) and consequent oxidative stress contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged that nonalcoholic fatty liver disease (NAFLD) is characterized as a redox-centered disease due to the role of ROS in hepatic metabolism. However, the underlying mechanisms accounting for these alternations are not completely understood. Several nuclear receptors (NRs) are dysregulated in NAFLD, and have a direct influence on the expression of a set of genes relating to the progress of hepatic lipid homeostasis and ROS generation. Meanwhile, the NRs act as redox sensors in response to metabolic stress. Therefore, targeting NRs may represent a promising strategy for improving oxidation damage and treating NAFLD. This review summarizes the link between impaired lipid metabolism and oxidative stress and highlights some NRs involved in regulating oxidant/antioxidant turnover in the context of NAFLD, shedding light on potential therapies based on NR-mediated modulation of ROS generation and lipid accumulation.Ting HongYiyan ChenXiaoying LiYan LuHindawi LimitedarticleCytologyQH573-671ENOxidative Medicine and Cellular Longevity, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Ting Hong Yiyan Chen Xiaoying Li Yan Lu The Role and Mechanism of Oxidative Stress and Nuclear Receptors in the Development of NAFLD
description	The overproduction of reactive oxygen species (ROS) and consequent oxidative stress contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged that nonalcoholic fatty liver disease (NAFLD) is characterized as a redox-centered disease due to the role of ROS in hepatic metabolism. However, the underlying mechanisms accounting for these alternations are not completely understood. Several nuclear receptors (NRs) are dysregulated in NAFLD, and have a direct influence on the expression of a set of genes relating to the progress of hepatic lipid homeostasis and ROS generation. Meanwhile, the NRs act as redox sensors in response to metabolic stress. Therefore, targeting NRs may represent a promising strategy for improving oxidation damage and treating NAFLD. This review summarizes the link between impaired lipid metabolism and oxidative stress and highlights some NRs involved in regulating oxidant/antioxidant turnover in the context of NAFLD, shedding light on potential therapies based on NR-mediated modulation of ROS generation and lipid accumulation.
format	article
author	Ting Hong Yiyan Chen Xiaoying Li Yan Lu
author_facet	Ting Hong Yiyan Chen Xiaoying Li Yan Lu
author_sort	Ting Hong
title	The Role and Mechanism of Oxidative Stress and Nuclear Receptors in the Development of NAFLD
title_short	The Role and Mechanism of Oxidative Stress and Nuclear Receptors in the Development of NAFLD
title_full	The Role and Mechanism of Oxidative Stress and Nuclear Receptors in the Development of NAFLD
title_fullStr	The Role and Mechanism of Oxidative Stress and Nuclear Receptors in the Development of NAFLD
title_full_unstemmed	The Role and Mechanism of Oxidative Stress and Nuclear Receptors in the Development of NAFLD
title_sort	role and mechanism of oxidative stress and nuclear receptors in the development of nafld
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/df9515ee860a47d6b5c778188ff2c66e
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The Role and Mechanism of Oxidative Stress and Nuclear Receptors in the Development of NAFLD

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