Immunoregulatory effect of mesenchymal stem cell via mitochondria signaling pathways in allergic asthma

Asthma is a complicated lung disease, which has increased morbidity and mortality rates in worldwide. There is an overlap between asthma pathophysiology and mitochondrial dysfunction and MSCs may have regulatory effect on mitochondrial dysfunction and treats asthma. Therefore, immune-modulatory effe...

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Autores principales:	Minmin Huang, Entezar Mehrabi Nasab, Seyyed Shamsadin Athari
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	MSC Inflammation Immune system Allergy Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/dfa2b6d2d79340208aab6b63109c1122
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spelling	oai:doaj.org-article:dfa2b6d2d79340208aab6b63109c11222021-11-20T04:56:33ZImmunoregulatory effect of mesenchymal stem cell via mitochondria signaling pathways in allergic asthma1319-562X10.1016/j.sjbs.2021.07.071https://doaj.org/article/dfa2b6d2d79340208aab6b63109c11222021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1319562X21006549https://doaj.org/toc/1319-562XAsthma is a complicated lung disease, which has increased morbidity and mortality rates in worldwide. There is an overlap between asthma pathophysiology and mitochondrial dysfunction and MSCs may have regulatory effect on mitochondrial dysfunction and treats asthma. Therefore, immune-modulatory effect of MSCs and mitochondrial signaling pathways in asthma was studied.After culturing of MSCs and producing asthma animal model, the mice were treated with MSCs via IV via IT. BALf's eosinophil Counting, The levels of IL-4, −5, −13, −25, –33, INF-γ, Cys-LT, LTB4, LTC4, mitochondria genes expression of COX-1, COX-2, ND1, Nrf2, Cytb were measured and lung histopathological study were done.BALf's eosinophils, the levels of IL-4, −5, −13, −25, –33, LTB4, LTC4, Cys-LT, the mitochondria genes expression (COX-1, COX-2, Cytb and ND-1), perivascular and peribronchial inflammation, mucus hyper-production and hyperplasia of the goblet cell in pathological study were significantly decreased in MSCs-treated asthma mice and reverse trend was found about Nrf-2 gene expression, IFN-γ level and ratio of the INF-γ/IL-4.MSC therapy can control inflammation, immune-inflammatory factors in asthma and mitochondrial related genes, and prevent asthma immune-pathology.Minmin HuangEntezar Mehrabi NasabSeyyed Shamsadin AthariElsevierarticleMSCInflammationImmune systemAllergyBiology (General)QH301-705.5ENSaudi Journal of Biological Sciences, Vol 28, Iss 12, Pp 6957-6962 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	MSC Inflammation Immune system Allergy Biology (General) QH301-705.5
spellingShingle	MSC Inflammation Immune system Allergy Biology (General) QH301-705.5 Minmin Huang Entezar Mehrabi Nasab Seyyed Shamsadin Athari Immunoregulatory effect of mesenchymal stem cell via mitochondria signaling pathways in allergic asthma
description	Asthma is a complicated lung disease, which has increased morbidity and mortality rates in worldwide. There is an overlap between asthma pathophysiology and mitochondrial dysfunction and MSCs may have regulatory effect on mitochondrial dysfunction and treats asthma. Therefore, immune-modulatory effect of MSCs and mitochondrial signaling pathways in asthma was studied.After culturing of MSCs and producing asthma animal model, the mice were treated with MSCs via IV via IT. BALf's eosinophil Counting, The levels of IL-4, −5, −13, −25, –33, INF-γ, Cys-LT, LTB4, LTC4, mitochondria genes expression of COX-1, COX-2, ND1, Nrf2, Cytb were measured and lung histopathological study were done.BALf's eosinophils, the levels of IL-4, −5, −13, −25, –33, LTB4, LTC4, Cys-LT, the mitochondria genes expression (COX-1, COX-2, Cytb and ND-1), perivascular and peribronchial inflammation, mucus hyper-production and hyperplasia of the goblet cell in pathological study were significantly decreased in MSCs-treated asthma mice and reverse trend was found about Nrf-2 gene expression, IFN-γ level and ratio of the INF-γ/IL-4.MSC therapy can control inflammation, immune-inflammatory factors in asthma and mitochondrial related genes, and prevent asthma immune-pathology.
format	article
author	Minmin Huang Entezar Mehrabi Nasab Seyyed Shamsadin Athari
author_facet	Minmin Huang Entezar Mehrabi Nasab Seyyed Shamsadin Athari
author_sort	Minmin Huang
title	Immunoregulatory effect of mesenchymal stem cell via mitochondria signaling pathways in allergic asthma
title_short	Immunoregulatory effect of mesenchymal stem cell via mitochondria signaling pathways in allergic asthma
title_full	Immunoregulatory effect of mesenchymal stem cell via mitochondria signaling pathways in allergic asthma
title_fullStr	Immunoregulatory effect of mesenchymal stem cell via mitochondria signaling pathways in allergic asthma
title_full_unstemmed	Immunoregulatory effect of mesenchymal stem cell via mitochondria signaling pathways in allergic asthma
title_sort	immunoregulatory effect of mesenchymal stem cell via mitochondria signaling pathways in allergic asthma
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/dfa2b6d2d79340208aab6b63109c1122
work_keys_str_mv	AT minminhuang immunoregulatoryeffectofmesenchymalstemcellviamitochondriasignalingpathwaysinallergicasthma AT entezarmehrabinasab immunoregulatoryeffectofmesenchymalstemcellviamitochondriasignalingpathwaysinallergicasthma AT seyyedshamsadinathari immunoregulatoryeffectofmesenchymalstemcellviamitochondriasignalingpathwaysinallergicasthma
_version_	1718419746323431424

Immunoregulatory effect of mesenchymal stem cell via mitochondria signaling pathways in allergic asthma

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