Aberrant immune responses in a mouse with behavioral disorders.

BTBR T+tf/J (BTBR) mice have recently been reported to have behaviors that resemble those of autistic individuals, in that this strain has impairments in social interactions and a restricted repetitive and stereotyped pattern of behaviors. Since immune responses, including autoimmune responses, are...

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Autores principales:	Yong Heo, Yubin Zhang, Donghong Gao, Veronica M Miller, David A Lawrence
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dfa52b4514c54ba4a9521d959697aac2
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spelling	oai:doaj.org-article:dfa52b4514c54ba4a9521d959697aac22021-11-18T06:49:56ZAberrant immune responses in a mouse with behavioral disorders.1932-620310.1371/journal.pone.0020912https://doaj.org/article/dfa52b4514c54ba4a9521d959697aac22011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21799730/?tool=EBIhttps://doaj.org/toc/1932-6203BTBR T+tf/J (BTBR) mice have recently been reported to have behaviors that resemble those of autistic individuals, in that this strain has impairments in social interactions and a restricted repetitive and stereotyped pattern of behaviors. Since immune responses, including autoimmune responses, are known to affect behavior, and individuals with autism have aberrant immune activities, we evaluated the immune system of BTBR mice, and compared their immunity and degree of neuroinflammation with that of C57BL/6 (B6) mice, a highly social control strain, and with F1 offspring. Mice were assessed at postnatal day (pnd) 21 and after behavioral analysis at pnd70. BTBR mice had significantly higher amounts of serum IgG and IgE, of IgG anti-brain antibodies (Abs), and of IgG and IgE deposited in the brain, elevated expression of cytokines, especially IL-33 IL-18, and IL-1β in the brain, and an increased proportion of MHC class II-expressing microglia compared to B6 mice. The F1 mice had intermediate levels of Abs and cytokines as well as social activity. The high Ab levels of BTBR mice are in agreement with their increased numbers of CD40(hi)/I-A(hi) B cells and IgG-secreting B cells. Upon immunization with KLH, the BTBR mice produced 2-3 times more anti-KLH Abs than B6 mice. In contrast to humoral immunity, BTBR mice are significantly more susceptible to listeriosis than B6 or BALB/c mice. The Th2-like immune profile of the BTBR mice and their constitutive neuroinflammation suggests that an autoimmune profile is implicated in their aberrant behaviors, as has been suggested for some humans with autism.Yong HeoYubin ZhangDonghong GaoVeronica M MillerDavid A LawrencePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e20912 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yong Heo Yubin Zhang Donghong Gao Veronica M Miller David A Lawrence Aberrant immune responses in a mouse with behavioral disorders.
description	BTBR T+tf/J (BTBR) mice have recently been reported to have behaviors that resemble those of autistic individuals, in that this strain has impairments in social interactions and a restricted repetitive and stereotyped pattern of behaviors. Since immune responses, including autoimmune responses, are known to affect behavior, and individuals with autism have aberrant immune activities, we evaluated the immune system of BTBR mice, and compared their immunity and degree of neuroinflammation with that of C57BL/6 (B6) mice, a highly social control strain, and with F1 offspring. Mice were assessed at postnatal day (pnd) 21 and after behavioral analysis at pnd70. BTBR mice had significantly higher amounts of serum IgG and IgE, of IgG anti-brain antibodies (Abs), and of IgG and IgE deposited in the brain, elevated expression of cytokines, especially IL-33 IL-18, and IL-1β in the brain, and an increased proportion of MHC class II-expressing microglia compared to B6 mice. The F1 mice had intermediate levels of Abs and cytokines as well as social activity. The high Ab levels of BTBR mice are in agreement with their increased numbers of CD40(hi)/I-A(hi) B cells and IgG-secreting B cells. Upon immunization with KLH, the BTBR mice produced 2-3 times more anti-KLH Abs than B6 mice. In contrast to humoral immunity, BTBR mice are significantly more susceptible to listeriosis than B6 or BALB/c mice. The Th2-like immune profile of the BTBR mice and their constitutive neuroinflammation suggests that an autoimmune profile is implicated in their aberrant behaviors, as has been suggested for some humans with autism.
format	article
author	Yong Heo Yubin Zhang Donghong Gao Veronica M Miller David A Lawrence
author_facet	Yong Heo Yubin Zhang Donghong Gao Veronica M Miller David A Lawrence
author_sort	Yong Heo
title	Aberrant immune responses in a mouse with behavioral disorders.
title_short	Aberrant immune responses in a mouse with behavioral disorders.
title_full	Aberrant immune responses in a mouse with behavioral disorders.
title_fullStr	Aberrant immune responses in a mouse with behavioral disorders.
title_full_unstemmed	Aberrant immune responses in a mouse with behavioral disorders.
title_sort	aberrant immune responses in a mouse with behavioral disorders.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/dfa52b4514c54ba4a9521d959697aac2
work_keys_str_mv	AT yongheo aberrantimmuneresponsesinamousewithbehavioraldisorders AT yubinzhang aberrantimmuneresponsesinamousewithbehavioraldisorders AT donghonggao aberrantimmuneresponsesinamousewithbehavioraldisorders AT veronicammiller aberrantimmuneresponsesinamousewithbehavioraldisorders AT davidalawrence aberrantimmuneresponsesinamousewithbehavioraldisorders
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Aberrant immune responses in a mouse with behavioral disorders.

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