Effective Potential Description of the Interaction between Single Stem Cells and Localized Ligands

Cell signaling is essential for cell fate determination and tissue patterning. As signaling ligands are presented to the receiving cell, they are recruited and recognized by the cell membrane so as to elicit a biological response and to pattern multicellular tissues. Cells can accumulate and transpo...

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Autores principales:	Ignacio Bordeu, Clare Garcin, Shukry J. Habib, Gunnar Pruessner
Formato:	article
Lenguaje:	EN
Publicado:	American Physical Society 2020
Materias:	Physics QC1-999
Acceso en línea:	https://doaj.org/article/dfa7229200fc4ce7949f00f1513d524e
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spelling	oai:doaj.org-article:dfa7229200fc4ce7949f00f1513d524e2021-12-02T12:09:47ZEffective Potential Description of the Interaction between Single Stem Cells and Localized Ligands10.1103/PhysRevX.10.0410222160-3308https://doaj.org/article/dfa7229200fc4ce7949f00f1513d524e2020-10-01T00:00:00Zhttp://doi.org/10.1103/PhysRevX.10.041022http://doi.org/10.1103/PhysRevX.10.041022https://doaj.org/toc/2160-3308Cell signaling is essential for cell fate determination and tissue patterning. As signaling ligands are presented to the receiving cell, they are recruited and recognized by the cell membrane so as to elicit a biological response and to pattern multicellular tissues. Cells can accumulate and transport these ligands, which results in an emergent organization of the ligands’ spatial distribution. To study this organization, we make use of a simplified experimental setup, in which single mouse embryonic stem cells (mESCs) can interact with immobilized ligands. We introduce a two-species age-dependent correlation function that allows the description and quantification of the spatiotemporal dynamics of single cell-ligand interactions. Through the analysis of mESC data and numerical simulations, we show that cells act as effective force-field generators, perturbing and organizing their environment. This organization, captured in the form of an aging effective potential, is an emergent property of the population of single cells interacting with randomly distributed localized ligands.Ignacio BordeuClare GarcinShukry J. HabibGunnar PruessnerAmerican Physical SocietyarticlePhysicsQC1-999ENPhysical Review X, Vol 10, Iss 4, p 041022 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Physics QC1-999
spellingShingle	Physics QC1-999 Ignacio Bordeu Clare Garcin Shukry J. Habib Gunnar Pruessner Effective Potential Description of the Interaction between Single Stem Cells and Localized Ligands
description	Cell signaling is essential for cell fate determination and tissue patterning. As signaling ligands are presented to the receiving cell, they are recruited and recognized by the cell membrane so as to elicit a biological response and to pattern multicellular tissues. Cells can accumulate and transport these ligands, which results in an emergent organization of the ligands’ spatial distribution. To study this organization, we make use of a simplified experimental setup, in which single mouse embryonic stem cells (mESCs) can interact with immobilized ligands. We introduce a two-species age-dependent correlation function that allows the description and quantification of the spatiotemporal dynamics of single cell-ligand interactions. Through the analysis of mESC data and numerical simulations, we show that cells act as effective force-field generators, perturbing and organizing their environment. This organization, captured in the form of an aging effective potential, is an emergent property of the population of single cells interacting with randomly distributed localized ligands.
format	article
author	Ignacio Bordeu Clare Garcin Shukry J. Habib Gunnar Pruessner
author_facet	Ignacio Bordeu Clare Garcin Shukry J. Habib Gunnar Pruessner
author_sort	Ignacio Bordeu
title	Effective Potential Description of the Interaction between Single Stem Cells and Localized Ligands
title_short	Effective Potential Description of the Interaction between Single Stem Cells and Localized Ligands
title_full	Effective Potential Description of the Interaction between Single Stem Cells and Localized Ligands
title_fullStr	Effective Potential Description of the Interaction between Single Stem Cells and Localized Ligands
title_full_unstemmed	Effective Potential Description of the Interaction between Single Stem Cells and Localized Ligands
title_sort	effective potential description of the interaction between single stem cells and localized ligands
publisher	American Physical Society
publishDate	2020
url	https://doaj.org/article/dfa7229200fc4ce7949f00f1513d524e
work_keys_str_mv	AT ignaciobordeu effectivepotentialdescriptionoftheinteractionbetweensinglestemcellsandlocalizedligands AT claregarcin effectivepotentialdescriptionoftheinteractionbetweensinglestemcellsandlocalizedligands AT shukryjhabib effectivepotentialdescriptionoftheinteractionbetweensinglestemcellsandlocalizedligands AT gunnarpruessner effectivepotentialdescriptionoftheinteractionbetweensinglestemcellsandlocalizedligands
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Effective Potential Description of the Interaction between Single Stem Cells and Localized Ligands

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