Natural Products from Actinomycetes Associated with Marine Organisms

The actinomycetes have proven to be a rich source of bioactive secondary metabolites and play a critical role in the development of pharmaceutical researches. With interactions of host organisms and having special ecological status, the actinomycetes associated with marine animals, marine plants, ma...

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Autores principales:	Jianing Chen, Lin Xu, Yanrong Zhou, Bingnan Han
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	actinomycetes marine animals marine plants macroalgae secondary metabolites structural diversity Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/dfa1ebf938024b1788f71e8432aa2def
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spelling	oai:doaj.org-article:dfa1ebf938024b1788f71e8432aa2def2021-11-25T18:12:56ZNatural Products from Actinomycetes Associated with Marine Organisms10.3390/md191106291660-3397https://doaj.org/article/dfa1ebf938024b1788f71e8432aa2def2021-11-01T00:00:00Zhttps://www.mdpi.com/1660-3397/19/11/629https://doaj.org/toc/1660-3397The actinomycetes have proven to be a rich source of bioactive secondary metabolites and play a critical role in the development of pharmaceutical researches. With interactions of host organisms and having special ecological status, the actinomycetes associated with marine animals, marine plants, macroalgae, cyanobacteria, and lichens have more potential to produce active metabolites acting as chemical defenses to protect the host from predators as well as microbial infection. This review focuses on 536 secondary metabolites (SMs) from actinomycetes associated with these marine organisms covering the literature to mid-2021, which will highlight the taxonomic diversity of actinomycetes and the structural classes, biological activities of SMs. Among all the actinomycetes listed, members of <i>Streptomyces</i> (68%), <i>Micromonospora</i> (6%), and <i>Nocardiopsis</i> (3%) are dominant producers of secondary metabolites. Additionally, alkaloids (37%), polyketides (33%), and peptides (15%) comprise the largest proportion of natural products with mostly antimicrobial activity and cytotoxicity. Furthermore, the data analysis and clinical information of SMs have been summarized in this article, suggesting that some of these actinomycetes with multiple host organisms deserve more attention to their special ecological status and genetic factors.Jianing ChenLin XuYanrong ZhouBingnan HanMDPI AGarticleactinomycetesmarine animalsmarine plantsmacroalgaesecondary metabolitesstructural diversityBiology (General)QH301-705.5ENMarine Drugs, Vol 19, Iss 629, p 629 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	actinomycetes marine animals marine plants macroalgae secondary metabolites structural diversity Biology (General) QH301-705.5
spellingShingle	actinomycetes marine animals marine plants macroalgae secondary metabolites structural diversity Biology (General) QH301-705.5 Jianing Chen Lin Xu Yanrong Zhou Bingnan Han Natural Products from Actinomycetes Associated with Marine Organisms
description	The actinomycetes have proven to be a rich source of bioactive secondary metabolites and play a critical role in the development of pharmaceutical researches. With interactions of host organisms and having special ecological status, the actinomycetes associated with marine animals, marine plants, macroalgae, cyanobacteria, and lichens have more potential to produce active metabolites acting as chemical defenses to protect the host from predators as well as microbial infection. This review focuses on 536 secondary metabolites (SMs) from actinomycetes associated with these marine organisms covering the literature to mid-2021, which will highlight the taxonomic diversity of actinomycetes and the structural classes, biological activities of SMs. Among all the actinomycetes listed, members of <i>Streptomyces</i> (68%), <i>Micromonospora</i> (6%), and <i>Nocardiopsis</i> (3%) are dominant producers of secondary metabolites. Additionally, alkaloids (37%), polyketides (33%), and peptides (15%) comprise the largest proportion of natural products with mostly antimicrobial activity and cytotoxicity. Furthermore, the data analysis and clinical information of SMs have been summarized in this article, suggesting that some of these actinomycetes with multiple host organisms deserve more attention to their special ecological status and genetic factors.
format	article
author	Jianing Chen Lin Xu Yanrong Zhou Bingnan Han
author_facet	Jianing Chen Lin Xu Yanrong Zhou Bingnan Han
author_sort	Jianing Chen
title	Natural Products from Actinomycetes Associated with Marine Organisms
title_short	Natural Products from Actinomycetes Associated with Marine Organisms
title_full	Natural Products from Actinomycetes Associated with Marine Organisms
title_fullStr	Natural Products from Actinomycetes Associated with Marine Organisms
title_full_unstemmed	Natural Products from Actinomycetes Associated with Marine Organisms
title_sort	natural products from actinomycetes associated with marine organisms
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/dfa1ebf938024b1788f71e8432aa2def
work_keys_str_mv	AT jianingchen naturalproductsfromactinomycetesassociatedwithmarineorganisms AT linxu naturalproductsfromactinomycetesassociatedwithmarineorganisms AT yanrongzhou naturalproductsfromactinomycetesassociatedwithmarineorganisms AT bingnanhan naturalproductsfromactinomycetesassociatedwithmarineorganisms
_version_	1718411530445258752

Natural Products from Actinomycetes Associated with Marine Organisms

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