Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome

Gut lumen antigens must be continuously sampled by the immune system to maintain proper immune homeostasis. Here the authors show that activated CCR6+CCR1+GL7- gut B cells retrieve lumen antigens from specialized M cells and transfer them across the subepithelial dome in the Peyer’s patch to contrib...

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Autores principales:	Rathan Joy Komban, Anneli Strömberg, Adi Biram, Jakob Cervin, Cristina Lebrero-Fernández, Neil Mabbott, Ulf Yrlid, Ziv Shulman, Mats Bemark, Nils Lycke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dfa3b986a6dc4e698df2c098d4517404
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spelling	oai:doaj.org-article:dfa3b986a6dc4e698df2c098d45174042021-12-02T17:01:57ZActivated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome10.1038/s41467-019-10144-w2041-1723https://doaj.org/article/dfa3b986a6dc4e698df2c098d45174042019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10144-whttps://doaj.org/toc/2041-1723Gut lumen antigens must be continuously sampled by the immune system to maintain proper immune homeostasis. Here the authors show that activated CCR6+CCR1+GL7- gut B cells retrieve lumen antigens from specialized M cells and transfer them across the subepithelial dome in the Peyer’s patch to contribute to the maintenance of gut humoral immunity.Rathan Joy KombanAnneli StrömbergAdi BiramJakob CervinCristina Lebrero-FernándezNeil MabbottUlf YrlidZiv ShulmanMats BemarkNils LyckeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rathan Joy Komban Anneli Strömberg Adi Biram Jakob Cervin Cristina Lebrero-Fernández Neil Mabbott Ulf Yrlid Ziv Shulman Mats Bemark Nils Lycke Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome
description	Gut lumen antigens must be continuously sampled by the immune system to maintain proper immune homeostasis. Here the authors show that activated CCR6+CCR1+GL7- gut B cells retrieve lumen antigens from specialized M cells and transfer them across the subepithelial dome in the Peyer’s patch to contribute to the maintenance of gut humoral immunity.
format	article
author	Rathan Joy Komban Anneli Strömberg Adi Biram Jakob Cervin Cristina Lebrero-Fernández Neil Mabbott Ulf Yrlid Ziv Shulman Mats Bemark Nils Lycke
author_facet	Rathan Joy Komban Anneli Strömberg Adi Biram Jakob Cervin Cristina Lebrero-Fernández Neil Mabbott Ulf Yrlid Ziv Shulman Mats Bemark Nils Lycke
author_sort	Rathan Joy Komban
title	Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome
title_short	Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome
title_full	Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome
title_fullStr	Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome
title_full_unstemmed	Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome
title_sort	activated peyer′s patch b cells sample antigen directly from m cells in the subepithelial dome
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/dfa3b986a6dc4e698df2c098d4517404
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Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome

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