Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK–NF-κB signaling mediated inflammation

Metabolic diseases are associated with chronic, low-grade inflammation. Here the authors show that major vault protein (MVP) suppresses NF-κB signalling in macrophages via an IRAK1–TRAF6 axis and that loss of MVP in myeloid cells exacerbates the inflammatory response in mice fed a high fat diet.

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Autores principales:	Jingjing Ben, Bin Jiang, Dongdong Wang, Qingling Liu, Yongjing Zhang, Yu Qi, Xing Tong, Lili Chen, Xianzhong Liu, Yan Zhang, Xudong Zhu, Xiaoyu Li, Hanwen Zhang, Hui Bai, Qing Yang, Junqing Ma, Erik A. C. Wiemer, Yong Xu, Qi Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/df9e7fb64e9a474d90bab5fb250c8b3f
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spelling	oai:doaj.org-article:df9e7fb64e9a474d90bab5fb250c8b3f2021-12-02T16:57:22ZMajor vault protein suppresses obesity and atherosclerosis through inhibiting IKK–NF-κB signaling mediated inflammation10.1038/s41467-019-09588-x2041-1723https://doaj.org/article/df9e7fb64e9a474d90bab5fb250c8b3f2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09588-xhttps://doaj.org/toc/2041-1723Metabolic diseases are associated with chronic, low-grade inflammation. Here the authors show that major vault protein (MVP) suppresses NF-κB signalling in macrophages via an IRAK1–TRAF6 axis and that loss of MVP in myeloid cells exacerbates the inflammatory response in mice fed a high fat diet.Jingjing BenBin JiangDongdong WangQingling LiuYongjing ZhangYu QiXing TongLili ChenXianzhong LiuYan ZhangXudong ZhuXiaoyu LiHanwen ZhangHui BaiQing YangJunqing MaErik A. C. WiemerYong XuQi ChenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jingjing Ben Bin Jiang Dongdong Wang Qingling Liu Yongjing Zhang Yu Qi Xing Tong Lili Chen Xianzhong Liu Yan Zhang Xudong Zhu Xiaoyu Li Hanwen Zhang Hui Bai Qing Yang Junqing Ma Erik A. C. Wiemer Yong Xu Qi Chen Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK–NF-κB signaling mediated inflammation
description	Metabolic diseases are associated with chronic, low-grade inflammation. Here the authors show that major vault protein (MVP) suppresses NF-κB signalling in macrophages via an IRAK1–TRAF6 axis and that loss of MVP in myeloid cells exacerbates the inflammatory response in mice fed a high fat diet.
format	article
author	Jingjing Ben Bin Jiang Dongdong Wang Qingling Liu Yongjing Zhang Yu Qi Xing Tong Lili Chen Xianzhong Liu Yan Zhang Xudong Zhu Xiaoyu Li Hanwen Zhang Hui Bai Qing Yang Junqing Ma Erik A. C. Wiemer Yong Xu Qi Chen
author_facet	Jingjing Ben Bin Jiang Dongdong Wang Qingling Liu Yongjing Zhang Yu Qi Xing Tong Lili Chen Xianzhong Liu Yan Zhang Xudong Zhu Xiaoyu Li Hanwen Zhang Hui Bai Qing Yang Junqing Ma Erik A. C. Wiemer Yong Xu Qi Chen
author_sort	Jingjing Ben
title	Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK–NF-κB signaling mediated inflammation
title_short	Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK–NF-κB signaling mediated inflammation
title_full	Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK–NF-κB signaling mediated inflammation
title_fullStr	Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK–NF-κB signaling mediated inflammation
title_full_unstemmed	Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK–NF-κB signaling mediated inflammation
title_sort	major vault protein suppresses obesity and atherosclerosis through inhibiting ikk–nf-κb signaling mediated inflammation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/df9e7fb64e9a474d90bab5fb250c8b3f
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Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK–NF-κB signaling mediated inflammation

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