Sudden Infant Death Due to Postvaccinal Myocarditis: A Case Report

Background: Vaccination is a fundamental strategy in public health for controlling and eradicating infectious diseases. However, the undesirable Adverse Events Following Immunization (AEFI) should be effectively monitored, prevented, and managed in societies. Previously, Sudden Infant Death (SID) ha...

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Autores principales:	Babak Salahshour, Sajjad Sadeghi, Ahmad Sajadianfar, Kambiz Soltaninejad
Formato:	article
Lenguaje:	EN
Publicado:	Shaheed Beheshti University of Medical Sciences 2021
Materias:	vaccine death myocarditis histopathology case report Medicine (General) R5-920 Toxicology. Poisons RA1190-1270
Acceso en línea:	https://doi.org/10.32598/ijmtfm.v11i3.32227 https://doaj.org/article/df954abc15a04b80b833666b90c7072e
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spelling	oai:doaj.org-article:df954abc15a04b80b833666b90c7072e2021-11-08T12:03:16ZSudden Infant Death Due to Postvaccinal Myocarditis: A Case Reporthttps://doi.org/10.32598/ijmtfm.v11i3.322272251-87622251-8770https://doaj.org/article/df954abc15a04b80b833666b90c7072e2021-08-01T00:00:00Zhttps://journals.sbmu.ac.ir/ijmtfm/article/view/32227https://doaj.org/toc/2251-8762https://doaj.org/toc/2251-8770Background: Vaccination is a fundamental strategy in public health for controlling and eradicating infectious diseases. However, the undesirable Adverse Events Following Immunization (AEFI) should be effectively monitored, prevented, and managed in societies. Previously, Sudden Infant Death (SID) has been reported as a serious AEFI. We present a rare case of SID in an 18-month-old girl due to severe myocarditis following vaccination. Case Presentation: An 18-month-old girl presented to the Emergency Department (ED) with a history of the injection of Diphtheria-Tetanus-Whole Cell Pertussis (DTwP); Measles, Mumps, and Rubella (MMR), and oral poliovirus vaccines. She expired one-hour post ED admission after the episodes of vomiting and cardiopulmonary arrest. Postmortem histopathological examination signified marked congestion and the destruction of muscle fibers in the myocardium with inflammatory cells infiltration predominantly eosinophils. Given the postmortem histopathological findings, the cause of death was concluded as severe myocarditis following vaccination. Finally, the causality assessment was performed according to the Naranjo scale; the relevant data revealed a probable association in this regard (Naranjo score 6). Conclusion: Myocarditis is a rare and probable AEFI; thus, cardiac monitoring should be recommended as a diagnostic measure in managing postvaccinal adverse effects.Babak SalahshourSajjad SadeghiAhmad SajadianfarKambiz SoltaninejadShaheed Beheshti University of Medical Sciencesarticlevaccinedeathmyocarditishistopathologycase reportMedicine (General)R5-920Toxicology. PoisonsRA1190-1270ENInternational Journal of Medical Toxicology and Forensic Medicine, Vol 11, Iss 3, p 32227 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vaccine death myocarditis histopathology case report Medicine (General) R5-920 Toxicology. Poisons RA1190-1270
spellingShingle	vaccine death myocarditis histopathology case report Medicine (General) R5-920 Toxicology. Poisons RA1190-1270 Babak Salahshour Sajjad Sadeghi Ahmad Sajadianfar Kambiz Soltaninejad Sudden Infant Death Due to Postvaccinal Myocarditis: A Case Report
description	Background: Vaccination is a fundamental strategy in public health for controlling and eradicating infectious diseases. However, the undesirable Adverse Events Following Immunization (AEFI) should be effectively monitored, prevented, and managed in societies. Previously, Sudden Infant Death (SID) has been reported as a serious AEFI. We present a rare case of SID in an 18-month-old girl due to severe myocarditis following vaccination. Case Presentation: An 18-month-old girl presented to the Emergency Department (ED) with a history of the injection of Diphtheria-Tetanus-Whole Cell Pertussis (DTwP); Measles, Mumps, and Rubella (MMR), and oral poliovirus vaccines. She expired one-hour post ED admission after the episodes of vomiting and cardiopulmonary arrest. Postmortem histopathological examination signified marked congestion and the destruction of muscle fibers in the myocardium with inflammatory cells infiltration predominantly eosinophils. Given the postmortem histopathological findings, the cause of death was concluded as severe myocarditis following vaccination. Finally, the causality assessment was performed according to the Naranjo scale; the relevant data revealed a probable association in this regard (Naranjo score 6). Conclusion: Myocarditis is a rare and probable AEFI; thus, cardiac monitoring should be recommended as a diagnostic measure in managing postvaccinal adverse effects.
format	article
author	Babak Salahshour Sajjad Sadeghi Ahmad Sajadianfar Kambiz Soltaninejad
author_facet	Babak Salahshour Sajjad Sadeghi Ahmad Sajadianfar Kambiz Soltaninejad
author_sort	Babak Salahshour
title	Sudden Infant Death Due to Postvaccinal Myocarditis: A Case Report
title_short	Sudden Infant Death Due to Postvaccinal Myocarditis: A Case Report
title_full	Sudden Infant Death Due to Postvaccinal Myocarditis: A Case Report
title_fullStr	Sudden Infant Death Due to Postvaccinal Myocarditis: A Case Report
title_full_unstemmed	Sudden Infant Death Due to Postvaccinal Myocarditis: A Case Report
title_sort	sudden infant death due to postvaccinal myocarditis: a case report
publisher	Shaheed Beheshti University of Medical Sciences
publishDate	2021
url	https://doi.org/10.32598/ijmtfm.v11i3.32227 https://doaj.org/article/df954abc15a04b80b833666b90c7072e
work_keys_str_mv	AT babaksalahshour suddeninfantdeathduetopostvaccinalmyocarditisacasereport AT sajjadsadeghi suddeninfantdeathduetopostvaccinalmyocarditisacasereport AT ahmadsajadianfar suddeninfantdeathduetopostvaccinalmyocarditisacasereport AT kambizsoltaninejad suddeninfantdeathduetopostvaccinalmyocarditisacasereport
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Sudden Infant Death Due to Postvaccinal Myocarditis: A Case Report

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