Molecular imaging of orthotopic prostate cancer with nanobubble ultrasound contrast agents targeted to PSMA
Abstract Ultrasound imaging is routinely used to guide prostate biopsies, yet delineation of tumors within the prostate gland is extremely challenging, even with microbubble (MB) contrast. A more effective ultrasound protocol is needed that can effectively localize malignancies for targeted biopsy o...
Guardado en:
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/dfae35f73a544e6d9446108aa0e7a7a8 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:dfae35f73a544e6d9446108aa0e7a7a8 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:dfae35f73a544e6d9446108aa0e7a7a82021-12-02T13:34:32ZMolecular imaging of orthotopic prostate cancer with nanobubble ultrasound contrast agents targeted to PSMA10.1038/s41598-021-84072-52045-2322https://doaj.org/article/dfae35f73a544e6d9446108aa0e7a7a82021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84072-5https://doaj.org/toc/2045-2322Abstract Ultrasound imaging is routinely used to guide prostate biopsies, yet delineation of tumors within the prostate gland is extremely challenging, even with microbubble (MB) contrast. A more effective ultrasound protocol is needed that can effectively localize malignancies for targeted biopsy or aid in patient selection and treatment planning for organ-sparing focal therapy. This study focused on evaluating the application of a novel nanobubble ultrasound contrast agent targeted to the prostate specific membrane antigen (PSMA-targeted NBs) in ultrasound imaging of prostate cancer (PCa) in vivo using a clinically relevant orthotopic tumor model in nude mice. Our results demonstrated that PSMA-targeted NBs had increased extravasation and retention in PSMA-expressing orthotopic mouse tumors. These processes are reflected in significantly different time intensity curve (TIC) and several kinetic parameters for targeted versus non-targeted NBs or LUMASON MBs. These, may in turn, lead to improved image-based detection and diagnosis of PCa in the future.Yu WangAl Christopher De LeonReshani PereraEric AbenojarRamamurthy GopalakrishnanJames P. BasilionXinning WangAgata A. ExnerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Yu Wang Al Christopher De Leon Reshani Perera Eric Abenojar Ramamurthy Gopalakrishnan James P. Basilion Xinning Wang Agata A. Exner Molecular imaging of orthotopic prostate cancer with nanobubble ultrasound contrast agents targeted to PSMA |
| description |
Abstract Ultrasound imaging is routinely used to guide prostate biopsies, yet delineation of tumors within the prostate gland is extremely challenging, even with microbubble (MB) contrast. A more effective ultrasound protocol is needed that can effectively localize malignancies for targeted biopsy or aid in patient selection and treatment planning for organ-sparing focal therapy. This study focused on evaluating the application of a novel nanobubble ultrasound contrast agent targeted to the prostate specific membrane antigen (PSMA-targeted NBs) in ultrasound imaging of prostate cancer (PCa) in vivo using a clinically relevant orthotopic tumor model in nude mice. Our results demonstrated that PSMA-targeted NBs had increased extravasation and retention in PSMA-expressing orthotopic mouse tumors. These processes are reflected in significantly different time intensity curve (TIC) and several kinetic parameters for targeted versus non-targeted NBs or LUMASON MBs. These, may in turn, lead to improved image-based detection and diagnosis of PCa in the future. |
| format |
article |
| author |
Yu Wang Al Christopher De Leon Reshani Perera Eric Abenojar Ramamurthy Gopalakrishnan James P. Basilion Xinning Wang Agata A. Exner |
| author_facet |
Yu Wang Al Christopher De Leon Reshani Perera Eric Abenojar Ramamurthy Gopalakrishnan James P. Basilion Xinning Wang Agata A. Exner |
| author_sort |
Yu Wang |
| title |
Molecular imaging of orthotopic prostate cancer with nanobubble ultrasound contrast agents targeted to PSMA |
| title_short |
Molecular imaging of orthotopic prostate cancer with nanobubble ultrasound contrast agents targeted to PSMA |
| title_full |
Molecular imaging of orthotopic prostate cancer with nanobubble ultrasound contrast agents targeted to PSMA |
| title_fullStr |
Molecular imaging of orthotopic prostate cancer with nanobubble ultrasound contrast agents targeted to PSMA |
| title_full_unstemmed |
Molecular imaging of orthotopic prostate cancer with nanobubble ultrasound contrast agents targeted to PSMA |
| title_sort |
molecular imaging of orthotopic prostate cancer with nanobubble ultrasound contrast agents targeted to psma |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/dfae35f73a544e6d9446108aa0e7a7a8 |
| work_keys_str_mv |
AT yuwang molecularimagingoforthotopicprostatecancerwithnanobubbleultrasoundcontrastagentstargetedtopsma AT alchristopherdeleon molecularimagingoforthotopicprostatecancerwithnanobubbleultrasoundcontrastagentstargetedtopsma AT reshaniperera molecularimagingoforthotopicprostatecancerwithnanobubbleultrasoundcontrastagentstargetedtopsma AT ericabenojar molecularimagingoforthotopicprostatecancerwithnanobubbleultrasoundcontrastagentstargetedtopsma AT ramamurthygopalakrishnan molecularimagingoforthotopicprostatecancerwithnanobubbleultrasoundcontrastagentstargetedtopsma AT jamespbasilion molecularimagingoforthotopicprostatecancerwithnanobubbleultrasoundcontrastagentstargetedtopsma AT xinningwang molecularimagingoforthotopicprostatecancerwithnanobubbleultrasoundcontrastagentstargetedtopsma AT agataaexner molecularimagingoforthotopicprostatecancerwithnanobubbleultrasoundcontrastagentstargetedtopsma |
| _version_ |
1718392826586202112 |