Determinant factors for loss to follow-up in drug-resistant tuberculosis patients: the importance of psycho-social and economic aspects

Abstract Background Drug-resistant tuberculosis (DR-TB) is the barrier for global TB elimination efforts with a lower treatment success rate. Loss to follow-up (LTFU) in DR-TB is a serious problem, causes mortality and morbidity for patients, and leads to wide spreading of DR-TB to their family and...

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Autores principales:	Soedarsono Soedarsono, Ni Made Mertaniasih, Tutik Kusmiati, Ariani Permatasari, Ni Njoman Juliasih, Cholichul Hadi, Ilham Nur Alfian
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Drug-resistant tuberculosis Loss to follow-up Psycho-social support Economic support Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/dfa0bdc5b4d14eea9e24c22c6dd43a33
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spelling	oai:doaj.org-article:dfa0bdc5b4d14eea9e24c22c6dd43a332021-11-14T12:37:19ZDeterminant factors for loss to follow-up in drug-resistant tuberculosis patients: the importance of psycho-social and economic aspects10.1186/s12890-021-01735-91471-2466https://doaj.org/article/dfa0bdc5b4d14eea9e24c22c6dd43a332021-11-01T00:00:00Zhttps://doi.org/10.1186/s12890-021-01735-9https://doaj.org/toc/1471-2466Abstract Background Drug-resistant tuberculosis (DR-TB) is the barrier for global TB elimination efforts with a lower treatment success rate. Loss to follow-up (LTFU) in DR-TB is a serious problem, causes mortality and morbidity for patients, and leads to wide spreading of DR-TB to their family and the wider community, as well as wasting health resources. Prevention and management of LTFU is crucial to reduce mortality, prevent further spread of DR-TB, and inhibit the development and transmission of more extensively drug-resistant strains of bacteria. A study about the factors associated with loss to follow-up is needed to develop appropriate strategies to prevent DR-TB patients become loss to follow-up. This study was conducted to identify the factors correlated with loss to follow-up in DR-TB patients, using questionnaires from the point of view of patients. Methods An observational study with a cross-sectional design was conducted. Study subjects were all DR-TB patients who have declared as treatment success and loss to follow-up from DR-TB treatment. A structured questionnaire was used to collect information by interviewing the subjects as respondents. Obtained data were analyzed potential factors correlated with loss to follow-up in DR-TB patients. Results A total of 280 subjects were included in this study. Sex, working status, income, and body mass index showed a significant difference between treatment success and loss to follow-up DR-TB patients with p-value of 0.013, 0.010, 0.007, and 0.006, respectively. In regression analysis, factors correlated with increased LTFU were negative attitude towards treatment (OR = 1.2; 95% CI = 1.1–1.3), limitation of social support (OR = 1.1; 95% CI = 1.0–1.2), dissatisfaction with health service (OR = 2.1; 95% CI = 1.5–3.0)), and limitation of economic status (OR = 1.1; 95% CI = 1.0–1.2)). Conclusions Male patients, jobless, non-regular employee, lower income, and underweight BMI were found in higher proportion in LTFU patients. Negative attitude towards treatment, limitation of social support, dissatisfaction with health service, and limitation of economic status are factors correlated with increased LTFU in DR-TB patients. Non-compliance to treatment is complex, we suggest that the involvement and support from the combination of health ministry, labor and employment ministry, and social ministry may help to resolve the complex problems of LTFU in DR-TB patients.Soedarsono SoedarsonoNi Made MertaniasihTutik KusmiatiAriani PermatasariNi Njoman JuliasihCholichul HadiIlham Nur AlfianBMCarticleDrug-resistant tuberculosisLoss to follow-upPsycho-social supportEconomic supportDiseases of the respiratory systemRC705-779ENBMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Drug-resistant tuberculosis Loss to follow-up Psycho-social support Economic support Diseases of the respiratory system RC705-779
