A combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screening

On-chip synthesis and screening has been used to automate drug discovery but on-chip analysis still remains a major limitation. Here, the authors report on a dendrimer-based surface patterning method to create nanodroplet arrays on materials which allow for on-chip high-throughput analysis.

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Autores principales:	Maximilian Benz, Arndt Asperger, Meike Hamester, Alexander Welle, Stefan Heissler, Pavel A. Levkin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dfad5ffb04194c0ab15d26319b74982c
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spelling	oai:doaj.org-article:dfad5ffb04194c0ab15d26319b74982c2021-12-02T17:32:28ZA combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screening10.1038/s41467-020-19040-02041-1723https://doaj.org/article/dfad5ffb04194c0ab15d26319b74982c2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19040-0https://doaj.org/toc/2041-1723On-chip synthesis and screening has been used to automate drug discovery but on-chip analysis still remains a major limitation. Here, the authors report on a dendrimer-based surface patterning method to create nanodroplet arrays on materials which allow for on-chip high-throughput analysis.Maximilian BenzArndt AspergerMeike HamesterAlexander WelleStefan HeisslerPavel A. LevkinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maximilian Benz Arndt Asperger Meike Hamester Alexander Welle Stefan Heissler Pavel A. Levkin A combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screening
description	On-chip synthesis and screening has been used to automate drug discovery but on-chip analysis still remains a major limitation. Here, the authors report on a dendrimer-based surface patterning method to create nanodroplet arrays on materials which allow for on-chip high-throughput analysis.
format	article
author	Maximilian Benz Arndt Asperger Meike Hamester Alexander Welle Stefan Heissler Pavel A. Levkin
author_facet	Maximilian Benz Arndt Asperger Meike Hamester Alexander Welle Stefan Heissler Pavel A. Levkin
author_sort	Maximilian Benz
title	A combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screening
title_short	A combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screening
title_full	A combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screening
title_fullStr	A combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screening
title_full_unstemmed	A combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screening
title_sort	combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screening
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/dfad5ffb04194c0ab15d26319b74982c
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A combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screening

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