A combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screening

On-chip synthesis and screening has been used to automate drug discovery but on-chip analysis still remains a major limitation. Here, the authors report on a dendrimer-based surface patterning method to create nanodroplet arrays on materials which allow for on-chip high-throughput analysis.

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Bibliographic Details
Main Authors: Maximilian Benz, Arndt Asperger, Meike Hamester, Alexander Welle, Stefan Heissler, Pavel A. Levkin
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Q
Online Access:https://doaj.org/article/dfad5ffb04194c0ab15d26319b74982c
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Summary:On-chip synthesis and screening has been used to automate drug discovery but on-chip analysis still remains a major limitation. Here, the authors report on a dendrimer-based surface patterning method to create nanodroplet arrays on materials which allow for on-chip high-throughput analysis.