spellingShingle	Drug-resistant tuberculosis Loss to follow-up Psycho-social support Economic support Diseases of the respiratory system RC705-779 Soedarsono Soedarsono Ni Made Mertaniasih Tutik Kusmiati Ariani Permatasari Ni Njoman Juliasih Cholichul Hadi Ilham Nur Alfian Determinant factors for loss to follow-up in drug-resistant tuberculosis patients: the importance of psycho-social and economic aspects
description	Abstract Background Drug-resistant tuberculosis (DR-TB) is the barrier for global TB elimination efforts with a lower treatment success rate. Loss to follow-up (LTFU) in DR-TB is a serious problem, causes mortality and morbidity for patients, and leads to wide spreading of DR-TB to their family and the wider community, as well as wasting health resources. Prevention and management of LTFU is crucial to reduce mortality, prevent further spread of DR-TB, and inhibit the development and transmission of more extensively drug-resistant strains of bacteria. A study about the factors associated with loss to follow-up is needed to develop appropriate strategies to prevent DR-TB patients become loss to follow-up. This study was conducted to identify the factors correlated with loss to follow-up in DR-TB patients, using questionnaires from the point of view of patients. Methods An observational study with a cross-sectional design was conducted. Study subjects were all DR-TB patients who have declared as treatment success and loss to follow-up from DR-TB treatment. A structured questionnaire was used to collect information by interviewing the subjects as respondents. Obtained data were analyzed potential factors correlated with loss to follow-up in DR-TB patients. Results A total of 280 subjects were included in this study. Sex, working status, income, and body mass index showed a significant difference between treatment success and loss to follow-up DR-TB patients with p-value of 0.013, 0.010, 0.007, and 0.006, respectively. In regression analysis, factors correlated with increased LTFU were negative attitude towards treatment (OR = 1.2; 95% CI = 1.1–1.3), limitation of social support (OR = 1.1; 95% CI = 1.0–1.2), dissatisfaction with health service (OR = 2.1; 95% CI = 1.5–3.0)), and limitation of economic status (OR = 1.1; 95% CI = 1.0–1.2)). Conclusions Male patients, jobless, non-regular employee, lower income, and underweight BMI were found in higher proportion in LTFU patients. Negative attitude towards treatment, limitation of social support, dissatisfaction with health service, and limitation of economic status are factors correlated with increased LTFU in DR-TB patients. Non-compliance to treatment is complex, we suggest that the involvement and support from the combination of health ministry, labor and employment ministry, and social ministry may help to resolve the complex problems of LTFU in DR-TB patients.
format	article
author	Soedarsono Soedarsono Ni Made Mertaniasih Tutik Kusmiati Ariani Permatasari Ni Njoman Juliasih Cholichul Hadi Ilham Nur Alfian
author_facet	Soedarsono Soedarsono Ni Made Mertaniasih Tutik Kusmiati Ariani Permatasari Ni Njoman Juliasih Cholichul Hadi Ilham Nur Alfian
author_sort	Soedarsono Soedarsono
title	Determinant factors for loss to follow-up in drug-resistant tuberculosis patients: the importance of psycho-social and economic aspects
title_short	Determinant factors for loss to follow-up in drug-resistant tuberculosis patients: the importance of psycho-social and economic aspects
title_full	Determinant factors for loss to follow-up in drug-resistant tuberculosis patients: the importance of psycho-social and economic aspects
title_fullStr	Determinant factors for loss to follow-up in drug-resistant tuberculosis patients: the importance of psycho-social and economic aspects
title_full_unstemmed	Determinant factors for loss to follow-up in drug-resistant tuberculosis patients: the importance of psycho-social and economic aspects
title_sort	determinant factors for loss to follow-up in drug-resistant tuberculosis patients: the importance of psycho-social and economic aspects
publisher	BMC
publishDate	2021
url	https://doaj.org/article/dfa0bdc5b4d14eea9e24c22c6dd43a33
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Determinant factors for loss to follow-up in drug-resistant tuberculosis patients: the importance of psycho-social and economic aspects

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