IL-33-ST2 axis regulates myeloid cell differentiation and activation enabling effective club cell regeneration

IL-33-ST2 axis regulates myeloid cell differentiation and activation enabling effective club cell regeneration

Signaling of IL-33 via its receptor, ST2, has been implicated in macrophage function in tissue repair. Here the authors show, using genetic mouse models and single-cell transcriptomic data, that the IL-33/ST2 axis regulates both ILC2-derived IL-13 and macrophage differentiation/reparative function r...

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Autores principales: Rania Dagher, Alan M. Copenhaver, Valerie Besnard, Aaron Berlin, Fatima Hamidi, Marielle Maret, Jingya Wang, Xiaotao Qu, Yashaswi Shrestha, Jincheng Wu, Gregory Gautier, Rajiv Raja, Michel Aubier, Roland Kolbeck, Alison A. Humbles, Marina Pretolani
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/dfa2aff3dc9744c0adab9ba6f648aaa3
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Sumario:Signaling of IL-33 via its receptor, ST2, has been implicated in macrophage function in tissue repair. Here the authors show, using genetic mouse models and single-cell transcriptomic data, that the IL-33/ST2 axis regulates both ILC2-derived IL-13 and macrophage differentiation/reparative function required for club cell regeneration.

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