EVALUATION OF APPROPRIATE USE OF PEDIATRIC FRESH FROZEN PLASMA IN A TERTIARY CARE HOSPITAL

Objective: Fresh frozen plasma (FFP) is the primary source of coagulation factors. Indications of FFP use are very limited such as disseminated intravascular coagulation, massive bleeding, thrombotic thrombocytopenic purpura, biopsy for chronic liver disease, and reversing warfarin anticoagulation w...

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Autores principales:	Dilek GURLEK GOKCEBAY, Aslı TURGUTOGLU YILMAZ, İkbal Ok Bozkaya, Neşe Yaralı, Namık Yaşar Özbek, Beytullah Şantaflıoğlu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/df9ff6b89b3f45629862a31017c1e07b
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spelling	oai:doaj.org-article:df9ff6b89b3f45629862a31017c1e07b2021-11-10T04:33:49ZEVALUATION OF APPROPRIATE USE OF PEDIATRIC FRESH FROZEN PLASMA IN A TERTIARY CARE HOSPITAL2531-137910.1016/j.htct.2021.10.998https://doaj.org/article/df9ff6b89b3f45629862a31017c1e07b2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2531137921011457https://doaj.org/toc/2531-1379Objective: Fresh frozen plasma (FFP) is the primary source of coagulation factors. Indications of FFP use are very limited such as disseminated intravascular coagulation, massive bleeding, thrombotic thrombocytopenic purpura, biopsy for chronic liver disease, and reversing warfarin anticoagulation with severe bleeding. In clinical practice, FFPs are reported to be used inappropriately either in respect of the particular indication or excessive in adult studies. Therefore, we aimed in this study to evaluate indications of pediatric FFP usage in our tertiary care hospital Methodology: Patients aged 0-18 years, who were hospitalized in Ankara City Hospital Children's Hospital between September and December 2020, were analyzed retrospectively. Demographic information, diagnosis, FFP transfusion indication, pre-transfusion coagulation results, surgical procedure and bleeding status, and the amount of FFP administered were recorded. Statistical analysis was done with SPSS 18.0 program. Results: 1110 units of FFP were transfused to 324 patients (57% males) in 987 transfusion episodes. The mean age of the patients was 5.4±5.7 years68% of the transfusion episodes had a pre-transfusion coagulation testing. 249 (25%) of the transfusion episodes were given before or after minor or major surgery, and 226 (23%) were for plasmapheresis. The most FFP usage was in pediatric and cardiovascular surgery intensive care and hematology/oncology clinics. 69% of the FFP transfusions were appropriate. Conclusion: Misuse of FFP exposes patients to unpredictable adverse effects such as allergic reactions, infectious complications, hemolysis, fluid overload, and transfusion-induced acute lung injury (TRALI). In this study, the use of FFP in children was evaluated for the first time in our country, and it was found that the 31% of the FFP transfusions was inappropriate. Regular audit and education programs for the efficient use of FFP by hospital transfusion committees can improve transfusion practices.Dilek GURLEK GOKCEBAYAslı TURGUTOGLU YILMAZİkbal Ok BozkayaNeşe YaralıNamık Yaşar ÖzbekBeytullah ŞantaflıoğluElsevierarticleDiseases of the blood and blood-forming organsRC633-647.5ENHematology, Transfusion and Cell Therapy, Vol 43, Iss , Pp S28- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Dilek GURLEK GOKCEBAY Aslı TURGUTOGLU YILMAZ İkbal Ok Bozkaya Neşe Yaralı Namık Yaşar Özbek Beytullah Şantaflıoğlu EVALUATION OF APPROPRIATE USE OF PEDIATRIC FRESH FROZEN PLASMA IN A TERTIARY CARE HOSPITAL
