Early Ophthalmic Changes in Macula Does Not Correlate with Visual Function

Divya Narayanan,1 Garrick Wallstrom,2 John Rodriguez,1 Donna Welch,1 Matthew Chapin,1 Paul Arrigg,3,4 Rajkumar Patil,1 Mark Abelson1,4,5 1Ora, Inc, Andover, MA, USA; 2Statistics and Data Corporation, Tempe, AZ, USA; 3Joslin Diabetes Center, Boston, MA, USA; 4Ophthalmology, Harvard Medical School, Bo...

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Autores principales:	Narayanan D, Wallstrom G, Rodriguez J, Welch D, Chapin M, Arrigg P, Patil R, Abelson M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	macula visual function amd Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/df969b0080f244d7a543fcf7382c4f18
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spelling	oai:doaj.org-article:df969b0080f244d7a543fcf7382c4f182021-12-02T10:14:20ZEarly Ophthalmic Changes in Macula Does Not Correlate with Visual Function1177-5483https://doaj.org/article/df969b0080f244d7a543fcf7382c4f182020-09-01T00:00:00Zhttps://www.dovepress.com/early-ophthalmic-changes-in-macula-does-not-correlate-with-visual-func-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Divya Narayanan,1 Garrick Wallstrom,2 John Rodriguez,1 Donna Welch,1 Matthew Chapin,1 Paul Arrigg,3,4 Rajkumar Patil,1 Mark Abelson1,4,5 1Ora, Inc, Andover, MA, USA; 2Statistics and Data Corporation, Tempe, AZ, USA; 3Joslin Diabetes Center, Boston, MA, USA; 4Ophthalmology, Harvard Medical School, Boston, MA, USA; 5Ophthalmology, Massachusetts Eye and Ear, Boston, MA, USACorrespondence: Divya NarayananOra, Inc., 300 Brickstone Square, Andover, MA 01810, USATel +1 978-685-8900Fax +1 978-689-0020Email dnarayanan@oraclinical.comPurpose: Early detection and treatment of age-related macular degeneration require a clear understanding of the early progress of the disease. The purpose of this study was to investigate whether minimal macular ophthalmoscopic changes corresponded to changes in visual function.Methods: Color macular photos from a group of older subjects who were classified as grade 0 on AREDS simplified grading were further evaluated by a retinal specialist using 5x magnification for possible minimal macular anomalies. Group 0-A (N = 15) were defined as subjects with no visible macular anomalies while Group 0-B (N = 19) comprised subjects for whom minimal macular mottling, pigment changes or very small drusen (< 63 μm) were observed in the study eye. All subjects had best VA of 20/25 or better and had no evidence of other retinal diseases in the study eye. All subjects underwent a series of visual function tests such as standard ETDRS VA, low luminance ETDRS VA, Pelli-Robson contrast sensitivity, variable contrast flicker (VCF) sensitivity, and reading speed (words per minute, wpm) using both MNRead and low luminance reading on a tablet.Results: There was no significant difference between the mean age between the two groups (74.8 ± 5.2 years for 0-A vs 74.5 ± 4.4 for 0-B, p = 0.82). None of the visual function tests identified any significant difference between the two groups. Mean ETDRS VA was 0.0 ± 0.11 for 0-A subjects and 0.08 ± 0.12 for 0-B (p = 0.063). Mean Pelli-Robson log contrast sensitivity was 1.75 ± 0.29 for 0-A and 1.78 ± 0.17 for the 0-B group (p = 0.73). VCF threshold was 0.47 ± 0.25 for 0-A and 0.43 ± 0.22 for 0-B (p = 0.64). Reading speed using MNRead was 214 ± 47.4 wpm for 0-A and 210 ± 64.7 for 0-B (p = 0.85). Low luminance tablet reading speed was 137 ± 71.8 wpm for 0-A and 151 ± 39.4 (0-B) (p = 0.49).Conclusion: A panel of psychophysical tests did not demonstrate significant differences between subjects with and without minimal macular changes.Keywords: macula, visual function, AMDNarayanan DWallstrom GRodriguez JWelch DChapin MArrigg PPatil RAbelson MDove Medical Pressarticlemaculavisual functionamdOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 2571-2576 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	macula visual function amd Ophthalmology RE1-994
spellingShingle	macula visual function amd Ophthalmology RE1-994 Narayanan D Wallstrom G Rodriguez J Welch D Chapin M Arrigg P Patil R Abelson M Early Ophthalmic Changes in Macula Does Not Correlate with Visual Function
