IL-33-ST2 axis regulates myeloid cell differentiation and activation enabling effective club cell regeneration

Signaling of IL-33 via its receptor, ST2, has been implicated in macrophage function in tissue repair. Here the authors show, using genetic mouse models and single-cell transcriptomic data, that the IL-33/ST2 axis regulates both ILC2-derived IL-13 and macrophage differentiation/reparative function r...

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Autores principales:	Rania Dagher, Alan M. Copenhaver, Valerie Besnard, Aaron Berlin, Fatima Hamidi, Marielle Maret, Jingya Wang, Xiaotao Qu, Yashaswi Shrestha, Jincheng Wu, Gregory Gautier, Rajiv Raja, Michel Aubier, Roland Kolbeck, Alison A. Humbles, Marina Pretolani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dfa2aff3dc9744c0adab9ba6f648aaa3
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spelling	oai:doaj.org-article:dfa2aff3dc9744c0adab9ba6f648aaa32021-12-02T18:48:11ZIL-33-ST2 axis regulates myeloid cell differentiation and activation enabling effective club cell regeneration10.1038/s41467-020-18466-w2041-1723https://doaj.org/article/dfa2aff3dc9744c0adab9ba6f648aaa32020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18466-whttps://doaj.org/toc/2041-1723Signaling of IL-33 via its receptor, ST2, has been implicated in macrophage function in tissue repair. Here the authors show, using genetic mouse models and single-cell transcriptomic data, that the IL-33/ST2 axis regulates both ILC2-derived IL-13 and macrophage differentiation/reparative function required for club cell regeneration.Rania DagherAlan M. CopenhaverValerie BesnardAaron BerlinFatima HamidiMarielle MaretJingya WangXiaotao QuYashaswi ShresthaJincheng WuGregory GautierRajiv RajaMichel AubierRoland KolbeckAlison A. HumblesMarina PretolaniNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rania Dagher Alan M. Copenhaver Valerie Besnard Aaron Berlin Fatima Hamidi Marielle Maret Jingya Wang Xiaotao Qu Yashaswi Shrestha Jincheng Wu Gregory Gautier Rajiv Raja Michel Aubier Roland Kolbeck Alison A. Humbles Marina Pretolani IL-33-ST2 axis regulates myeloid cell differentiation and activation enabling effective club cell regeneration
description	Signaling of IL-33 via its receptor, ST2, has been implicated in macrophage function in tissue repair. Here the authors show, using genetic mouse models and single-cell transcriptomic data, that the IL-33/ST2 axis regulates both ILC2-derived IL-13 and macrophage differentiation/reparative function required for club cell regeneration.
format	article
author	Rania Dagher Alan M. Copenhaver Valerie Besnard Aaron Berlin Fatima Hamidi Marielle Maret Jingya Wang Xiaotao Qu Yashaswi Shrestha Jincheng Wu Gregory Gautier Rajiv Raja Michel Aubier Roland Kolbeck Alison A. Humbles Marina Pretolani
author_facet	Rania Dagher Alan M. Copenhaver Valerie Besnard Aaron Berlin Fatima Hamidi Marielle Maret Jingya Wang Xiaotao Qu Yashaswi Shrestha Jincheng Wu Gregory Gautier Rajiv Raja Michel Aubier Roland Kolbeck Alison A. Humbles Marina Pretolani
author_sort	Rania Dagher
title	IL-33-ST2 axis regulates myeloid cell differentiation and activation enabling effective club cell regeneration
title_short	IL-33-ST2 axis regulates myeloid cell differentiation and activation enabling effective club cell regeneration
title_full	IL-33-ST2 axis regulates myeloid cell differentiation and activation enabling effective club cell regeneration
title_fullStr	IL-33-ST2 axis regulates myeloid cell differentiation and activation enabling effective club cell regeneration
title_full_unstemmed	IL-33-ST2 axis regulates myeloid cell differentiation and activation enabling effective club cell regeneration
title_sort	il-33-st2 axis regulates myeloid cell differentiation and activation enabling effective club cell regeneration
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/dfa2aff3dc9744c0adab9ba6f648aaa3
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IL-33-ST2 axis regulates myeloid cell differentiation and activation enabling effective club cell regeneration

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