description	Objective: Fresh frozen plasma (FFP) is the primary source of coagulation factors. Indications of FFP use are very limited such as disseminated intravascular coagulation, massive bleeding, thrombotic thrombocytopenic purpura, biopsy for chronic liver disease, and reversing warfarin anticoagulation with severe bleeding. In clinical practice, FFPs are reported to be used inappropriately either in respect of the particular indication or excessive in adult studies. Therefore, we aimed in this study to evaluate indications of pediatric FFP usage in our tertiary care hospital Methodology: Patients aged 0-18 years, who were hospitalized in Ankara City Hospital Children's Hospital between September and December 2020, were analyzed retrospectively. Demographic information, diagnosis, FFP transfusion indication, pre-transfusion coagulation results, surgical procedure and bleeding status, and the amount of FFP administered were recorded. Statistical analysis was done with SPSS 18.0 program. Results: 1110 units of FFP were transfused to 324 patients (57% males) in 987 transfusion episodes. The mean age of the patients was 5.4±5.7 years68% of the transfusion episodes had a pre-transfusion coagulation testing. 249 (25%) of the transfusion episodes were given before or after minor or major surgery, and 226 (23%) were for plasmapheresis. The most FFP usage was in pediatric and cardiovascular surgery intensive care and hematology/oncology clinics. 69% of the FFP transfusions were appropriate. Conclusion: Misuse of FFP exposes patients to unpredictable adverse effects such as allergic reactions, infectious complications, hemolysis, fluid overload, and transfusion-induced acute lung injury (TRALI). In this study, the use of FFP in children was evaluated for the first time in our country, and it was found that the 31% of the FFP transfusions was inappropriate. Regular audit and education programs for the efficient use of FFP by hospital transfusion committees can improve transfusion practices.
format	article
author	Dilek GURLEK GOKCEBAY Aslı TURGUTOGLU YILMAZ İkbal Ok Bozkaya Neşe Yaralı Namık Yaşar Özbek Beytullah Şantaflıoğlu
author_facet	Dilek GURLEK GOKCEBAY Aslı TURGUTOGLU YILMAZ İkbal Ok Bozkaya Neşe Yaralı Namık Yaşar Özbek Beytullah Şantaflıoğlu
author_sort	Dilek GURLEK GOKCEBAY
title	EVALUATION OF APPROPRIATE USE OF PEDIATRIC FRESH FROZEN PLASMA IN A TERTIARY CARE HOSPITAL
title_short	EVALUATION OF APPROPRIATE USE OF PEDIATRIC FRESH FROZEN PLASMA IN A TERTIARY CARE HOSPITAL
title_full	EVALUATION OF APPROPRIATE USE OF PEDIATRIC FRESH FROZEN PLASMA IN A TERTIARY CARE HOSPITAL
title_fullStr	EVALUATION OF APPROPRIATE USE OF PEDIATRIC FRESH FROZEN PLASMA IN A TERTIARY CARE HOSPITAL
title_full_unstemmed	EVALUATION OF APPROPRIATE USE OF PEDIATRIC FRESH FROZEN PLASMA IN A TERTIARY CARE HOSPITAL
title_sort	evaluation of appropriate use of pediatric fresh frozen plasma in a tertiary care hospital
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/df9ff6b89b3f45629862a31017c1e07b
work_keys_str_mv	AT dilekgurlekgokcebay evaluationofappropriateuseofpediatricfreshfrozenplasmainatertiarycarehospital AT aslıturgutogluyilmaz evaluationofappropriateuseofpediatricfreshfrozenplasmainatertiarycarehospital AT ikbalokbozkaya evaluationofappropriateuseofpediatricfreshfrozenplasmainatertiarycarehospital AT neseyaralı evaluationofappropriateuseofpediatricfreshfrozenplasmainatertiarycarehospital AT namıkyasarozbek evaluationofappropriateuseofpediatricfreshfrozenplasmainatertiarycarehospital AT beytullahsantaflıoglu evaluationofappropriateuseofpediatricfreshfrozenplasmainatertiarycarehospital
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EVALUATION OF APPROPRIATE USE OF PEDIATRIC FRESH FROZEN PLASMA IN A TERTIARY CARE HOSPITAL

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