description	Divya Narayanan,1 Garrick Wallstrom,2 John Rodriguez,1 Donna Welch,1 Matthew Chapin,1 Paul Arrigg,3,4 Rajkumar Patil,1 Mark Abelson1,4,5 1Ora, Inc, Andover, MA, USA; 2Statistics and Data Corporation, Tempe, AZ, USA; 3Joslin Diabetes Center, Boston, MA, USA; 4Ophthalmology, Harvard Medical School, Boston, MA, USA; 5Ophthalmology, Massachusetts Eye and Ear, Boston, MA, USACorrespondence: Divya NarayananOra, Inc., 300 Brickstone Square, Andover, MA 01810, USATel +1 978-685-8900Fax +1 978-689-0020Email dnarayanan@oraclinical.comPurpose: Early detection and treatment of age-related macular degeneration require a clear understanding of the early progress of the disease. The purpose of this study was to investigate whether minimal macular ophthalmoscopic changes corresponded to changes in visual function.Methods: Color macular photos from a group of older subjects who were classified as grade 0 on AREDS simplified grading were further evaluated by a retinal specialist using 5x magnification for possible minimal macular anomalies. Group 0-A (N = 15) were defined as subjects with no visible macular anomalies while Group 0-B (N = 19) comprised subjects for whom minimal macular mottling, pigment changes or very small drusen (< 63 μm) were observed in the study eye. All subjects had best VA of 20/25 or better and had no evidence of other retinal diseases in the study eye. All subjects underwent a series of visual function tests such as standard ETDRS VA, low luminance ETDRS VA, Pelli-Robson contrast sensitivity, variable contrast flicker (VCF) sensitivity, and reading speed (words per minute, wpm) using both MNRead and low luminance reading on a tablet.Results: There was no significant difference between the mean age between the two groups (74.8 ± 5.2 years for 0-A vs 74.5 ± 4.4 for 0-B, p = 0.82). None of the visual function tests identified any significant difference between the two groups. Mean ETDRS VA was 0.0 ± 0.11 for 0-A subjects and 0.08 ± 0.12 for 0-B (p = 0.063). Mean Pelli-Robson log contrast sensitivity was 1.75 ± 0.29 for 0-A and 1.78 ± 0.17 for the 0-B group (p = 0.73). VCF threshold was 0.47 ± 0.25 for 0-A and 0.43 ± 0.22 for 0-B (p = 0.64). Reading speed using MNRead was 214 ± 47.4 wpm for 0-A and 210 ± 64.7 for 0-B (p = 0.85). Low luminance tablet reading speed was 137 ± 71.8 wpm for 0-A and 151 ± 39.4 (0-B) (p = 0.49).Conclusion: A panel of psychophysical tests did not demonstrate significant differences between subjects with and without minimal macular changes.Keywords: macula, visual function, AMD
format	article
author	Narayanan D Wallstrom G Rodriguez J Welch D Chapin M Arrigg P Patil R Abelson M
author_facet	Narayanan D Wallstrom G Rodriguez J Welch D Chapin M Arrigg P Patil R Abelson M
author_sort	Narayanan D
title	Early Ophthalmic Changes in Macula Does Not Correlate with Visual Function
title_short	Early Ophthalmic Changes in Macula Does Not Correlate with Visual Function
title_full	Early Ophthalmic Changes in Macula Does Not Correlate with Visual Function
title_fullStr	Early Ophthalmic Changes in Macula Does Not Correlate with Visual Function
title_full_unstemmed	Early Ophthalmic Changes in Macula Does Not Correlate with Visual Function
title_sort	early ophthalmic changes in macula does not correlate with visual function
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/df969b0080f244d7a543fcf7382c4f18
work_keys_str_mv	AT narayanand earlyophthalmicchangesinmaculadoesnotcorrelatewithvisualfunction AT wallstromg earlyophthalmicchangesinmaculadoesnotcorrelatewithvisualfunction AT rodriguezj earlyophthalmicchangesinmaculadoesnotcorrelatewithvisualfunction AT welchd earlyophthalmicchangesinmaculadoesnotcorrelatewithvisualfunction AT chapinm earlyophthalmicchangesinmaculadoesnotcorrelatewithvisualfunction AT arriggp earlyophthalmicchangesinmaculadoesnotcorrelatewithvisualfunction AT patilr earlyophthalmicchangesinmaculadoesnotcorrelatewithvisualfunction AT abelsonm earlyophthalmicchangesinmaculadoesnotcorrelatewithvisualfunction
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Early Ophthalmic Changes in Macula Does Not Correlate with Visual Function

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