Lost opportunities for mismatch repair (MMR) screening among minority women with endometrial cancer

Abstract Lynch Syndrome (LS) prevalence in underrepresented minorities are lacking. The objective of this study was to assess the prevalence of LS in a minority patient population. Secondary objectives included identifying factors associated with successful LS screening and to characterize clinicopa...

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Autores principales:	Marilyn Huang, Tegan Hunter, Lydia A. Fein, Johnny Galli, Sophia George, Matthew Schlumbrecht, Kelly McCarter, Abdulrahman K. Sinno, Luiz P. Guido, Andre Pinto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/df98792444ad43febbe22fbdae5500e4
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spelling	oai:doaj.org-article:df98792444ad43febbe22fbdae5500e42021-12-02T18:24:55ZLost opportunities for mismatch repair (MMR) screening among minority women with endometrial cancer10.1038/s41598-021-91053-12045-2322https://doaj.org/article/df98792444ad43febbe22fbdae5500e42021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91053-1https://doaj.org/toc/2045-2322Abstract Lynch Syndrome (LS) prevalence in underrepresented minorities are lacking. The objective of this study was to assess the prevalence of LS in a minority patient population. Secondary objectives included identifying factors associated with successful LS screening and to characterize clinicopathologic features. Women with endometrial cancer treated within a university system from 2014 and 2016 were included. Immunohistochemistry (IHC) results of MLH1, PMS2, MSH2 and MSH6 were obtained from medical records and clinicopathologic factors abstracted. Patients not previously screened for LS were screened. 276 patients were evaluable. More minority women were screened as part of their routine cancer care (p = 0.005). Additionally, women 50 years or younger were more likely to be screened for LS compared to women older than 51(p = 0.009) and uninsured or reliant on Medicaid patients (p = 0.011) were more likely to be screened during routine care. Six patients received confirmatory germline testing for LS (4.3%), and another 8 patients had a staining pattern suggestive of LS. In an underrepresented population, the rate of LS in endometrial cancer is similar to previous reports. LS may be under diagnosed and opportunities missed when universal screening is not applied in minority women.Marilyn HuangTegan HunterLydia A. FeinJohnny GalliSophia GeorgeMatthew SchlumbrechtKelly McCarterAbdulrahman K. SinnoLuiz P. GuidoAndre PintoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marilyn Huang Tegan Hunter Lydia A. Fein Johnny Galli Sophia George Matthew Schlumbrecht Kelly McCarter Abdulrahman K. Sinno Luiz P. Guido Andre Pinto Lost opportunities for mismatch repair (MMR) screening among minority women with endometrial cancer
description	Abstract Lynch Syndrome (LS) prevalence in underrepresented minorities are lacking. The objective of this study was to assess the prevalence of LS in a minority patient population. Secondary objectives included identifying factors associated with successful LS screening and to characterize clinicopathologic features. Women with endometrial cancer treated within a university system from 2014 and 2016 were included. Immunohistochemistry (IHC) results of MLH1, PMS2, MSH2 and MSH6 were obtained from medical records and clinicopathologic factors abstracted. Patients not previously screened for LS were screened. 276 patients were evaluable. More minority women were screened as part of their routine cancer care (p = 0.005). Additionally, women 50 years or younger were more likely to be screened for LS compared to women older than 51(p = 0.009) and uninsured or reliant on Medicaid patients (p = 0.011) were more likely to be screened during routine care. Six patients received confirmatory germline testing for LS (4.3%), and another 8 patients had a staining pattern suggestive of LS. In an underrepresented population, the rate of LS in endometrial cancer is similar to previous reports. LS may be under diagnosed and opportunities missed when universal screening is not applied in minority women.
format	article
author	Marilyn Huang Tegan Hunter Lydia A. Fein Johnny Galli Sophia George Matthew Schlumbrecht Kelly McCarter Abdulrahman K. Sinno Luiz P. Guido Andre Pinto
author_facet	Marilyn Huang Tegan Hunter Lydia A. Fein Johnny Galli Sophia George Matthew Schlumbrecht Kelly McCarter Abdulrahman K. Sinno Luiz P. Guido Andre Pinto
author_sort	Marilyn Huang
title	Lost opportunities for mismatch repair (MMR) screening among minority women with endometrial cancer
title_short	Lost opportunities for mismatch repair (MMR) screening among minority women with endometrial cancer
title_full	Lost opportunities for mismatch repair (MMR) screening among minority women with endometrial cancer
title_fullStr	Lost opportunities for mismatch repair (MMR) screening among minority women with endometrial cancer
title_full_unstemmed	Lost opportunities for mismatch repair (MMR) screening among minority women with endometrial cancer
title_sort	lost opportunities for mismatch repair (mmr) screening among minority women with endometrial cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/df98792444ad43febbe22fbdae5500e4
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Lost opportunities for mismatch repair (MMR) screening among minority women with endometrial cancer

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